N-tert-butyl-alpha-phenylnitrone reduces the number of microinfarctions in the rabbit brain cortex.

Abstract:

:Dementia due to cerebral ischemic lesions is relatively common in the elderly. Since many of these lesions are probably caused by emboli, studying emboli-induced cerebral lesions in rabbits should, hopefully, provide information that is useful when searching for a means of preventing and treating vascular dementia in humans. Using magnetic resonance imaging we have found that N-tert-butyl-alpha-phenyl-nitrone (a free radical scavenger) reduced the number of emboli-induced cerebral microinfarctions in the rabbit cortex but did not have any impact on the number of infarctions found in the subcortical structures. The results suggest that significant amount of free radicals are produced in the ischemic foci located in the cortex, but not in the ischemic foci located in the subcortical structures. This finding may be of importance when considering treatments for cerebral ischemia in humans.

journal_name

Exp Brain Res

authors

Roos MW,Ericsson A

doi

10.1007/s002210050622

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

271-2

issue

2

eissn

0014-4819

issn

1432-1106

journal_volume

124

pub_type

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