Abstract：
:The fate of monoclonal anti-vasopressin antibodies (VP-MAbs) injected in vivo into the paraventricular nucleus (PVN) of the rat brain was studied by immunocytochemistry. Depending on the post survival time, VP-MAbs contained in an ascites fluid were stained at different levels of the VP neurons: the cytoplasm of the PVN neurons, the fibres of the median eminence and the granular layer of the Gyrus Dentatus. The identification of endogenous peptides synthesized by PVN neurons showed that the VP-MAbs uptake was specific: it did not appear either in the oxytocinergic neurons or in the non immunoreactive neurons of the Brattleboro rat brain, this rat being genetically incapable of synthesizing central VP. Conversely, VP-MAbs only penetrated into the VP neurons: ascites fluid containing monoclonal antibodies prepared against bovine thyroglobulin (the carrier conjugated to VP in our immunizations) was neither stained in magnocellular neurons nor carried in nerve fibres. The neuronal uptake and transport of VP-MAbs occurred in vivo: they were totally inhibited by heating of the ascites fluid at 56 degrees C for 30 min; this treatment did not alter the VP-MAbs themselves but probably destroyed some thermic sensitive component essential to the macromolecule internalization. The biological effects of antibodies injected in vivo have been reported. The results described here suggest that some specific antibodies passively transferred into the brain could act directly on the peptide synthesis recognized by the antibodies.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Burlet AJ,Leon-Henri BP,Robert FR,Arahmani A,Fernette BM,Burlet CRdoi
10.1007/BF00235986subject
Has Abstractpub_date
1987-01-01 00:00:00pages
629-38issue
3eissn
0014-4819issn
1432-1106journal_volume
65pub_type
杂志文章abstract：:Previous work has indicated that people do not use their judgment of a target's speed to determine where to hit it. Instead, they use their judgment of the target's changing position and an expected speed (based on the speed of previous targets). In the present study we investigate whether people also ignore the targe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1556-8
更新日期：2003-10-01 00:00:00
abstract：:Filial imprinting was originally proposed to be an irreversible process by which a young animal forms a preference for an object experienced early in life. The present study examined the effects of experience after imprinting on the stability of preferences of domestic chicks (Gallus gallus domesticus) for an imprinti...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2769-x
更新日期：2011-08-01 00:00:00
abstract：:The purpose of this study was to establish whether visual motion parallax participates in the control of postural sway. Body sway was measured in ten normal subjects by photoelectric recordings of head movements and by force-plate posturography. Subjects viewed a visual display ("background"), which briefly moved (2 s...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF02450322
更新日期：1997-02-01 00:00:00
abstract：:The time of maximal occurrence of pyknotic nuclei in the retinal ganglion cell layer of postnatal pearl mutant mice is earlier than that in normal mice (Linden and Pinto 1985). Both ganglion and displaced amacrine cells and glia populate the ganglion cell layer. Thus, in order to show that ganglion cells themselves ar...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231258
更新日期：1990-01-01 00:00:00
abstract：:Stimulus-response compatibility (SRC) effects are classified depending on the way that the elements of the stimulus and response sets interact, influencing both the speed and accuracy of the motor response. This is particularly important for social stimuli, such as hands. However, the stimuli used in most SRC studies ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4283-z
更新日期：2015-07-01 00:00:00
abstract：:The primary objective of this study was to explore why preischemic hypoglycemia, which restricts tissue acidosis during the ischemic insult, does not ameliorate cell damage incurred as a result of transient ischemia. The question arose whether hypoglycemia (plasma glucose concentration 2-3 mM) delays resumption of ext...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00233036
更新日期：1995-01-01 00:00:00
abstract：:Neurons responding to deep or cutaneous stimuli are situated in different parts of the ventrobasal complex. Within the cutaneous region elongated clusters of cells with common place and modality properties project to single columns in the somatic sensory cortex. The present study sought to determine to what extent sin...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238583
更新日期：1983-01-01 00:00:00
abstract：:Coordination is often observed as body parts moving together. However, when producing force with multiple fingers, the optimal coordination is not to produce similar forces with each finger, but rather for each finger to correct mistakes of other fingers. In this study, we aim to determine whether and how this skill d...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5093-2
更新日期：2017-12-01 00:00:00
abstract：:In a previous study, we assessed the synchronous neural interactions (SNI) in a developing neural network in brain cultures on multielectrode arrays (Christopoulos et al. in J Neural Eng 9:046008, 2012). Here, we report on the effects of apolipoprotein E4 (apoE4) on these neural interactions. We carried out six experi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4270-4
更新日期：2015-06-01 00:00:00
abstract：:Traditional approaches to research on bimanual coordination focus on sensorimotor interference, motor programming, and effects of perception and feedback guidance; surprisingly, little is known about high-level conceptual constraints that might unify separate movements into coordinated actions. We investigated two pos...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2365-5
更新日期：2010-08-01 00:00:00
abstract：:In classic conditioning, the interstimulus interval (ISI) between the conditioned (CS) and unconditioned (US) stimulus is a critical parameter. The aim of the present experiment was to assess whether, during conditioning, modification of the CS-US interval could reliably produce changes in the functional properties of...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002219900290
更新日期：2000-06-01 00:00:00
abstract：:Using a special tetrazolium salt technique, a striking correlation was observed between Na+ concentration of the incubation medium and the formation of formazan catalyzed by glutamate dehydrogenase (GDH) in glutamatergic neuropil areas of the hippocampal formation, cerebellum, and other brain regions. Na+ concentratio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236047
更新日期：1986-01-01 00:00:00
abstract：:Antisaccades have not only longer latencies but also lower peak velocities than prosaccades. It is not known whether these latency and velocity differences are related. Studies of non-human primates suggest that prosaccade peak velocity declines as latency from target appearance increases. We examined whether a simila...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1940-z
更新日期：2004-11-01 00:00:00
abstract：:In the thalamic reticular nucleus (TR) of the rat a cluster of neurons has been located which receives auditory inputs and acts as a source of inhibition for relay neurons of the medial geniculate nucleus (MG). These TR neurons (auditory thalamic reticular neurons; A-TR neurons) showed a repetitive burst of grouped di...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238784
更新日期：1983-01-01 00:00:00
abstract：:Ball-racket interactions were investigated in a task where participants propelled a ball rhythmically into the air. The study contrasted two ball-racket conditions: (1) an elastic impact where the ball was able to rebound due to the elasticity of the colliding objects and participants bounced the ball, and (2) a non-e...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1331-2
更新日期：2003-03-01 00:00:00
abstract：:It has recently been suggested that time perception and motor timing are influenced by the presence of biological movements and animacy in the visual scene. Here, we investigated the interactions among timing, speed and animacy in two experiments. In Experiment 1, observers had to press a button in synchrony with the ...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-012-3338-7
更新日期：2013-02-01 00:00:00
abstract：:Human gait is a complex process in the central nervous system that results from the integrity of various mechanisms, including different cortical and subcortical structures. In the present study, we investigated cortical activity during lower limb movement using EEG. Assisted by a dynamic tilt table, all subjects perf...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2223-5
更新日期：2010-05-01 00:00:00
abstract：:Familiarity with the visual environment affects our expectations about the objects in a scene, aiding in recognition and interaction. Here we tested whether the familiarity with the specific trajectory followed by a moving target facilitates the interpretation of the effects of underlying physical forces. Participants...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4050-6
更新日期：2014-12-01 00:00:00
abstract：:Previous studies have found that attention is oriented in the direction of other people's gaze suggesting that gaze perception is related to the mechanisms of joint attention. However, the role of the perception of gaze direction on joint attention has been challenged. We investigated the effects of disrupting gaze pe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1706-8
更新日期：2009-04-01 00:00:00
abstract：:The pattern of gamma-efferent innervation of the muscle spindle was investigated in the peroneus tertius muscle of the cat. A number of spindle group Ia afferents were isolated and monitored during tetanic stimulation of isolated gamma-axons. The sample was dominated by efferents producing a static fusimotor effect on...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236812
更新日期：1983-01-01 00:00:00
abstract：:Reports of spatial interactions between current and upcoming elements in a movement sequence could be due to intentional planning of a "global" action sequence (i.e., strategic effects), or to unintentional motor planning arising from merely paying attention to upcoming target objects (i.e., interference effects). The...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4511-6
更新日期：2016-04-01 00:00:00
abstract：:We investigated the contributions of lateral intracortical connections to the orientation tuning of area 17 cells using micro-iontophoresis of the inhibitory transmitter gamma-aminobutyric acid (GABA) to inactivate small cortical sites in the vicinity of a recorded cell. GABA was ejected from an array of micropipettes...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228003
更新日期：1990-01-01 00:00:00
abstract：:Saccadic latencies measured in response to a step-wise displacement of the target may be substantially reduced if a gap separates the offset of the initial fixation point and the onset of the peripheral target. According to Fischer and Ramsperger (1984) this paradigm provokes a bimodal latency distribution which consi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229892
更新日期：1992-01-01 00:00:00
abstract：:In goal-oriented locomotion, healthy adults generate highly stereotyped trajectories and a consistent anticipatory head orienting behaviour, both evidence of top-down, open-loop control. The aim of this study is to describe the typical development of anticipatory orienting strategies and trajectory formation. Our hypo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3495-3
更新日期：2013-05-01 00:00:00
abstract：:Recently, it has been reported that grasping with the left hand is more vulnerable to visual size illusions than grasping with the right hand. The present study investigated whether this increased sensitivity of the left hand for visual context extends to reaching. Left- and right-handed participants reached for targe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2214-6
更新日期：2010-05-01 00:00:00
abstract：:We studied 12 patients with Parkinson's disease (PD): 6 with postural instability (Hoehn and Yahr Stage 3) and 6 without (Stage 2 or 2.5), using a quantitative test based on the clinical pull test. Their findings were compared with those for 12 healthy controls. The patients on their usual medications were pulled eith...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05553-8
更新日期：2019-07-01 00:00:00
abstract：:In order to assess the autoinhibitory control of endogenous acetylcholine (ACh) in rat and human neocortex, slices of these tissues were prelabelled with [(3)H]choline, superfused continuously and stimulated electrically using various frequencies in the presence or absence of drugs. The autoinhibitory feedback control...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050858
更新日期：1999-10-01 00:00:00
abstract：:A strong assumption shared by major theoretical approaches to cognition posits that the human cognitive system has a limited capacity for information processing. Evidence supporting this claim comes from the dual-task paradigm in which one cognitive system has to process two tasks simultaneously. In this study, we exa...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2703-2
更新日期：2011-06-01 00:00:00
abstract：:The genesis of the cuneothalamic neurons (CTNs) in the rat cuneate nucleus was determined by a double-labeling method using 5'-bromodeoxyuridine (BrdU), the thymidine analogue, and Fluoro-Gold (FG), a retrograde fluorescent tracer. BrdU-positive cells were observed in the cuneate nucleus in all rats receiving BrdU inj...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-001-0950-3
更新日期：2002-02-01 00:00:00
abstract：:The habenulo-interpeduncular system of the rat constitutes an interesting model to address quantitatively problems related to synaptogenesis and to the interactions between neuronal populations after selective alteration of these elements during development. In the present study this has been achieved by experimentall...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227241
更新日期：1992-01-01 00:00:00
