Abstract：
:The dual-task (motor and cognitive) performance of eight older adults (72.0 ± 6.4 years; 5 female; 3 male) was evaluated. Vocal choice reaction times (cognitive task) were measured at standstill as well as during unperturbed and perturbed gait (motor task). The perturbation was administered using customized shoes instrumented to lower a small (18.4 mm high) aluminum flap suddenly under the medial or lateral forefoot during a single swing phase of 12 of 30 gait trials. The ankle inverted or everted an average of 10 or 9 degrees, respectively, depending on the flap deployed. Medial and lateral perturbations were randomized between the left and right feet. The results show that vocal choice reaction time was significantly prolonged by gait, both perturbed (614.7 ± 80.2 ms) and unperturbed (529.9 ± 119.3 ms), compared to standstill (332.8 ± 76.5 ms; p = 0.0015). Further, the prolongation associated with gait perturbation was significant, compared to that with unperturbed gait (p = 0.016). The kinematics of the first post-perturbation (recovery) step, with or without concomitant vocal choice reaction task performance, was not significantly different from those of the average step during unperturbed gait. We conclude that in healthy older adults, the requirement to respond to a gait challenge resulted in deterioration in the performance of a concurrent cognitive task as indicated by significant prolongation of response time in the vocal choice reaction task. In contrast, performance of the motor task was not adversely affected.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Nnodim JO,Kim H,Ashton-Miller JAdoi
10.1007/s00221-015-4533-0subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1077-84issue
4eissn
0014-4819issn
1432-1106pii
10.1007/s00221-015-4533-0journal_volume
234pub_type
杂志文章abstract：:Properties of otolith inputs to vestibulocerebellar neurons were investigated in 14 adult cats. In the vestibular nuclei, we recorded single-unit activities that responded orthodromically after stimulation of the utricular and/or saccular nerves and antidromically after stimulation of the cerebellum (uvula-nodulus and...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000424
更新日期：2000-09-01 00:00:00
abstract：:The Stroop test enables interference between color naming and reading to be studied. Protopapas et al. (2007) reported more errors in an interference task and longer reaction times in 12.5-year-old dyslexics; also more Stroop interference with lower reading skills. The present study uses a version of the Stroop with f...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2247-x
更新日期：2010-06-01 00:00:00
abstract：:Visual receptive field properties of neurons in the region of the thalamic internal medullary lamina were studied in alert cats while they fixated in various directions. In slightly more than 50% of the cells, the responsiveness of the cells was found to depend on the location of the stimulus with respect to the head-...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237535
更新日期：1980-01-01 00:00:00
abstract：:We previously described significant relationships between amplitude variations in slow brain potentials and timed between-press intervals (2.5 s). We suggested that these variations are neural traces of timing mechanisms. To determine which time processing stage is concerned, the current study examines whether these v...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1103-z
更新日期：2002-08-01 00:00:00
abstract：:This study employed neurophysiological methods to relate the condition of the corticospinal system with the voluntary control of lower-limb muscles in persons with motor-incomplete spinal cord injury. It consisted of two phases. In a group of ten healthy subjects, single and paired transcranial magnetic stimulation (T...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2190-9
更新日期：2005-06-01 00:00:00
abstract：:Plasticity of corticospinal tract (CST) activity likely plays a key role in motor function recovery after central nervous system (CNS) lesions. In non-injured adults, 30 min of repetitive common peroneal nerve stimulation (rCPnS) increases CST excitability by 40-50% and the effect persists for at least 30 min. The pre...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2607-1
更新日期：2011-04-01 00:00:00
abstract：:Sources of primary afferent depolarization (PAD) of skin afferents in the sural (Sur) nerve and of group-II muscle afferents in the posterior biceps and semitendinosus (PBST) nerve were compared at several sites, about 2 mm apart, within the L7-S2 segments in order to define areas of projection of sacral interneurons ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000429
更新日期：2000-08-01 00:00:00
abstract：:The active components of the quadrupedal diagonal stance response to rapid removal of the support from beneath a single limb were studied in cats to further define the mechanisms that trigger and generate the response. We recorded EMG activity from lateral gastrocnemius and tibialis anterior muscles in awake, behaving...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00249792
更新日期：1987-01-01 00:00:00
abstract：:Vibratory stimulation of the neck muscles can elicit illusory drift of a visual target; after vibration stops, motion in the opposite direction is perceived. This motion aftereffect (MAE) could be due to adaptation of proprioceptive mechanisms that encode head orientation, or at a stage where visual and proprioceptive...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-0910-7
更新日期：2007-07-01 00:00:00
abstract：:The factors controlling neurogenesis and differentiation of olfactory receptor cells in adults are poorly understood, although it is often stated that these cells undergo continual turnover after a predetermined lifespan. An interesting model in which to study mechanisms which control olfactory receptor neurogenesis a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247534
更新日期：1988-01-01 00:00:00
abstract：:Sleep disturbances impair cognitive functioning in typically developing populations. Children with attention-deficit/hyperactivity disorder (ADHD), a disorder characterized by impaired inhibitory control and attention, commonly experience sleep disturbances. Whether inhibitory impairments are related to sleep deficits...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-4906-7
更新日期：2017-05-01 00:00:00
abstract：:We have studied the ability of a quaternary antihistamine, thiazinamium, to inhibit the nociceptive sensitization that occurs early, during the first hour, following intraplantar injection of the polysaccharide carrageenin in the rat. Parallel studies were performed with an electrophysiological model (changes in respo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236307
更新日期：1987-01-01 00:00:00
abstract：:Slow eye movements were observed while the monkey fixated on a subject-stationary, small target light in front of a moving optokinetic drum in an attempt to suppress optokinetic nystagmus (OKN). These slow eye movements of low amplitude were directed opposite to the moving optokinetic stimulus and, hence, were not ide...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248564
更新日期：1987-01-01 00:00:00
abstract：:After partial (spared-root) or complete hindlimb deafferentation, locomotion and accurate limb placement during locomotion recover considerably. In the present study movement was studied during and after recovery to determine whether altered motor patterns could substitute for normal ones in the recovery of motor beha...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248226
更新日期：1988-01-01 00:00:00
abstract：:Within-arm somatotopy was identified in multiple motor areas of six normal human subjects who performed a visuomotor tracking task during positron emission tomography (PET) measurement of relative cerebral blood flow (relCBF). A randomly moving target, presented on a computer monitor, was continuously followed with th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229666
更新日期：1993-01-01 00:00:00
abstract：:The neuropeptide galanin (GAL) was injected intrathecally (i.t.) in decerebrate, spinalized, unanesthetized rats and its effect on the nocifensive flexor reflex was examined. The reflex, which was evoked by intense mechanical or thermal stimulation of the foot, was recorded from the ipsilateral hamstring muscles. I.t....
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248760
更新日期：1988-01-01 00:00:00
abstract：:The presence of discrete events during an interval to be estimated generally causes a dilation of perceived duration (event-filling effect). Here, we investigated this phenomenon in the thermal modality using multi-seconds (19 s) innocuous cool stimuli that were either constant (continuous interval) or fluctuating to ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4537-9
更新日期：2016-04-01 00:00:00
abstract：:We have previously established an fMRI task battery suitable for mapping the language processing network in children. Among the tasks used, the synonyms and the vowel identification task induced robust task-related activations in children with average language abilities; however, the fixed presentation time seems to b...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4473-8
更新日期：2016-03-01 00:00:00
abstract：:Wheat germ agglutinin-horseradish peroxidase (WGA-HRP) conjugate was injected into the lumbar or cervical spinal cord of adult cats in order to examine its usefulness as an anterograde tracer of long ascending spinal tracts. Heavily labeled fibers and terminal-like structures were found in restricted regions of the gr...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237154
更新日期：1983-01-01 00:00:00
abstract：:Motor imagery (MI - i.e., the mental representation of an action without physically executing it) stimulates brain motor networks and promotes motor learning after spinal cord injury (SCI). An interesting issue is whether the brain networks controlling MI are being reorganized with reference to spared motor functions....
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4114-7
更新日期：2015-01-01 00:00:00
abstract：:We examined the lower limb joint kinematics observed during pre- and postflight treadmill walking performed by seven subjects from three Space Shuttle flights flown between March 1992 and February 1994. Basic temporal characteristics of the gait patterns, such as stride time and duty cycle, showed no significant chang...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227650
更新日期：1996-11-01 00:00:00
abstract：:The purpose of this study was to determine whether the neuromuscular control of goal-directed movements is different for young and older adults with the upper and lower limbs. Twenty young (25.1 ± 3.9 years) and twenty older adults (71.5 ± 4.8 years) attempted to accurately match the displacement of their limb to a sp...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3868-2
更新日期：2014-06-01 00:00:00
abstract：:This study examines the process of learning to walk from a functional perspective. To move forward, one must generate and control propulsive forces. To achieve this, it is necessary to create and tune a distance between the centre of mass (CoM) and the centre of pressure (CoP) along the antero-posterior axis. We hypot...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4378-6
更新日期：2015-10-01 00:00:00
abstract：:Two versions of the hypothesis that discrete movements are produced by shifts in the system's equilibrium point are considered. The first suggests that shifts are monotonic and end near the peak velocity of movement, and the second presumes that they are nonmonotonic ("N-shaped") and proceed until the end of movement....
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00241503
更新日期：1995-01-01 00:00:00
abstract：:The present study tested the idea that the visuomotor systems mediating prehension do not have independent access to pictorial cues processed by perceptual mechanisms. Individuals with visual form agnosia, whose perceptual systems are compromised but who have intact visuomotor control, were examined to determine wheth...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005731
更新日期：1997-08-01 00:00:00
abstract：:The cortical anatomical substrates by which visual information may influence the frontal areas controlling reaching movements to visual targets were studied in monkeys. A reaching task was employed to characterize the arm-related regions of the frontal lobe. Injections of retrograde tracers into these physiologically ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228707
更新日期：1993-01-01 00:00:00
abstract：:The companion article (Sholomenko et al. 1991) described the brainstem locomoter regions in the bird where direct intracerebral injection of a number of putative excitatory neurochemicals, including cholinergic agonists, N-methyl-d-aspartate (NMDA) and Substance P, evoke locomotion. Using the same experimental protoco...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231753
更新日期：1991-01-01 00:00:00
abstract：:Studies undertaken in head-restrained animals have long implicated the omnipause neurons (OPNs) in the initiation of saccadic eye movements. These inhibitory neurons discharge tonically but cease firing just before and during saccades in all directions. By recording from OPNs in alert behaving head-unrestrained cats, ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00232210
更新日期：1990-01-01 00:00:00
abstract：:When someone grasps an object, the grasp depends on the intended object manipulation and usually facilitates it. If several object manipulation steps are planned, the first step has been reported to primarily determine the grasp selection. We address whether the grasp can be aligned to the second step, if the second s...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-4892-9
更新日期：2017-05-01 00:00:00
abstract：:Prior studies have shown that procedural learning is severely impaired in patients with diffuse cerebellar damage (cortical degeneration) as measured by the serial reaction time task (SRTT). We hypothesize that focal cerebellar lesions can also have lateralized effects on procedural learning. Our objective was to asse...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050374
更新日期：1998-05-01 00:00:00
