Abstract:
:The present study was performed to explore the antinociceptive effects of the galanin receptor 1 agonist M617 in lateral habenula complex in rats. Intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of galanin induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of the galanin receptor 1 agonist M617 also induced dose-dependent increases in HWLs to noxious thermal and mechanical stimulations in rats. Interestingly, there were no significant differences between the antinociceptive effects induced by intra-lateral habenula injection of 2 nmol of M617 and 2 nmol of galanin. The results indicate that galanin receptor 1 may be involved in the galanin-induced antinociceptive effects in the lateral habenula.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Fu LB,Wang Y,Sun XX,Liu XX,Wang Y,Zhuang Wdoi
10.1007/s00221-015-4480-9subject
Has Abstractpub_date
2016-02-01 00:00:00pages
493-7issue
2eissn
0014-4819issn
1432-1106pii
10.1007/s00221-015-4480-9journal_volume
234pub_type
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