Abstract：
:In visual cortex of normal adult rabbits, callosal projections are restricted to a 2 mm wide band at the area 17/18 border. In adult rabbits which are monocularly enucleated (ME) on the day of birth, the callosal zone extends 4 mm into the medial region of area 17 in the cortex ipsilateral to the remaining eye. In this study, the function of these anomalous callosal projections in ME rabbits was investigated using electrophysiological techniques. A microelectrode was placed in the visual cortex ipsilateral to the enucleated eye at the 17/18 border, bipolar stimulating electrodes were placed in a homotopic location in the contralateral cortex, and averaged evoked responses (AERs) to stimulation were recorded. The stimulating electrodes were then moved mediolaterally in 1 mm steps, and the AERs were recorded for each location of the stimulating electrodes. In the normal rabbit, a maximal short latency evoked response was recorded when the stimulating electrodes were at a location homotopic to the recording electrode. When the stimulating electrodes were moved a distance of 1 mm or more from this optimal position, this short latency response was either absent or dramatically decreased in amplitude, reflecting the precise topographic pattern of the normal callosal projection. In contrast, in ME rabbits, a consistent response was evoked at the 17/18 border when the stimulating electrodes were moved as much as 3 mm medial to the homotopic position. Since antidromically activated responses and both pre- and postsynaptic orthodromically activated responses contribute to the AER, recordings were also made from single cells in some animals.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Clarke RJ,Datskovsky BW,Grigonis AM,Murphy EHdoi
10.1007/BF00231662keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
296-302issue
2eissn
0014-4819issn
1432-1106journal_volume
91pub_type
杂志文章abstract：:Retinal ganglion cells of adult cats have the potential to regenerate their axons into autografted peripheral nerve. Two months after transplantation of the sciatic nerve to the axotomized optic stump, regenerated axons were labeled anterogradely with biocytin, and myelin formation by Schwann cells was examined electr...
journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
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更新日期：1989-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-09-01 00:00:00
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更新日期：2001-11-01 00:00:00
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更新日期：2007-02-01 00:00:00
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