Myelination of regenerated optic fibers in peripheral nerve graft of adult cats.

Abstract:

:Retinal ganglion cells of adult cats have the potential to regenerate their axons into autografted peripheral nerve. Two months after transplantation of the sciatic nerve to the axotomized optic stump, regenerated axons were labeled anterogradely with biocytin, and myelin formation by Schwann cells was examined electron microscopically. Both myelinated and unmyelinated fibers were labeled with biocytin. Among 511 axons labeled in three grafts, 96 fibers (18.8%) were myelinated and 415 (81.2%) were unmyelinated. Mean diameter with SD of myelinated fibers was 1.28 +/- 0.39 micron (range 0.71-2.47) and that of unmyelinated fibers was 0.76 +/- 0.38 micron (range 0.18-2.46). The ratio of inner to outer diameters of the myelin sheath (g value) was 0.82, which is close to the value (0.8) for the optic fibers of intact adult cats.

journal_name

Exp Brain Res

authors

Watanabe M,Sawai H,Fukuda Y

doi

10.1007/BF00229107

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

39-43

issue

1

eissn

0014-4819

issn

1432-1106

journal_volume

98

pub_type

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