Abstract：
:In situ hybridization was used to study the expression of prepro-neuropeptide Y (NPY), preprosomatostatin (SOM), preprotachykinin (PPT) and preprocholecystokinin (CCK) mRNA in caudate-putamen and frontoparietal cortex of rat brain with unilateral lesion of midbrain dopamine neurons. Neurons expressing NPY and SOM mRNA showed a similar distribution and the expression of both NPY and SOM appears to be regulated by dopamine in a similar fashion. Following a dopamine deafferentation, the numerical density of both NPY and SOM mRNA producing neurons almost doubled in the lesioned caudate-putamen with no change in the average grain density over positive neurons. Hence, in the intact caudate-putamen dopamine appears to suppress expression of these two neuropeptide genes leading to an activation of both NPY and SOM mRNA expression in many non- or low-expressing neurons when the level of dopamine is decreased. In the fronto-parietal cortex, on the other hand, dopamine appears to stimulate NPY and SOM gene expression. Thus, in the absence of dopamine about half of the NPY positive neurons disappeared. However, for SOM the number of positive neurons did not change, but rather most positive neurons appeared to have down-regulated their SOM mRNA expression. No evidence was found for a change in CCK mRNA expression by the dopamine deafferentation, while PPT mRNA expression decreased in the deafferented caudate-putamen. Consequently, dopamine exerts dissimilar effects on the expression of different neuropeptide genes, that in turn do not respond in the same way in different brain regions.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Lindefors N,Brené S,Herrera-Marschitz M,Persson Hdoi
10.1007/BF00227990subject
Has Abstractpub_date
1990-01-01 00:00:00pages
489-500issue
3eissn
0014-4819issn
1432-1106journal_volume
80pub_type
杂志文章abstract：:In four monkeys with long-standing partial ablation of the striate cortex pellets of horseradish peroxidase were placed in either the striate cortex immediately adjacent to the ablation, or in the extrastriate cortex of the ventral prelunate gyrus, i.e. in visual area V4. We examined the dorsal lateral geniculate nucl...
journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1978-05-12 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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更新日期：1980-01-01 00:00:00
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更新日期：2003-09-01 00:00:00
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更新日期：2009-05-01 00:00:00
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更新日期：2010-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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更新日期：2005-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2462-5
更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00230292
更新日期：1993-01-01 00:00:00
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更新日期：2007-01-01 00:00:00
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更新日期：2000-11-01 00:00:00
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更新日期：2005-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2002-10-01 00:00:00
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journal_title：Experimental brain research
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更新日期：2001-07-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1997-06-01 00:00:00
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journal_title：Experimental brain research
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更新日期：2000-11-01 00:00:00
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更新日期：2003-03-01 00:00:00
