Antinociceptive effects induced by intra-lateral habenula complex injection of the galanin receptor 1 agonist M617 in rats.

Abstract:

:The present study was performed to explore the antinociceptive effects of the galanin receptor 1 agonist M617 in lateral habenula complex in rats. Intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of galanin induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of the galanin receptor 1 agonist M617 also induced dose-dependent increases in HWLs to noxious thermal and mechanical stimulations in rats. Interestingly, there were no significant differences between the antinociceptive effects induced by intra-lateral habenula injection of 2 nmol of M617 and 2 nmol of galanin. The results indicate that galanin receptor 1 may be involved in the galanin-induced antinociceptive effects in the lateral habenula.

journal_name

Exp Brain Res

authors

Fu LB,Wang Y,Sun XX,Liu XX,Wang Y,Zhuang W

doi

10.1007/s00221-015-4480-9

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

493-7

issue

2

eissn

0014-4819

issn

1432-1106

pii

10.1007/s00221-015-4480-9

journal_volume

234

pub_type

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