Radioautographic study of 3H-GABA uptake in the oculomotor nucleus of the cat.

Abstract:

:The uptake of tritiated gamma-aminobutyric acid (3H-GABA) in the oculomotor nucleus of the cat was studied, using light and electron microscopic examination of radioautograms after intracerebral in vivo administration of the amino-acid. A glial uptake by oligodendrocytes was seen together with a neuronal uptake of the tracer in a certain type of axon terminals found in synaptic contact with both dendrites and soma, some of them exhibiting all the ultrastructural features of motoneurons. Previous neurochemical, electrophysiological and immunocytochemical studies indicate that GABA might well be the inhibitory neurotransmitter in the vestibuloocular reflex arc. The present results show that a morphological substrate exists for the presumed postsynaptic GABAergic inhibition of ocular motoneurons, at least in the oculomotor nucleus of the cat.

journal_name

Exp Brain Res

authors

Lanoir J,Soghomonian JJ,Cadenel G

doi

10.1007/BF00239581

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

137-43

issue

1

eissn

0014-4819

issn

1432-1106

journal_volume

48

pub_type

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