Abstract：
:The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques. Hemodynamic variables, blood lactate, and glucose levels were monitored throughout the 40 min NCFI occlusion period. After 48 h, rats were killed and the extent of neuronal injury was determined in the cortex, striatum, and hippocampus. Hemodynamic variables recorded during ischemia improved with clonidine treatment in both normo- and hyperglycemic groups. Glutamate and aspartate levels were greatly increased over control values during normo- and hyperglycemic NCFI treatment. Clonidine pretreatment suppressed the release of both glutamate and aspartate during NCFI in normo- and hyperglycemic rodents when compared with NCFI-treated normo- and hyperglycemic rats without the drug. Significant neuroprotection of cells in the cortex, striatum, and hippocampus was also observed in drug-treated animals 48 h postischemia. The combined effects of diminished glutamate release after NCFI and reduced neuronal injury in both normo- and hyperglycemic states suggests that clonidine treatment during NCFI is neuroprotective. The neuroprotective effect of clonidine during ischemia may be ascribed to both a sensitization of central sympathetic activity and a reduced release of glutamate thereby reducing NMDA receptor activation and neuronal damage.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Jellish WS,Murdoch J,Kindel G,Zhang X,White FAdoi
10.1007/s00221-005-0064-4keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
526-34issue
4eissn
0014-4819issn
1432-1106journal_volume
167pub_type
杂志文章abstract：OBJECTIVE:Restoration of somatosensory deficits in humans requires a clear understanding of the neural representations of percepts. To characterize the cortical response to naturalistic somatosensation, we examined field potentials in the primary somatosensory cortex of humans. METHODS:Four patients with intractable e...
journal_title：Experimental brain research
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doi：10.1007/s00221-019-05495-1
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abstract：:Little is known about mechanisms used by the nervous system to encode time. In light of recent evidence, cerebellar cortex involvement in the learned timing of conditioned eyelid responses shows promise as an area of investigation into neural timing mechanisms. Lesion studies indicate that the cerebellar cortex is nec...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
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abstract：:We investigated in sheep the effects of stimulation of the thick afferent fibers running through the lingual nerve (LN) upon the activity of some of the muscles and medullary interneurons or motoneurons which are active during swallowing. Using electromyography (EMG), and extra- and intracellular neuronal recording, w...
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doi：10.1007/s00221-012-3253-y
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abstract：:The topographical mapping of glial fibrillary acidic protein (GFAP)-immunoreactivity was performed in coronal serial sections of the rat mesencephalon, rhombencephalon and spinal cord. Relative to a background of poor or moderate overall staining of the mesencephalon, the interpeduncular nucleus, substantia nigra and ...
journal_title：Experimental brain research
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abstract：:The superior branch of the vestibular nerve containing peripheral axons of primary afferents originating in the lateral and anterior semicircular canals was cut bilaterally in three monkeys (vestibular neurectomy). Vertical and horizontal components of eye position were monitored by electro-oculography (EOG) during di...
journal_title：Experimental brain research
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abstract：:Eye and head rotations are normally correlated with changes in walking direction; however, it is unknown whether they play a causal role in the control of steering. The objective of the present study was to answer two questions about the role of head rotations in steering control when walking to a goal. First, are hea...
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pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
abstract：:Shape is an inherent property of objects existing in both vision and touch but not audition. Can shape then be represented by sound artificially? It has previously been shown that sound can convey visual information by means of image-to-sound coding, but whether sound can code tactile information is not clear. Blindfo...
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pub_type： 杂志文章
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3082-z
更新日期：2012-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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