A "one size fits all" approach to language fMRI: increasing specificity and applicability by adding a self-paced component.

Abstract:

:We have previously established an fMRI task battery suitable for mapping the language processing network in children. Among the tasks used, the synonyms and the vowel identification task induced robust task-related activations in children with average language abilities; however, the fixed presentation time seems to be a drawback in participants with above- or below-average language abilities. This feasibility study in healthy adults (n = 20) was aimed at adapting these tasks to the individual level of each patient by implementing a self-paced stimulus presentation. The impact of using a block- versus an event-related statistical approach was also evaluated. The self-paced modification allowed our participants with above-average language abilities to process stimuli much faster than originally implemented, likely increasing task adherence. A higher specificity of the event-related analysis was confirmed by stronger left inferior frontal and crossed cerebellar activations. We suggest that self-paced paradigms and event-related analyses may both increase specificity and applicability.

journal_name

Exp Brain Res

authors

Máté A,Lidzba K,Hauser TK,Staudt M,Wilke M

doi

10.1007/s00221-015-4473-8

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

673-84

issue

3

eissn

0014-4819

issn

1432-1106

pii

10.1007/s00221-015-4473-8

journal_volume

234

pub_type

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