Abstract：
:The effects of trans-1-amino-cyclopentyl-1,3-dicarboxylate (trans-ACPD) and of DL-2-amino-3-phosphonopropionic acid (AP3), i.e. selective agonist and antagonist of metabotropic quisqualate receptors respectively, on parallel fibre (PF)-mediated EPSPs of Purkinje cells (PCs) were studied in an in vitro slice preparation. Bath application of 500 microM trans-ACPD in conjunction with PF stimulation at 0.2 or 1 Hz depending on the cell always induced a marked depression of PF-mediated EPSPs, which was fully reversible in most cases after wash-out of this compound. Trans-ACPD also often induced a transient depolarization of PCs which induced calcium spike firing in these cells and which again no longer persisted after wash-out of trans-ACPD. Even in cells which were depolarized by trans-ACPD, the decrease in amplitude of PF-mediated EPSPs started before the appearance of calcium spikes, lasted longer than the transient depolarizing effect of trans-ACPD, and was accompanied by no variation in input resistance of the cells when they were manually clamped at their initial resting potential. Bath application of 600 microM DL-AP3 had no effect on PF-mediated EPSPs or the bioelectrical activities of PCs. Moreover, it did not prevent the effects of trans-ACPD mentioned before. The present results are not consistent with the view that coactivation of ionotropic and metabotropic quisqualate receptors of PCs is sufficient to induce a long-term depression of PF-mediated EPSPs.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Crepel F,Daniel H,Hemart N,Jaillard Ddoi
10.1007/BF00228964subject
Has Abstractpub_date
1991-01-01 00:00:00pages
402-6issue
2eissn
0014-4819issn
1432-1106journal_volume
86pub_type
杂志文章abstract：:Sources of primary afferent depolarization (PAD) of skin afferents in the sural (Sur) nerve and of group-II muscle afferents in the posterior biceps and semitendinosus (PBST) nerve were compared at several sites, about 2 mm apart, within the L7-S2 segments in order to define areas of projection of sacral interneurons ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000429
更新日期：2000-08-01 00:00:00
abstract：:Perhaps the most intriguing disorders of body representation are those that are not due to primary disease of brain tissue. Strange and sometimes painful phantom limb sensations can result from loss of afference to the brain; and Complex Regional Pain Syndrome (CRPS)-the subject of the current report-can follow limb t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2107-8
更新日期：2010-07-01 00:00:00
abstract：:It is a common experience, immediately after the removal of a cast or a splint, to feel motor awkwardness, which is usually attributed to muscular and joint immobilization. However, the same feeling may also be perceived after a brief period of immobilization. We provide evidence that this last effect stems from chang...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3115-7
更新日期：2012-07-01 00:00:00
abstract：:The purpose of this study was to compare the asymmetric gait induced by unilateral spinal cord injury in chicks with asymmetric gaits of other bipeds and quadrupeds. After lateral hemisection of the left thoracic spinal cord, kinetic (ground reaction forces) and kinematic (distance and timing) data were recorded as ch...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050515
更新日期：1998-10-01 00:00:00
abstract：:In situ hybridization was used to study the expression of prepro-neuropeptide Y (NPY), preprosomatostatin (SOM), preprotachykinin (PPT) and preprocholecystokinin (CCK) mRNA in caudate-putamen and frontoparietal cortex of rat brain with unilateral lesion of midbrain dopamine neurons. Neurons expressing NPY and SOM mRNA...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227990
更新日期：1990-01-01 00:00:00
abstract：:The purpose of this study was to identify the functional fields activated in relation to gestural movements. Using functional magnetic resonance imaging (fMRI), we mapped brain activity in ten right-handed, normal volunteers during activation and control tasks. The activation condition consisted of pantomiming tool-us...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002210100777
更新日期：2001-08-01 00:00:00
abstract：:In order to study prehension in a reproducible manner, we trained monkeys to perform a task in which rectangular, spherical, and cylindrical objects were grasped, lifted, held, and lowered in response to visual cues. The animal's hand movements were monitored using digital video, together with simultaneously recorded ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050803
更新日期：1999-08-01 00:00:00
abstract：:Automatic postural responses of leg muscles to the sudden displacement of standing support were investigated under four different conditions of information given to subjects in advance. Results from three groups of subjects were compared: 6 normal subjects, 10 patients with cerebellar disease, and 9 patients with Park...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231777
更新日期：1991-01-01 00:00:00
abstract：:This paper investigates how the efficiency and robustness of a skilled rhythmic task compete against each other in the control of a bimanual movement. Human subjects juggled a puck in 2D through impacts with two metallic arms, requiring rhythmic bimanual actuation. The arms kinematics were only constrained by the posi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1297-9
更新日期：2008-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4461-z
更新日期：2016-02-01 00:00:00
abstract：:Dissociated cell suspensions were prepared from the ventral midbrain of normal mouse foetuses and stereotaxically implanted into the neostriatum of 2-3 months old homozygous weaver mutant mice, which are severely deficient in dopamine. In tests of amphetamine-induced turning behaviour 60 days after grafting, recipient...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228869
更新日期：1990-01-01 00:00:00
abstract：:The dual-task (motor and cognitive) performance of eight older adults (72.0 ± 6.4 years; 5 female; 3 male) was evaluated. Vocal choice reaction times (cognitive task) were measured at standstill as well as during unperturbed and perturbed gait (motor task). The perturbation was administered using customized shoes inst...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4533-0
更新日期：2016-04-01 00:00:00
abstract：:We investigated whether the order of gaze shifts affected spatial and temporal aspects of discrete bimanual pointing movements. Ten male participants concurrently executed bimanual pointing movements as quickly and accurately as possible to left and right lateral targets presented with the same and different amplitude...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1950-y
更新日期：2009-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1530-5
更新日期：2003-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238464
更新日期：1979-06-01 00:00:00
abstract：:The purpose of this study was to investigate the temporal relationship between presaccadic neuronal discharges in the frontal eye fields (FEF) and supplementary eye fields (SEF) and the initiation of saccadic eye movements in macaque. We utilized an analytical technique that could reliably identify periods of neuronal...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241967
更新日期：1995-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239733
更新日期：1978-06-19 00:00:00
abstract：:Single neuronal activities were recorded in the arm/trunk region of the postcentral gyrus in awake Japanese monkeys. A total of 1608 units were isolated from four hemispheres of two animals, and receptive fields (RFs) and submodalities were identified in 1162 units. Deep or skin submodality neurons were dominant in ar...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050574
更新日期：1998-12-01 00:00:00
abstract：:The acquisition of co-ordination between posture and movement was investigated in human subjects performing a load lifting task. Sitting subjects held their left (postural) forearm in a horizontal position while supporting a 1 kg load via an electromagnet. Perturbation of the postural forearm position consisted of the...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00274991
更新日期：1989-01-01 00:00:00
abstract：:For a long time, a controversy has been proposed that whether the process of theory of mind is a result of domain-specific or domain-general changes (Wellman in The handbook of childhood cognitive development. Blackwell Publication, New Jersey, 2011). This event-related potential study explored the neural time course ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3661-7
更新日期：2013-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF02423506
更新日期：1990-01-01 00:00:00
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更新日期：2007-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
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更新日期：2002-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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更新日期：2007-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235479
更新日期：1984-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235671
更新日期：1979-01-15 00:00:00
abstract：:The presence of after-effects in adaptation tasks implies that an existing internal model has been updated. Previously, we showed that although observers adapted to a visuomotor perturbation, they did not show after-effects. In this experiment, we tested 2 further observer groups and an actor group. Observers were now...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2996-1
更新日期：2012-04-01 00:00:00
abstract：:Both vestibular and neck proprioceptive inputs contribute towards maintaining a walking trajectory. We investigated how aging alters neck proprioceptive and vestibular interaction for preserving equilibrium and spatial orientation during locomotion. Young and healthy elderly were exposed to two sensory manipulations a...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-005-0182-z
更新日期：2005-12-01 00:00:00
