Empathy for pain-related dorsolateral prefrontal activity is modulated by angry face perception.

Abstract:

:Empathy, i.e., the ability to perceive and share another person's affective state, is associated with activity in a complex neural network, including the anterior insula, the anterior and mid-cingulate cortex, and the lateral prefrontal cortex. Here, we were interested in the question how facial emotions influence the activation of the 'pain network'. In the present study, we used functional magnetic resonance imaging to investigate the neuronal correlates of empathy for pain and its interaction with emotional face recognition in 20 healthy subjects. We identified various brain regions commonly associated with empathy for pain, including the right mid-cingulate cortex, the left anterior insula (AI), and the left dorsolateral prefrontal cortex (dlPFC), with an increased neuronal response in the left dlPFC after the presentation of angry faces. Furthermore, a negative correlation between psychological measures of alexithymia and empathy for pain-related brain activity was observed in the left AI. The dlPFC is an important brain region involved in cognitive reappraisal or in 'top-down' control of the limbic system. Our findings could therefore reflect a regulatory response associated with distancing from negatively valenced stimuli. Moreover, our results underline the involvement of the AI in empathy for pain responses and their relationship to alexithymia.

journal_name

Exp Brain Res

authors

Enzi B,Amirie S,Brüne M

doi

10.1007/s00221-016-4731-4

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

3335-3345

issue

11

eissn

0014-4819

issn

1432-1106

pii

10.1007/s00221-016-4731-4

journal_volume

234

pub_type

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