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Timing of conditioned eyeblink responses is impaired in children with attention-deficit/hyperactivity disorder.

Abstract：

:Structural changes of the cerebellum have been reported in several psychiatric diseases like schizophrenia, autism and attention-deficit/hyperactivity disorder (ADHD). Beside behavioral deficits children with ADHD often show slight motor abnormalities. Cerebellar malfunction may contribute. The cerebellum is a structure essential for motor coordination, various forms of motor learning and timing of motor responses. In the present study, eyeblink conditioning was applied to investigate learning and timing of motor responses both in children with ADHD and children with cerebellar lesions. Acquisition, timing and extinction of conditioned eyeblink responses were investigated in children with ADHD, children with chronic surgical cerebellar lesions and controls using a standard delay paradigm with two different interstimulus intervals. Timing of conditioned eyeblink responses was significantly impaired in children with ADHD in the long interstimulus interval condition. Also in children with cerebellar lesions conditioned responses (CR) tended to occur earlier than in controls. Incidences of CRs were significantly reduced in children with cerebellar lesions and tended to be less in children with ADHD than in controls. Extinction of the CRs was impaired in children with cerebellar lesions in both interstimulus interval conditions and in children with ADHD in the long interstimulus interval condition. Cerebellar malfunction may contribute to disordered eyeblink conditioning in ADHD. However, because CR abnormalities differed between ADHD and cerebellar subjects, dysfunction of non-cerebellar structures cannot be excluded.

journal_name

Exp Brain Res

journal_title

Experimental brain research

authors

Frings M,Gaertner K,Buderath P,Gerwig M,Christiansen H,Schoch B,Gizewski ER,Hebebrand J,Timmann D

doi

10.1007/s00221-009-2020-1

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

167-76

issue

2

eissn

0014-4819

issn

1432-1106

journal_volume

201

pub_type

杂志文章

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