Abstract：
:Previous work has highlighted the role of haptic feedback for manual dexterity, in particular for the control of precision grip forces between the index finger and thumb. It is unclear how fine motor skills involving more than just two digits might be affected, especially given that loss of sensation from the hand affects many neurological patients, and impacts on everyday actions. To assess the functional consequences of haptic deficits on multi-digit grasp of objects, we studied the ability of three rare individuals with permanent large-fibre sensory loss involving the entire upper limb. All three reported difficulties in everyday manual actions (ABILHAND questionnaire). Their performance in a reach-grasp-lift task was compared to that of healthy controls. Twenty objects of varying shape, mass, opacity and compliance were used. In the reach-to-grasp phase, we found slower movement, larger grip aperture and less dynamic modulation of grip aperture in deafferented participants compared to controls. Hand posture during the lift phase also differed; deafferented participants often adopted hand postures that may have facilitated visual guidance, and/or reduced control complexity. For example, they would extend fingers that were not in contact with the object, or fold these fingers into the palm of the hand. Variability in hand postures was increased in deafferented participants, particularly for smaller objects. Our findings provide new insights into how the complex control required for whole hand actions is compromised by loss of haptic feedback, whose contribution is, thus, highlighted.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Miall RC,Rosenthal O,Ørstavik K,Cole JD,Sarlegna FRdoi
10.1007/s00221-019-05583-2subject
Has Abstractpub_date
2019-09-01 00:00:00pages
2167-2184issue
9eissn
0014-4819issn
1432-1106pii
10.1007/s00221-019-05583-2journal_volume
237pub_type
杂志文章abstract：:This study examined modulation of corticospinal excitability during both actual and imagined movements. Seven young healthy subjects performed actual (3-50% maximal voluntary contractions) and imagined index finger force production, and rest. Individual responses to focal transcranial magnetic stimulation (TMS) in fou...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0809-8
更新日期：2007-05-01 00:00:00
abstract：:Single-neuron activities were recorded in the hindlimb region of the primary somatosensory cortex and part of area 5 in awake Japanese monkeys. A total of 1050 units were isolated from five hemispheres of four animals. Receptive fields (RFs) and submodalities were identified for 90% of isolated neurons in areas 3a and...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000464
更新日期：2000-09-01 00:00:00
abstract：:Dopamine and somatostatin-14 (SRIF) were incubated with a membrane fraction of rat caudate-putamen (CP) tissue in an adenylate cyclase assay in order to examine the D-1-receptor coupled adenylate cyclase activity 5 days and 3 weeks after unilateral ablation of the left frontal and lateral cortex. Five days after decor...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248805
更新日期：1987-01-01 00:00:00
abstract：:Single cell activity was recorded from the putamen in rhesus monkeys (Macaca mulatta) performing limb movements made both with and without a preceding preparatory "set" concerning the impending direction of movement. The monkeys were trained to perform an elbow step-tracking task, each trial of which required the subj...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247293
更新日期：1987-01-01 00:00:00
abstract：:The static ocular torsional position of both eyes of 23 patients was measured by means of fundus photographs one day before and one week after unilateral vestibular neurectomy for the treatment of acoustic neuroma, Ménière's disease or paroxysmal vertigo. The results showed that in all patients the vestibular neurecto...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230003
更新日期：1991-01-01 00:00:00
abstract：:Projections from the posterior thalamic regions to the striatum were studied in the cat by the anterograde tracing method after injecting wheat germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) into the caudalmost regions of the lateroposterior thalamic nucleus (caudal LP), suprageniculate nucleus (Sg) and ma...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235934
更新日期：1985-01-01 00:00:00
abstract：:Vigilance is the ability to sustain attention to information for prolonged periods of time, particularly in environments where critical signals may be rare. Recent research in the domain of mind-wandering has suggested that processes associated with mind-wandering may underpin the typical decline in vigilance task per...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5438-5
更新日期：2019-02-01 00:00:00
abstract：:Our previous studies showed that a fully extended finger, wrist, and elbow became a flexed phantom hand and arm with ischemic anesthesia, and vice versa (Inui et al. in J Physiol 589:5775-5784, 2011, Exp Brain Res 221:369-375, 2012a, Exp Brain Res 218:487-494, 2012b). It was anticipated that if the ankle and knee were...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3460-1
更新日期：2013-05-01 00:00:00
abstract：:Large neurons of the mouse caudate nucleus contain profuse Nissl material, have a maximal pole-to-pole diameter of up to 25 micron, occur preferentially within a central or CORE zone of the neostriatum, and are almost always located within territories delimited by medium-sized clustered neurons. Examination of coronal...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235886
更新日期：1982-01-01 00:00:00
abstract：:Mammalian muscle spindles show persistent after-effects following conditioning stretch or fusimotor stimulation. Most previous observations have been carried out on primary endings of spindles and using dynamic fusimotor stimulation. We report here observations on after-effects produced either by conditioning stretch ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237676
更新日期：1985-01-01 00:00:00
abstract：:The results of this study show that the different receptive fields of multisensory neurons in the cortex of the cat anterior ectosylvian sulcus (AES) were in spatial register, and it is this register that determined the manner in which these neurons integrated multiple sensory stimuli. The functional properties of mul...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227844
更新日期：1992-01-01 00:00:00
abstract：:Albino mammals show very characteristic deficits in their optokinetic system, and albino ferrets are even optokinetically blind. To investigate the neuronal causes for this defect we compared the morphology of retinal slip cells in the pretectal nucleus of the optic tract and the dorsal terminal nucleus of the accesso...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210100832
更新日期：2001-10-01 00:00:00
abstract：:Dementia due to cerebral ischemic lesions is relatively common in the elderly. Since many of these lesions are probably caused by emboli, studying emboli-induced cerebral lesions in rabbits should, hopefully, provide information that is useful when searching for a means of preventing and treating vascular dementia in ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050622
更新日期：1999-01-01 00:00:00
abstract：:Tone bursts produced bands of selective 2-[14C]-deoxyglucose labelling in the inferior colliculus (IC) of the awake monkey. Low tone frequencies produced labelling in dorsal regions and high tone frequencies produced labelling in ventral regions. The position of the bands coincided with the position of a single unit w...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237983
更新日期：1984-01-01 00:00:00
abstract：:Changes in the direction of the line of sight (gaze) allow successive sampling of the visual environment. Saccadic eye movements accomplish this goal when the head does not move. Medium-lead burst neurons (MLBs) in the paramedian pontine reticular formation (PPRF) discharge a high frequency burst of action potentials ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2823-8
更新日期：2011-10-01 00:00:00
abstract：:Recent studies suggest that recreational use of cocaine is associated with significant impairments in the same cognitive control functions that are affected by chronic use. Here we tested whether recreational cocaine use can impact the emergence and resolution of response conflict in conflict-inducing tasks. Recreatio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3724-9
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:To examine the accuracy and latency of reflexive saccades to vibratory stimulation of the fingertips made by normal human subjects and to compare the findings to those of visually guided saccades. METHODS:Eye movements were recorded using infrared oculography. Stimuli were presented via an array of audiometric...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1749-1
更新日期：2004-02-01 00:00:00
abstract：:Prior studies identify two cortical areas, posterior parahippocampal cortex and retrosplenial cortex, that preferentially activate to images of real-world scenes compared to images of other meaningful visual stimuli such as objects and faces. Behavioral and computational studies suggest that sub-categories of real-wor...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0766-2
更新日期：2007-05-01 00:00:00
abstract：:Earlier studies have suggested an impairment in the attention and eye movement control of children with ADHD. An important phenomenon in the control of attentional shifts and eye movements is the inhibition of return (IOR), which states that our brain works in a way that prevents our attention from returning to a spat...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1362-8
更新日期：2003-03-01 00:00:00
abstract：:Hemi-seesaw nystagmus (hemi-SSN) is a jerk-waveform nystagmus with conjugate torsional and disjunctive vertical components. Halmagyi et al. in Brain 117(Pt 4):789-803 (1994), reported hemi-SSN in patients with unilateral lesions in the vicinity of the Interstitial Nucleus of Cajal (INC) and suggested that an imbalance...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2376-2
更新日期：2010-09-01 00:00:00
abstract：:Many activities of daily living involve multi-digit, voluntary rotational manipulations of grasped objects. Yet, only a few studies have focused on coordination of individual fingertip forces during such tasks. The objective of this study was to investigate individual digit contributions to a three-digit task in which...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4289-6
更新日期：2015-07-01 00:00:00
abstract：:The organization of corticocortical connections in the representation of the forepaw in cat primary somatosensory cortex (SI) was studied following injections of various tracers into different cortical cytoarchitectonic areas. Small injections of horseradish peroxidase, wheat germ agglutinin-conjugated HRP, Phaseolus ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227839
更新日期：1992-01-01 00:00:00
abstract：:Cellular relationships between serotonin (5-HT) axons and tyrosine hydroxylase (TH)-containing neurons were examined by combined (3H)5-HT uptake radioautography and TH immunocytochemistry in the medial zona incerta (ZI) of adult rats, 7 and 50 days after an intracerebral injection of 5,7-Dihydroxytryptamine (5,7-DHT)....
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00250592
更新日期：1988-01-01 00:00:00
abstract：:Extracellular unit recording was employed to study the axonal properties and efferent projections of antidromically identified neurons in the olfactory peduncle (OP) region of a primitive eutherian macrosmatic mammal, the south american armadillo (Chaetophractus vellerosus). Of 72 cells which satisfied the criteria fo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00340490
更新日期：1986-01-01 00:00:00
abstract：:Through an experimental study of the stability properties of the human neuromuscular system while it performs simple point-to-point arm movements, this paper evaluates the concepts of equilibrium and virtual trajectories as a means of executing movement of the arm. Human subjects grasped the instrumented handle of a t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228024
更新日期：1995-01-01 00:00:00
abstract：:Immunoreactive TRH-containing neurons and their synaptic associations were studied electron microscopically in the paraventricular nucleus (PVN) and dorsomedial nucleus (DMH) of the rat hypothalamus. In propylthiouracil (PTU)-treated rats, the immunoreactive cell bodies in the PVN appeared to be activated, showing a h...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237473
更新日期：1986-01-01 00:00:00
abstract：:This study examined the variability in movement end points in a task in which human subjects reached to targets in different locations on a horizontal surface. The primary purpose was to determine whether patterns in the variable errors would reveal the nature and origin of the coordinate system in which the movements...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00241415
更新日期：1994-01-01 00:00:00
abstract：:Explant cultures of rat spinal cord, brain stem and cerebellum were used to visualize GABAA-receptors by means of immunohistochemistry. For these studies we have incubated the cultures with the monoclonal antibody bd 17 against the beta-subunit of the GABAA/benzodiazepine/chloride channel complex. In spinal cord cultu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228810
更新日期：1990-01-01 00:00:00
abstract：:In this work a statistical study is made of the final outcome of the quantification of the nerve cell labelling in the adult, after prenatal injection of tritiated thymidine. This outcome is presented in the form of histograms which are the superposition of elementary Poisson distributions. A theoretical model, based...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235410
更新日期：1975-01-01 00:00:00
abstract：:The acute and subacute effects of intracerebroventricularly (ICV) administered nerve growth factor (NGF) or brain-derived neurotrophic factor (BDNF) on locomotor activity were evaluated in awake adult rats. Immediately after ICV injection through an implanted cannula, locomotor activity was measured by a computerized ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005759
更新日期：1997-09-01 00:00:00
