A "one size fits all" approach to language fMRI: increasing specificity and applicability by adding a self-paced component.


:We have previously established an fMRI task battery suitable for mapping the language processing network in children. Among the tasks used, the synonyms and the vowel identification task induced robust task-related activations in children with average language abilities; however, the fixed presentation time seems to be a drawback in participants with above- or below-average language abilities. This feasibility study in healthy adults (n = 20) was aimed at adapting these tasks to the individual level of each patient by implementing a self-paced stimulus presentation. The impact of using a block- versus an event-related statistical approach was also evaluated. The self-paced modification allowed our participants with above-average language abilities to process stimuli much faster than originally implemented, likely increasing task adherence. A higher specificity of the event-related analysis was confirmed by stronger left inferior frontal and crossed cerebellar activations. We suggest that self-paced paradigms and event-related analyses may both increase specificity and applicability.


Exp Brain Res


Máté A,Lidzba K,Hauser TK,Staudt M,Wilke M




Has Abstract


2016-03-01 00:00:00














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    abstract::A recent study from this laboratory has shown that brief transient ischemia (2 min 30 s) in normo- and hyperglycemic rats leads to moderate neuronal necrosis in CA1 cells of the hippocampus, of equal density in the two groups. However, hyperglycemic animals failed to depolarize during the ischemia, nor did they show a...

    journal_title:Experimental brain research

    pub_type: 杂志文章


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    更新日期:1997-03-01 00:00:00

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    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Paemeleire K,de Hemptinne A,Leybaert L

    更新日期:1999-06-01 00:00:00

  • Saccadic inhibition underlies the remote distractor effect.

    abstract::The remote distractor effect is a robust finding whereby a saccade to a lateralised visual target is delayed by the simultaneous, or near simultaneous, onset of a distractor in the opposite hemifield. Saccadic inhibition is a more recently discovered phenomenon whereby a transient change to the scene during a visual t...

    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Buonocore A,McIntosh RD

    更新日期:2008-10-01 00:00:00

  • Deficits of visual motion perception and optokinetic nystagmus after posterior suprasylvian lesions in the ferret (Mustela putorius furo).

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    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Hupfeld D,Distler C,Hoffmann KP

    更新日期:2007-10-01 00:00:00

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    abstract::It is known that TMS can induce blinking, but it is unknown to what extent and at what time TMS-induced blinking can cover the pupil. We applied single-pulse TMS with a leftward and rightward monophasic current through a round coil over the occipital pole in 8 healthy subjects, using high-speed video to monitor left o...

    journal_title:Experimental brain research

    pub_type: 杂志文章


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  • REM theta activity enhances inhibitory control in typically developing children but not children with ADHD symptoms.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


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  • Modulatory effects of high-frequency repetitive transcranial magnetic stimulation on the ipsilateral silent period.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Cincotta M,Giovannelli F,Borgheresi A,Balestrieri F,Zaccara G,Inghilleri M,Berardelli A

    更新日期:2006-06-01 00:00:00

  • Accuracy of spatial localization depending on head posture in a perturbed gravitoinertial force field.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


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  • Hippocampus and the blood supply to TE: parahippocampal pial section impairs visual discrimination learning in monkeys.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


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  • The contribution of fast corticospinal input to the voluntary activation of proximal muscles in normal subjects and in stroke patients.

    abstract::Although it is well known that the corticospinal system exerts more influence over distal (hand and fingers) than proximal (elbow and shoulder) upper limb muscles, differences in the importance of this system for voluntary activation of these muscle groups have not been demonstrated directly. Two investigations were c...

    journal_title:Experimental brain research

    pub_type: 杂志文章


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    更新日期:1999-12-01 00:00:00

  • Stability of large cell-medium cell clusters in the mature neostriatum.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


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  • Dynamical degrees of freedom and correlations in isometric finger force production.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: James EG

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    journal_title:Experimental brain research

    pub_type: 杂志文章


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  • Intracellular recordings from medial septal neurons during hippocampal theta rhythm.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


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    abstract::Adult-like fine control of cyclical motor patterns found in locomotion develops into adolescence. Single-leg hopping in place is one such motor pattern where children have demonstrated a reduced capacity to control horizontal motion and match metronome cues. These developmental differences might arise from immature in...

    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Beerse M,Wu J

    更新日期:2019-07-01 00:00:00

  • Effects of intracerebroventricular injections of free fatty acids, lysophospholipids, or platelet activating factor in a mouse model of orofacial pain.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Vahidy WH,Ong WY,Farooqui AA,Yeo JF

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  • Neural mechanism of selective finger movement independent of synergistic movement.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Aoyama T,Kaneko F,Ohashi Y,Kohno Y

    更新日期:2019-12-01 00:00:00

  • Optokinetic nystagmus during selective retinal stimulation.

    abstract::Nystagmic eye movements in response to selective optokinetic stimulation of different parts of the retina were studied in normal human subjects by two methods: 1. a digital computer controlled by the eye movement signal was used to generate an optokinetic display which stimulated only the peripheral retina, simulating...

    journal_title:Experimental brain research

    pub_type: 杂志文章


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    journal_title:Experimental brain research

    pub_type: 杂志文章


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  • The postnatal development of somatosensory callosal connections after partial lesions of somatosensory areas.

    abstract::The distribution of S1 (first somatosensory area) and S2 (second somatosensory area) neurons projecting to the contralateral S2 was studied with horseradish peroxidase in normal adult cats and in cats aged between 129 and 248 days in which the injected S2 area had been deprived of some of its input by an earlier lesio...

    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Caminiti R,Innocenti GM

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  • Kinaesthetic role of muscle afferents in man, studied by tendon vibration and microneurography.

    abstract::The characteristics of vibration-induced illusory joint movements were studied in healthy human subjects. Unseen by the subject, constant frequency vibration trains applied to the distal tendon of the Triceps or Biceps induced an almost constant velocity illusory movement of the elbow whose direction corresponded to t...

    journal_title:Experimental brain research

    pub_type: 杂志文章


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  • Antagonist motor responses correlate with kinesthetic illusions induced by tendon vibration.

    abstract::In humans, vibration applied to muscle tendons evokes illusory sensations of movement that are usually associated with an excitatory tonic response in muscles antagonistic to those vibrated (antagonist vibratory response or AVR). The aim of the present study was to investigate the neurophysiological mechanisms underly...

    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Calvin-Figuière S,Romaiguère P,Gilhodes JC,Roll JP

    更新日期:1999-02-01 00:00:00

  • Sites of action of testosterone in the brain of the female primate.

    abstract::Thaw-mount autoradiography was used to map target neurons for tritiated steroids in the brains of ovariectomized rhesus monkeys. In five females, studies were performed 60 min after the administration of 3H-estradiol. Of these, two females were pretreated for five days with daily injections of 2 mg testosterone propio...

    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Rees HD,Bonsall RW,Michael RP

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  • Neuronal pathways from low-threshold hindlimb cutaneous afferents to motoneurons innervating trunk muscles in low-spinal cats.

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    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Wada N,Shikaki N,Tokuriki M,Kanda K

    更新日期:1999-10-01 00:00:00

  • Low-frequency galvanic vestibular stimulation evokes two peaks of modulation in skin sympathetic nerve activity.

    abstract::We have previously shown that sinusoidal galvanic vestibular stimulation (sGVS), delivered bilaterally at 0.2-2.0 Hz, evokes a potent entrainment of sympathetic outflow to muscle and skin. Most recently, we showed that stimulation at 0.08-0.18 Hz generates two bursts of modulation of muscle sympathetic nerve activity ...

    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Hammam E,Dawood T,Macefield VG

    更新日期:2012-06-01 00:00:00

  • Cognitive-perceptual load modulates hand selection in left-handers to a greater extent than in right-handers.

    abstract::Previous studies have proposed that selecting which hand to use for a reaching task appears to be modulated by a factor described as "task difficulty," defined by either the requirement for spatial precision or movement sequences. However, we previously reported that analysis of the movement costs associated with even...

    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Liang J,Wilkinson KM,Sainburg RL

    更新日期:2019-02-01 00:00:00

  • Regulation of α-secretase ADAM10 expression and activity.

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    journal_title:Experimental brain research

    pub_type: 杂志文章,评审


    authors: Endres K,Fahrenholz F

    更新日期:2012-04-01 00:00:00

  • Estimation of premotor synaptic drives to simulated abducens motoneurons for control of eye position.

    abstract::The firing rate of an abducens motoneuron (AbMN) is linearly related to eye position with slope K, above recruitment threshold theta. Within the AbMN population K increases as theta increases. It is possible that these properties depend on the synaptic drives generated by the major premotor inputs to AbMNs, namely pos...

    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Hazel TR,Sklavos SG,Dean P

    更新日期:2002-09-01 00:00:00

  • Adaptational effects during human split-belt walking: influence of afferent input.

    abstract::The modification of the normal locomotor pattern of humans was investigated using a split-belt locomotion protocol (treadmill belt speeds of 4.5 km/h and 1.5 km/h for the right and left legs, respectively) and also by changing afferent input from the legs (30% reduction or increase in body weight by suspending subject...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章


    authors: Jensen L,Prokop T,Dietz V

    更新日期:1998-01-01 00:00:00

  • Transplantation of fetal lateral geniculate nucleus to the occipital cortex: connectivity with host's area 17.

    abstract::The developing lateral geniculate complex was excised from fetal albino rats at 18 days of gestation and implanted into the occipital cortex of host animals at 5 days of postnatal age. Groups of host animals were sacrificed at 10, 20 and 30 days following this procedure. The transplant tissue of selected animals was s...

    journal_title:Experimental brain research

    pub_type: 杂志文章


    authors: Matthews MA

    更新日期:1985-01-01 00:00:00