Abstract:
:We investigated the effects of intracerebroventricular (i.c.v.) pertussis toxin upon the sensitivity of supraoptic oxytocin neurones to intravenous morphine (1-5000 micrograms/kg) in urethane-anaesthetized rats. The maximal inhibitory capacity of morphine was diminished by prior administration of pertussis toxin. Some cells were tested with both morphine and with the kappa-opioid agonist U50,488 (1-5000 micrograms/kg): U50,488-induced inhibition of firing rate was apparently unimpaired by pertussis toxin pre-treatment. The opioid inhibition of firing rate seen in the absence of and after pertussis toxin pre-treatment was naloxone-reversible. Thus a pertussis toxin-sensitive G protein may mediate the inhibitory action of morphine upon supraoptic putative oxytocin neurones or inputs to them.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Pumford KM,Leng G,Russell JAdoi
10.1007/BF00230292subject
Has Abstractpub_date
1993-01-01 00:00:00pages
247-51issue
2eissn
0014-4819issn
1432-1106journal_volume
94pub_type
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