Abstract:
:Many age-related degenerative diseases of the central nervous system (CNS) increasingly appear to have similarities in their underlying causes. By applying knowledge between disorders, and in particular between degenerative diseases of different components of the CNS (e.g. the eye and the brain), we can begin to elucidate general mechanisms of neural degeneration. Age-related macular degeneration and glaucoma, two diseases of retinal neurons, which have recently been discussed in view of their common mechanisms with Alzheimer's disease, highlight this perspective. This review discusses the common roles of the complement system (an immunological system) and glial cells (providing, amongst other functions, trophic support to neurons) in these three disorders. A number of facets of these systems would seem to be involved in the mechanisms of degeneration in at least two of the three diseases considered here. Regulatory proteins of the complement system (such as factor H), neurotrophin levels, and the interaction of microglia with the complement system in particular may be general to all three presentations of neural degeneration. Investigating the functioning of these fundamental systems across different diseases exemplifies the importance of considering advances in knowledge across a wider base than specific disease pathology. This may give insights both for understanding the function of these supporting systems and providing an avenue for developing future therapeutic targets general to neural degenerative diseases.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Harvey H,Durant Sdoi
10.1007/s00221-014-4078-7subject
Has Abstractpub_date
2014-11-01 00:00:00pages
3363-77issue
11eissn
0014-4819issn
1432-1106journal_volume
232pub_type
杂志文章,评审abstract::The contribution of ventral stream information to the variability of movement has been the focus of much attention, and has provided numerous researchers with conflicting results. These results have been obtained through the use of discrete pointing movements, and as such, do not offer any explanation regarding how ve...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0453-3
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abstract::Six cats were reared with surgically produced squint or atropinisation of one eye during the sensitive period of development. Five cats were reared without an ocular interference but in the same environment as the experimental cats. Four of these normally reared cats provided control data for perikaryal size. When the...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235784
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abstract::The present experiment investigated the effects of aging on emotional behavior, without concomitant influences from any previous behavioral manipulation apart from weighing the rats. Anxiety-related behaviors were measured in the elevated plus-maze (EPM). Performance in the open field (OF) was also assessed to control...
journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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abstract::The efferent subcortical connections of the dorsomedial cortical visual area (DM) in the owl monkey were determined by tracing degenerating axons following lesions or by tracing axonal pathways following injection of radioactively labeled proline. Areas of termination included structures which are known to receive inp...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238705
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abstract::The goal of this study was to determine the effect of changes in core body temperature on the resting discharge rate and sensitivity of vestibular-nerve afferents. Extracellular recordings were made from vestibular-nerve afferents innervating the semicircular canals in anesthetized C57BL/6 mice maintained at a core bo...
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abstract::Single neurons in the inferior colliculus of the Greater Horseshoe bat, Rhinolophus ferrumequinum, showed two broad categories of response patterns to sinusoidally frequency (SFM) or amplitude (SAM) modulated stimuli. Tonic responding cells (best excitatory frequency (BEF) between 10 and 90 kHz) showed a rough sinusoi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238345
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050467
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239728
更新日期:1978-06-19 00:00:00
abstract::Cellular relationships between serotonin (5-HT) axons and tyrosine hydroxylase (TH)-containing neurons were examined by combined (3H)5-HT uptake radioautography and TH immunocytochemistry in the medial zona incerta (ZI) of adult rats, 7 and 50 days after an intracerebral injection of 5,7-Dihydroxytryptamine (5,7-DHT)....
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00250592
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abstract::We explored digit coordination during the acceleration phase of a quick lifting movement of a hand-held horizontal object. We tested three hypotheses related to: (1) the scaling of mechanical variables produced by the hand with changes in the external load, torque, and moment of inertia; (2) changes in the safety marg...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3215-4
更新日期:2012-10-01 00:00:00
abstract::The current study examined whether the amount and location of available movement information influenced the stability of visuomotor coordination. Participants coordinated a handheld pendulum with an oscillating visual stimulus in an inphase and antiphase manner. The effects of occluding different amounts of phase at d...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1982-3
更新日期:2012-09-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228869
更新日期:1990-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229320
更新日期:1990-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241967
更新日期:1995-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0563-y
更新日期:2006-11-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1966-3
更新日期:2010-01-01 00:00:00
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journal_title:Experimental brain research
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更新日期:2013-07-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1321-4
更新日期:2003-02-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2668-1
更新日期:2011-09-01 00:00:00
abstract::It has previously been found that in fast point-to-point arm movements, proprioceptive feedback is centrally suppressed at the beginning of movement and is facilitated at a time that is correlated with temporal parameters of the planned movement. Here, we show that this correlation holds when subjects are explicitly i...
journal_title:Experimental brain research
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doi:10.1007/s00221-009-1967-2
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abstract::Sensorimotor synchronization is hypothesized to arise through two different processes, associated with continuous or discontinuous rhythmic movements. This study investigated synchronization of continuous and discontinuous movements to different pacing signals (auditory or visual), pacing interval (500, 650, 800, 950 ...
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pub_type: 杂志文章
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journal_title:Experimental brain research
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