Abstract：
:In cats anaesthetised with pentobarbitone, the effect of inhibitors of the in vitro cellular uptake of GABA were tested on the responses of single central neurones to GABA and other depressant amino acids. (4)- AND (-)-nepecotic acid, (4)-2,4-diaminobutyric acid (DABA) and 2,2-dimethyl-beta-alanine, enhanced the action of GABA on spinal, cerebellar and cerebral cortical neurones. In the spinal cord DABA, and to a less estent (-)-nipecotic acid, enhanced the action of beta-alanine, whereas the actions of glycine and taurine were unaffected by DABA and reduced by (-)-nipecotic acid. In the cerebellum and cerebral cortex, these two substances enhanced the action of GABA, usually to a greater extent than that of beta-alanine and taurine, although this specificity was not marked. The GABA-mediated basket cell inhibition of Purkinje cells in the cerebellum was unaffected by DABA and (-)-nipecotic acid, and neither substance appears suitable for determining the role of uptake processes in the inactivation of synapitcally released GABA. Quantitatively these in vivo results agree more closely with recent vitro uptake studies in cat tissue than the previously published data on rat cerebral cortex and dorsal root ganglia, and the observations provide further evidence for the importance of cellular uptake in maintaining low extraneuronal concentrations of inhibitory amino acid transmitters.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Curtis DR,Game CJ,Lodge Ddoi
10.1007/BF00241731subject
Has Abstractpub_date
1976-06-30 00:00:00pages
413-28issue
4eissn
0014-4819issn
1432-1106journal_volume
25pub_type
杂志文章abstract：:Interval timing deficiencies in Parkinson's disease (PD) patients have been a matter of debate. Here we test the possibility of PD heterogeneity as a source for this discrepancy. Temporal performance of PD patients and control subjects was assessed during two interval tapping tasks and during a categorization task of ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-1097-7
更新日期：2008-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237283
更新日期：1984-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2138-0
更新日期：2005-05-01 00:00:00
abstract：UNLABELLED:Saccadic eye movements made to remembered locations in the dark show a distinct up-shift in macaque monkey, and slight upward bias in humans (Gnadt et al. 1991). This upward bias created in the visual spatial mapping of a saccade may be translated downstream in a hand/touch movement. This error could possibl...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2033-8
更新日期：2005-01-01 00:00:00
abstract：:Changes in the direction of the line of sight (gaze) allow successive sampling of the visual environment. Saccadic eye movements accomplish this goal when the head does not move. Medium-lead burst neurons (MLBs) in the paramedian pontine reticular formation (PPRF) discharge a high frequency burst of action potentials ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2823-8
更新日期：2011-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3815-7
更新日期：2014-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236643
更新日期：1980-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0453-3
更新日期：2006-09-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05583-2
更新日期：2019-09-01 00:00:00
abstract：:Quantitative autoradiography was used to examine central binding sites for L-[3H]glutamate in amygdaloid-kindled rats since receptors for excitatory amino acids have been implicated in epileptiform activity and seizure behaviors. In tissue from rats killed five days after two kindled seizures, the ipsilateral hippocam...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231751
更新日期：1991-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3763-2
更新日期：2014-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-2338-2
更新日期：2005-06-01 00:00:00
abstract：:Feedback about error or reward is regarded essential for aiding learners to acquire a perceptual-motor skill. Yet, when a task has redundancy and the mapping between execution and performance outcome is unknown, simple error feedback does not suffice in guiding the learner toward the optimal solutions. The present stu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4251-7
更新日期：2015-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2202-x
更新日期：2010-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247293
更新日期：1987-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2451-8
更新日期：2011-01-01 00:00:00
abstract：:To explore visual space, we make saccades, vergence, and, most frequently, combined saccade-vergence eye movements. The initiation of saccades is well studied, while that of vergence is less explored. Saccade latency is influenced by the fixation task: when the target appears simultaneously with the offset of the fixa...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1670-7
更新日期：2004-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238784
更新日期：1983-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00340490
更新日期：1986-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00242177
更新日期：1995-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3781-0
更新日期：2014-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-005-0080-4
更新日期：2006-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1241-3
更新日期：2002-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4520-5
更新日期：2016-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0614-4
更新日期：2007-01-01 00:00:00
abstract：:Hand muscle reflexes following muscle stretch and electrical nerve stimulation show a typical pattern consisting of short- and long-latency reflexes. The present investigation was designed to test reflexes following pure cutaneous stimulation. Air puffs were delivered to the palmar tip and the nail bed of the first, s...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00242189
更新日期：1995-01-01 00:00:00
abstract：:Several experiments have suggested that similar physiological substrates are involved in movement execution and motor imagery, and that the same laws of movement control apply to both processes. Using a mental chronometry paradigm, we examined the effects of movement direction and added mass on the duration of actual ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1012-1
更新日期：2002-04-01 00:00:00
