Abstract:
:The synRas transgenic mice express constitutively activated Valin12-Harvey Ras in postnatal neocortical pyramidal neurons. This leads to somatodendritic hypertrophy, higher densities of spines and synapses, and an enhancement of synaptic long-term potentiation associated with an increased glutamate receptor-mediated activity. It was less clear how the interneurons respond to these alterations, and this prompted the quantitative assessment of interneuron neurochemistry. Interneurons rarely expressed the transgene, however, several interneuron types displayed a transient somatic hypertrophy. Furthermore, NPY mRNA expression was persistently increased as were the laminar percentages of labeled neurons. The expression of parvalbumin and voltage-gated potassium channels Kv3.1b/3.2 was unchanged. A significant decline of GAD-67, but not GAD-65, mRNA expressing neurons was observed in layer VI in animals older than P60. This suggested that subtle deficits in inhibition and enhanced excitation evoke the interneuronal changes in the synRastransgenic mouse cortex.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Patz S,Colovic C,Wawro S,Lafenetre P,Leske O,Heumann R,Schönfelder S,Tomaschewski J,Räk A,Wahle Pdoi
10.1007/s00221-008-1688-ysubject
Has Abstractpub_date
2009-12-01 00:00:00pages
265-78issue
3-4eissn
0014-4819issn
1432-1106journal_volume
199pub_type
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