Abstract:
:Quantitative autoradiography was used to examine central binding sites for L-[3H]glutamate in amygdaloid-kindled rats since receptors for excitatory amino acids have been implicated in epileptiform activity and seizure behaviors. In tissue from rats killed five days after two kindled seizures, the ipsilateral hippocampus, entorhinal, perirhinal and parietal cortices had significantly (35-100%) greater densities of binding sites for L-[3H]glutamate than the opposite, contralateral side or operated, unstimulated controls. These regions receive excitatory inputs from the amygdala via the entorhinal cortex. Dissociation constants were not altered and significant differences were not observed in the binding parameters for L-[3H]glutamate between control and kindled rats or ipsilateral and contralateral sides of the amygdala, corpus striatum, nucleus accumbens or substantia nigra. The proportion and affinity of N-methyl-D-aspartate (NMDA)-sensitive binding sites for L-[3H]glutamate was unchanged after kindling, as were the relative proportions of kainate- and AMPA-(DL-alpha-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid) sensitive sites. However, the density of NMDA and non-NMDA receptor subtypes was increased in the ipsilateral hippocampus, entorhinal, perirhinal and parietal cortices of kindled rats. These findings of specific, unilateral glutamate receptor up-regulation may indicate adaptive responses to the enhanced excitation found in kindling, and are consistent with other neuronal changes reported in early kindling.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Cincotta M,Young NA,Beart PMdoi
10.1007/BF00231751subject
Has Abstractpub_date
1991-01-01 00:00:00pages
650-8issue
3eissn
0014-4819issn
1432-1106journal_volume
85pub_type
杂志文章abstract::Insulin-like growth factor-1 (IGF-1) is an endogenous peptide transported across the blood brain barrier that is protective in several brain injury models, including an acute animal model of Parkinson's disease (PD). Motor deficits in PD are due largely to the progressive loss of nigrostriatal dopaminergic neurons. Th...
journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::The present study assessed changes in perceived heaviness of weights lifted by the thumb, index, ring and little fingers during anaesthesia of the "lifting" digit. Subjects (n = 19) lifted weights solely by flexion of the distal joint of the digit, using a bilateral weight-matching paradigm. Changes in perceived heavi...
journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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doi:10.1007/s00221-004-2119-3
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235660
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:1978-04-14 00:00:00
abstract::Many previous studies have demonstrated the existence of neurons with tremor-frequency activity ("tremor cells") in the thalamus of Parkinson's disease (PD) patients and these neurons are presumed to play a role in the pathogenesis of tremor. Since a major input to motor thalamus (Voa and Vop) is from the internal seg...
journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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更新日期:1999-04-01 00:00:00
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journal_title:Experimental brain research
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更新日期:2001-05-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00