Abstract:
:We describe a new form of gamma-aminobutyric acid (GABA) -mediated regulation of the inactivation and of the recovery from inactivation of the L-type Ca2+ current (I(Ca)) in crayfish muscle. GABA (1 mM) was applied during a 2-min period and the peak I(Ca) was measured using two-electrode voltage-clamp recordings 30 min after returning to the control solution. Prepulse-pulse protocols showed that the GABA-mediated inhibition of I(Ca) decreased (>50%) both with increasing prepulse depolarization and as the delay between prepulse and pulse was reduced. GABA also shifted to depolarized values (>5 mV) the S-shaped plots of the peak I(Ca) evoked by a constant depolarizing pulse as a function of prepulse voltage (i.e., inactivation curves) and accelerated the recovery time from the inactivation evoked by depolarizing prepulses (>35%). The effects outlasted GABA application up to 1 h. The observed changes in inactivation properties may be of functional importance because they indicate that previous depolarization relieves the GABA-induced inhibition of I(Ca), implying that this long-lasting inhibition is under the regulation of the prepulse potential and the subsequent Ca2+ entry.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Castellote JM,Buño Wdoi
10.1007/s002210000445keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
90-5issue
1eissn
0014-4819issn
1432-1106journal_volume
134pub_type
杂志文章abstract::We examined modulation of transmission in short-latency, distal hindlimb cutaneous reflex pathways during fictive locomotion in 19 decerebrate cats. Fictive stepping was produced either by electrical stimulation of the mesencephalic locomotor region (MLR) or by administration of Nialamide and 1-DOPA to acutely spinali...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00250567
更新日期:1989-01-01 00:00:00
abstract::The effects of degrading retinal image velocity information on suppression of the vestibulo-ocular reflex have been assessed through tachistoscopic presentation of target sources in man. Subjects were required to fixate a head-fixed display during exposure to a 0.5 Hz sinusoidal angular oscillation of the head at +/- ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239187
更新日期:1983-01-01 00:00:00
abstract::We explored changes in the cyclical two-finger force performance task caused by turning visual feedback off performed either by the index and middle fingers of the dominant hand or by two index fingers of two persons. Based on an earlier study, we expected drifts in finger force amplitude and midpoint without a drift ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5179-5
更新日期:2018-03-01 00:00:00
abstract::The principal goal of our study is to gain an insight into the representation of peripersonal space. Two different experiments were conducted in this study. In the first experiment, subjects were asked to represent principal anatomical reference planes by drawing ellipses in the sagittal, frontal and horizontal planes...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0121-z
更新日期:2006-02-01 00:00:00
abstract::The fluorescent double-labeling technique has been used to determine whether the corticopontine and the corticotectal fibers in the cat are derived from two different sets of neurons or whether they are derived from branching neurons which distribute collaterals to the pontine grey and the colliculi. After unilateral ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00269447
更新日期:1987-01-01 00:00:00
abstract::The purpose of this study was to investigate the temporal relationship between presaccadic neuronal discharges in the frontal eye fields (FEF) and supplementary eye fields (SEF) and the initiation of saccadic eye movements in macaque. We utilized an analytical technique that could reliably identify periods of neuronal...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241967
更新日期:1995-01-01 00:00:00
abstract::The purpose of this study was to investigate the role of cutaneous feedback in the agonist-antagonist co-activation mechanism during maximum voluntary force (MVF) production by the fingers. Seventeen healthy male subjects (age: 23.8 ± 1.0 years) were asked to press with maximal effort at their fingertips. Finger force...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3601-6
更新日期:2013-08-01 00:00:00
abstract::Chronic pain and gait variability in a dual-task situation are both associated with higher risk of falling. Executive functions regulate (dual-task) gait variability. A possible cause explaining why chronic pain increases risk of falling in an everyday dual-task situation might be that pain interferes with executive f...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4039-1
更新日期:2014-11-01 00:00:00
abstract::The synapsins are presynaptic membrane-associated proteins involved in neurotransmitter release. They are differentially expressed in tissues and cells of the central and peripheral nervous system. In vestibular end organs of mammals, synapsin I-like immunoreactivity has been reported in efferent and afferent terminal...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2194-5
更新日期:2005-04-01 00:00:00
abstract::The distributions of the kainate/DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (KA/ AMPA) receptors GluR1 and calcium-activated neutral protease II (calpain II) in the hippocampus of normal and kainate-lesioned rats were studied by immunocytochemistry. There was a reduction in GluR1 immunoreactivity and a s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF02454147
更新日期:1997-01-01 00:00:00
abstract::Spike trains of long duration were recorded from concurrently active pairs of motor units in the human masseter and tibialis anterior muscles. An innovative analysis technique was used to investigate functional coupling between the motoneurons by plotting the discharge frequency of one motor unit with respect to the f...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00228735
更新日期:1996-10-01 00:00:00
abstract::The importance of the caudal ventrolateral medulla (CVLM) in mediating vagal cardiopulmonary (Bezold-Jarisch reflex) reflex activity was studied in urethane-anaesthetized rats. Unilateral electrolytic lesion of the CVLM markedly attenuated Bezold-Jarisch reflex responses (hypotension and bradycardia) elicited by intra...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230698
更新日期:1989-01-01 00:00:00
abstract::Stimulus-response compatibility (SRC) effects are classified depending on the way that the elements of the stimulus and response sets interact, influencing both the speed and accuracy of the motor response. This is particularly important for social stimuli, such as hands. However, the stimuli used in most SRC studies ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4283-z
更新日期:2015-07-01 00:00:00
abstract::During fast, saccadic eye movements visual perception is suppressed. This saccadic suppression prevents erroneous and distracting motion percepts resulting from saccade induced retinal slip. Although saccadic suppression occurs over a substantial time interval around the saccade, there is no "perceptual gap" during sa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0876-5
更新日期:2007-07-01 00:00:00
abstract::Human orientation in novel and familiar environments is a complex skill that can involve numerous different strategies. To date, a comprehensive account of how these strategies interrelate at the behavioural level has not been documented, impeding the development of elaborate systems neuroscience models of spatial ori...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3316-0
更新日期:2013-02-01 00:00:00
abstract::Two versions of the hypothesis that discrete movements are produced by shifts in the system's equilibrium point are considered. The first suggests that shifts are monotonic and end near the peak velocity of movement, and the second presumes that they are nonmonotonic ("N-shaped") and proceed until the end of movement....
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00241503
更新日期:1995-01-01 00:00:00
abstract::Adaptation of motor control to weightlessness was studied during a 7-day spaceflight. The maintenance of control of upright posture was examined during a voluntary raising movement of the arm and during the voluntary raising on tiptoe. In order to evaluate the contribution of visual cues, three types of visual situati...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231132
更新日期:1984-01-01 00:00:00
abstract::Pineal glands were collected from superior cervical ganglionectomized (SCGX) and sham-treated rats at time intervals following surgical manipulation. Pineal noradrenaline (NA) levels were quantitated by a radioisotopic-enzyme technique, or the pineals were examined by histofluorescence or electron microscopic techniqu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238713
更新日期:1978-07-14 00:00:00
abstract::The response characteristics of mechanoreceptive neurons (RA, SA, and PC) innervating the foot pad of cat were determined in the cuneate nucleus. The mechanical stimuli were single sinusoidal pulses of varying frequency (20, 60, 150, and 240 Hz), and vibratory trains of varying frequency (80 and 240 Hz) and duration (...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236027
更新日期:1986-01-01 00:00:00
abstract::To determine if PAG stimulation activates serotonin containing neurons in RM, intracellular techniques were used to identify raphe magnus (RM) cells that are excited by antinociceptive periaqueductal gray (PAG) stimulation in the cat. RM neurons that received a monosynaptic EPSP from PAG shock were intracellularly lab...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00279654
更新日期:1988-01-01 00:00:00
abstract::Grasping using two forelimbs in opposition to one another is evolutionary older than the hand with an opposable thumb (Whishaw and Coles in Behav Brain Res 77:135-148, 1996); yet, the mechanisms for bimanual grasps remain unclear. Similar to unimanual grasping, the localization of matching stable grasp points on an ob...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3643-9
更新日期:2013-10-01 00:00:00
abstract::We explored digit coordination during the acceleration phase of a quick lifting movement of a hand-held horizontal object. We tested three hypotheses related to: (1) the scaling of mechanical variables produced by the hand with changes in the external load, torque, and moment of inertia; (2) changes in the safety marg...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3215-4
更新日期:2012-10-01 00:00:00
abstract::Ageing affects many visual functions. Here, we investigated the effects of ageing on vernier acuity and backward masking using the shine-through paradigm. We divided healthy older adults (>60 years) into two groups depending on whether vernier duration was comparable to younger adults (Older Adults 1) or not (Older Ad...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4314-9
更新日期:2015-08-01 00:00:00
abstract::The present study investigated the effect of auditory feedback on planning and control of two-segment reaching movements and eye-hand coordination. In particular, it was examined whether additional auditory information indicating the progression of the initial reach (i.e., passing the midway and contacting the target)...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5366-4
更新日期:2018-12-01 00:00:00
abstract::Stellate cells within the ventral cochlear nucleus (VCN) are a diverse cell group that have been classified according to their size and morphology. Some of these stellate cell types constitute major projection neurones into the brainstem and directly into the inferior colliculus, while others are implicated in more lo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1602-6
更新日期:2003-12-01 00:00:00
abstract::To investigate how the sensorimotor systems of eye and hand use position, velocity, and timing information of moving targets, we conducted a series of three experiments. Subjects performed combined eye-hand catch-up movements toward visual targets that moved with step-ramp-like velocity profiles. Visual feedback of th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2028-5
更新日期:2005-01-01 00:00:00
abstract::Primary somatosensory cortex (S1) is known to rapidly adapt to task demands and to intermodal information (e.g. from vision). Here, we show that also intramodal information (i.e. posture) can affect tactile attentional selection processes and the intermodal effects of vision on those processes at S1 stages of processi...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-012-3171-z
更新日期:2012-09-01 00:00:00
abstract::The purpose of this study is to analyze the coordination patterns of the elevation angles of lower limb segments following the onset of unsupported walking in children and to look for the existence of a planar covariation rule as previously described in adult human locomotion. The kinematic patterns of locomotion were...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s002210000663
更新日期:2001-04-01 00:00:00
abstract::The uptake of L-glutamate was studied in astrocytes cultured from different brain areas of newborn rats as well as in two different cultures of neurons obtained from mouse brain. Both astrocytes and neurons exhibited high-affinity glutamate uptake with Km values ranging from 34 microM to 82 microM. Vmax values for ast...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239385
更新日期:1982-01-01 00:00:00
abstract::The saccadic system has been traditionally regarded as two-dimensional (horizontal, vertical) and basically conjugate in the two eyes. However, saccades to disparate targets (e.g., targets in real three-dimensional space that are located in different directions and at different distances) are naturally disconjugate. W...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s002210050529
更新日期:1998-10-01 00:00:00