Abstract：
:Little is known about mechanisms used by the nervous system to encode time. In light of recent evidence, cerebellar cortex involvement in the learned timing of conditioned eyelid responses shows promise as an area of investigation into neural timing mechanisms. Lesion studies indicate that the cerebellar cortex is necessary for response timing, but do not rule out the possibility that response timing is encoded afferent to the cerebellum. To differentiate between precerebellar and cerebellar cortical timing mechanisms, rabbits were trained by pairing direct stimulation of mossy fibers in the cerebellum as the conditioned stimulus (CS) with an eyeshock unconditioned stimulus (US). We find that individual animals can produce differently timed conditioned responses when trained with a mossy fiber CS that has been paired with the US at various interstimulus intervals. The fact that differently timed responses can be conditioned using constant-frequency stimulation of an invariant subset of mossy fibers as the CS suggests that timing information in the afferent input to the cerebellum is not essential. Two rabbits trained with single-pulse stimulation in the cerebellum as the CS also learned differently timed conditioned responses; suggesting that fiber recruitment during a stimulus train does not convey the necessary temporal coding to the cerebellar cortex. Together with the lesion data, these findings suggest that the learned timing of conditioned eyelid responses occurs in the cerebellar cortex.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Perrett SPdoi
10.1007/s002210050443subject
Has Abstractpub_date
1998-07-01 00:00:00pages
115-24issue
2eissn
0014-4819issn
1432-1106journal_volume
121pub_type
杂志文章,评审abstract：:Injections of tritiated tracer precursors into one eye revealed a highly variable lamination pattern of the LGN in the marmoset Callithrix. In one specimen, only four cell layers were apparent with some indication of further differentiation. In a second specimen, six almost complete relay layers were found in the occi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235574
更新日期：1978-11-15 00:00:00
abstract：:Besides luminance change, the pupil responds to changes in spatial pattern, color content and target motion. Our experimental results show that transient pupillary constriction can also be elicited by dichoptically viewing a change in stereoscopic stimuli composed of dynamic random-dot stereograms from an initially fl...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2161-1
更新日期：2005-01-01 00:00:00
abstract：:Everyday life requires the ability to flexibly switch between tasks. Often, task switching is accompanied by concurrent cognitive activities that compete for limited attentional resources. This study aimed to characterize the effects of attentional load on task switching. In experiment 1, participants performed an int...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3452-1
更新日期：2013-06-01 00:00:00
abstract：:Motor imagery (MI - i.e., the mental representation of an action without physically executing it) stimulates brain motor networks and promotes motor learning after spinal cord injury (SCI). An interesting issue is whether the brain networks controlling MI are being reorganized with reference to spared motor functions....
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4114-7
更新日期：2015-01-01 00:00:00
abstract：:The topographical mapping of glial fibrillary acidic protein (GFAP)-immunoreactivity was performed in coronal serial sections of the rat mesencephalon, rhombencephalon and spinal cord. Relative to a background of poor or moderate overall staining of the mesencephalon, the interpeduncular nucleus, substantia nigra and ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230695
更新日期：1989-01-01 00:00:00
abstract：:This study examined hippocampal theta power during configural and non-configural tasks in rats. Experiment 1 compared hippocampal theta power during a negative patterning task (A+, B+, AB-) to a configural task and a simple discrimination task (A+, B-) as a non-configural task. The results showed that hippocampal thet...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3359-2
更新日期：2013-03-01 00:00:00
abstract：:The neural activity in area 7a and the arm area of motor cortex was recorded while real or path-guided apparent motion stimuli were presented to behaving monkeys in the absence of a motor response. A smooth stimulus motion was produced in the real motion condition, whereas in the apparent motion condition five stimuli...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1664-5
更新日期：2004-02-01 00:00:00
abstract：:The relationship between neuronal calcium binding protein content (calbindin D28K: CaBP and parvalbumin: PV) and vulnerability to ischemia was studied in different regions of the rat brain using the four vessel occlusion model of complete forebrain ischemia. The areas studied, i.e. the hippocampal formation, neocortex...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00232193
更新日期：1990-01-01 00:00:00
abstract：:The gain of the vestibulo-ocular reflex (VOR) of intact pigmented rats was adaptively modified by training protocols that created a visual-vestibular conflict. For training, head restrained animals were oscillated on a turntable in front of an optokinetic pattern projected onto a cylindrical wall. The optokinetic patt...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230530
更新日期：1991-01-01 00:00:00
abstract：:Several experiments have suggested that similar physiological substrates are involved in movement execution and motor imagery, and that the same laws of movement control apply to both processes. Using a mental chronometry paradigm, we examined the effects of movement direction and added mass on the duration of actual ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1012-1
更新日期：2002-04-01 00:00:00
abstract：:The present study examined the kinematics of unrestricted reaches to prismatically-displaced targets. The kinematic analysis allowed us (1) to document how and where in the reach adjustments were made to compensate for the prismatic displacement. (2) to detail the changes that occur in the characteristics of reaches d...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230245
更新日期：1989-01-01 00:00:00
abstract：:5-Hydroxytryptamine (5-HT) has the most diverse set of receptors in comparison with any other neurotransmitter or hormone in the body. To date, seven families of 5-HT receptors have been characterized. A great number of studies have been published regarding the role of 5-HT and its receptors in seizures. However, with...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-013-3757-0
更新日期：2014-02-01 00:00:00
abstract：:The present study was designed to compare the performance of nine dyslexic boys and nine age- and IQ-matched controls on tasks which presumably tap visual functions dependent on the subcortical magnocellular (M) pathway (flicker sensitivity) and the cortical dorsal stream (stereoacuity, structure-from-motion, visuomot...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231069
更新日期：1995-01-01 00:00:00
abstract：:Regulation of food intake is very important for health. It has been reported that people have decreased appetite at high altitude (HA). The current study recruited long-term HA residents to participate in an fMRI experiment which involved food craving. Result shows that the HA group showed decreased activation in the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2516-8
更新日期：2011-04-01 00:00:00
abstract：:Previous studies have shown that the "synaptic" bodies of mammalian pinealocytes are a heterogeneous group of organelles. Whereas "synaptic" ribbons (SR) exhibit a day/night rhythm with small numbers during daytime and high numbers at night, the so-called "synaptic" spherules (SS) show species-specific differences in ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236214
更新日期：1987-01-01 00:00:00
abstract：:A wealth of evidence implicates the crossed descending projection from the superior colliculus (SC) in orientation and approach behaviours directed towards novel, non-noxious stimuli. In our preceding paper, we identified a population of nociceptive neurones in the rat SC that have axons that project to the contralate...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231781
更新日期：1996-05-01 00:00:00
abstract：:There is ample evidence that motor learning changes the function of perceptual systems. Previous studies examining the interactions between speech production and perception have shown that the discrimination of phonetic contrasts characterized by the difference in articulatory place features is altered following their...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05584-1
更新日期：2019-09-01 00:00:00
abstract：:The extent to which attending to one stimulus while ignoring another influences the integration of visual and inertial (vestibular, somatosensory, proprioceptive) stimuli is currently unknown. It is also unclear how cue integration is affected by an awareness of cue conflicts. We investigated these questions using a t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1767-8
更新日期：2009-09-01 00:00:00
abstract：:The time course of 72-kDa heat-shock protein (hsp72) induction was evaluated by immunoblotting in cerebral cortex, striatum, hippocampus, cerebellum, liver, and kidney of rats subjected to 60-min focal cerebral ischemia following proximal unilateral occlusion of the right middle cerebral artery (MCA). Neurological exa...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000564
更新日期：2001-01-01 00:00:00
abstract：:The amyloid precursor protein (APP) has a pivotal role in pathogenesis of Alzheimer's disease (AD) via its beta- and gamma-secretase-derived cleavage products--the A-beta peptides. An alternative processing pathway provided by the alpha-secretase prevents formation of those toxic peptides and gives rise to the neurotr...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-011-2885-7
更新日期：2012-04-01 00:00:00
abstract：:Dorsomedial frontal cortex (DMFC) was studied in monkeys trained to make visually guided eye or arm movements. Portions of DMFC are involved in the execution of learned, goal-directed behaviors. Many neurons discharge with both eye and hand movements as well as when motor responses are withheld, provided these behavio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247300
更新日期：1988-01-01 00:00:00
abstract：:Previous research has shown that the timing of a sensor-motor event is recalibrated after a brief exposure to a delayed feedback of a voluntary action (Stetson et al. 2006). Here, we examined whether it is the sensory or motor event that is shifted in time. We compared lag adaption for action-feedback in visuo-motor p...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2047-3
更新日期：2010-03-01 00:00:00
abstract：:Extracellular single-unit recordings were made during day- and night-time in the pineal gland of urethane-anesthetized adult male Sprague-Dawley rats. All cells exhibiting spontaneous electrical activity had firing frequencies from less than 1 Hz to about 100 Hz, and their discharge patterns were characterized as regu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235276
更新日期：1984-01-01 00:00:00
abstract：:Evidence suggests that Parkinson's disease (PD) patients produce large spatial errors when reaching to proprioceptively defined targets. Here, we examined whether these movement inaccuracies result mainly from impaired use of proprioceptive inputs for movement planning mechanisms or from on-line movement guidance. Med...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4343-4
更新日期：2015-09-01 00:00:00
abstract：:Prism adaptation (PA) is a promising rehabilitation technique for visuo-spatial neglect, an attention disorder that is characterized by spatial attention deficits (i.e., deficits in orienting). PA involves visuo-motor adaptation to rightward shifting prism goggles. Following goggle removal, this adaptation results in ...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-015-4218-8
更新日期：2015-05-01 00:00:00
abstract：:The axonal conduction latency of brisk-sustained and brisk-transient cat retinal ganglion cells increases with proximity to the area centralis. The trend is gradual with considerable local scatter of latencies, and is similar for cells with crossed and uncrossed axons. ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238731
更新日期：1975-07-11 00:00:00
abstract：:Ocular responses to optokinetic stimulation were reexamined in adult albino rats of two different strains. Eye movements were measured in head-restrained animals using the search coil method. In contrast to some previous results, the albino rats showed optokinetic nystagmus, and some of them made responses comparable ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235639
更新日期：1985-01-01 00:00:00
abstract：:The anatomical pathway from the prepyriform cortex to the hippocampus in the cat was traced autoradiographically by means of anterograde transport of [3H] leucine. A direct projection from the prepyriform cortex to the lateral entorhinal area was confirmed in the cat: the termination of these fibers was largely confin...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236644
更新日期：1980-02-01 00:00:00
abstract：:The gap effect refers to the finding that saccadic latencies are typically reduced when a fixation point is removed prior to the appearance of a peripheral target. This reduction in saccadic reaction time (SacRT) is thought to be due to a general warning effect and an oculomotor specific fixation offset that occur whe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002219900243
更新日期：2000-01-01 00:00:00
abstract：:During the flight of Spacelab-1 a series of vestibular experiments was performed on the crew by a group of European investigators. Control experiments were carried out on the same subjects pre- and postflight. The tests included caloric stimulation of the ears, threshold measurements of response to linear acceleration...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237739
更新日期：1986-01-01 00:00:00
