Intrathecal galanin at low doses increases spinal reflex excitability in rats more to thermal than mechanical stimuli.

Abstract:

:The neuropeptide galanin (GAL) was injected intrathecally (i.t.) in decerebrate, spinalized, unanesthetized rats and its effect on the nocifensive flexor reflex was examined. The reflex, which was evoked by intense mechanical or thermal stimulation of the foot, was recorded from the ipsilateral hamstring muscles. I.t. GAL increased reflex excitability significantly more to thermal than to mechanical stimuli. It is suggested that GAL, which is present in sensory fibers that innervate the skin, is released by the central terminals of cutaneous afferents that are much more sensitive to thermal than to mechanical stimuli.

journal_name

Exp Brain Res

authors

Wiesenfeld-Hallin Z,Villar MJ,Hökfelt T

doi

10.1007/BF00248760

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

663-6

issue

3

eissn

0014-4819

issn

1432-1106

journal_volume

71

pub_type

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