Abstract:
:The cerebrovascular consequences of the gentle restraint commonly used for the measurement of local cerebral blood flow (LCBF) in conscious rats has been tested by using two drugs, propranolol and diazepam. Propranolol induced small LCBF decreases in 7 structures suggesting that the cerebral circulation was partially controlled by the activation of intra or extracerebral aminergic pathways in this protocol. Sedative doses of diazepam reduced LCBF in most of the structures but anxiolytic doses increased it in 4 structures. This effect may be due to a regionally differentiated modification of activity in the brain due to the selective inhibition of limbic structures by diazepam. Since propranolol and diazepam induced only small changes, the LCBF of gently restrained rats appeared to be minimally affected by the stressful situation imposed by the protocol.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Lasbennes F,Seylaz Jdoi
10.1007/BF00235660subject
Has Abstractpub_date
1986-01-01 00:00:00pages
169-72issue
1eissn
0014-4819issn
1432-1106journal_volume
63pub_type
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