Abstract:
:Schizophrenia patients show impaired saccadic response switching, pointing to action control deficits at the level of response selection. Previous studies on healthy subjects suggested that response switch effects might decrease if the prior response is longer ago, reflecting a slow dissipation of the response program persisting from the previous trial. The present study aimed at directly investigating whether response switch effects in schizophrenia patients and healthy subjects depend on the inter-response interval (IRI). Effects of response switching on pro- and antisaccade performance were analyzed in 19 schizophrenia patients and 19 healthy controls at 3 different IRIs (2,500, 3,000, 4,000 ms). Response switch effects of healthy subjects did not vary with the IRI, suggesting that the previous response program persists as long as no contrary response program is activated. In schizophrenia, response switch deficits were replicated at an IRI of 3,000 ms, whereas at IRIs of 2,500 and 4,000 ms, effects of response switching did not significantly differ from healthy subjects. This might suggest that there is a specific IRI range particularly sensitive to response switch deficits in schizophrenia. However, effects of response switching at different IRIs remain to be consolidated.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Franke C,Reuter B,Breddin A,Kathmann Ndoi
10.1007/s00221-009-1871-9subject
Has Abstractpub_date
2009-07-01 00:00:00pages
429-38issue
3eissn
0014-4819issn
1432-1106journal_volume
196pub_type
杂志文章abstract::While diverging efficacy and inter-individual response variability have repeatedly been reported for paired-associative stimulation (PAS), approaches to overcome these issues are yet lacking. Hence, the aim of the present study was to determine whether response variability could be reduced through the application of a...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-019-05542-x
更新日期:2019-07-01 00:00:00
abstract::Motor-unit activity in m. biceps brachii during isometric flexion contractions has been compared with motor-unit activity during a) slow voluntary movements against constant or increasing preloads and b) flexion contractions while movements were imposed by a torque motor. Recruitment levels and firing frequency behavi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228882
更新日期:1990-01-01 00:00:00
abstract::This study investigated the effects of declined accommodation on reading performance in non-native and native languages. Eighteen native Japanese speakers participated: eight presbyopes and ten non-presbyopes. In the experiment, participants were asked to scan, or sequentially read six-word items presented in two-line...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05588-x
更新日期:2019-09-01 00:00:00
abstract::The companion article (Sholomenko et al. 1991) described the brainstem locomoter regions in the bird where direct intracerebral injection of a number of putative excitatory neurochemicals, including cholinergic agonists, N-methyl-d-aspartate (NMDA) and Substance P, evoke locomotion. Using the same experimental protoco...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231753
更新日期:1991-01-01 00:00:00
abstract::Previous studies have proposed that selecting which hand to use for a reaching task appears to be modulated by a factor described as "task difficulty," defined by either the requirement for spatial precision or movement sequences. However, we previously reported that analysis of the movement costs associated with even...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5423-z
更新日期:2019-02-01 00:00:00
abstract::Vasopressin and oxytocin immunoreactivity (AVP-IR, OT-IR) have been detected in the trigeminal and dorsal root ganglia (TG, DRG) of the rat. We have investigated whether AVP or OT have any neurotransmitter role in these tissues by measuring the effects of the peptides on levels of intracellular second messengers. AVP ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00248795
更新日期:1987-01-01 00:00:00
abstract::Discrimination learning can cause improved and worsened ability to perceive differences. This subsequently affects how stimuli are associated with meanings and behaviors. Here, human listeners were trained with frequency-modulated (FM) tonal sweeps (500-1000 Hz) in a paradigm where one FM rate (8.29 octaves per second...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4866-3
更新日期:2017-04-01 00:00:00
abstract::The aim of this work was to study the neurochemical effects in the brain of GABA-transaminase inhibition by systemic administration of gabaculine (100 mg/kg, i.a.) in the rat. In order to investigate neurotransmitter and related amino-acid compartmentation and metabolism, we have developed an original tool: the coupli...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050802
更新日期:1999-08-01 00:00:00
abstract::In the thalamic ventrobasal complex (VB) of the cat, effects of electrical stimulation of the pyramidal tract (PT) upon activities of 112 relay cells and 18 internuncial cells were examined. Single PT shocks to the cerebral peduncle elicited short-latency discharges in 31 relay cells (mean latency, 1.4 +/- 0.5 msec). ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00234770
更新日期:1975-03-27 00:00:00
abstract::Saccades are known to influence subsequent arm movements. There is less information to suggest that the characteristics of saccades depend on the reaching movements they accompany. To explore this issue, we studied the systematic errors of saccades generated by two adult female Rhesus monkeys (Macaca Mulata), which we...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1427-4
更新日期:2008-08-01 00:00:00
abstract::This study addressed some of the controversial issues surrounding the anticonvulsant effect of phenytoin, and the predictive validity of the guinea-pig kindling model for the screening of anticonvulsant drugs. Following an intraperitoneal injection of either 50 or 75 mg/kg phenytoin, we analysed plasma concentrations ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100852
更新日期:2001-10-01 00:00:00
abstract::We have studied the ultrastructural features of sensory nerve fibers in the ciliary body and the iris and their parent trigeminal ganglion cells, using intra-axonally transported horseradish peroxidase as a tracer. Unmyelinated nerve fibers of ipsilateral trigeminal origin were found in stroma of both the ciliary body...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235287
更新日期:1984-01-01 00:00:00
abstract::Haptic perception is based on the integration of afferent proprioceptive and tactile signals. A further potential source of information during active touch is predicted sensory feedback (PSF) derived from a copy of efferent motor commands that give rise to the exploratory actions. There is substantial evidence that PS...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1996-x
更新日期:2010-01-01 00:00:00
abstract::After injection of S35-methionine into cervical and lumbar dorsal root ganglia in turtle, a primary afferent projection was demonstrated on to the cerebellum. Few, but consistent patches of silver grains were found within the granular layer suggesting mossy fiber terminations. The projection was mainly ipsilateral and...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF01208609
更新日期:1982-01-01 00:00:00
abstract::The brain needs information about the size of the body to control our interactions with the environment. No receptor signals this information directly; the brain must determine body size from multiple sensory inputs and then store this information. This process is poorly understood, but somatosensory information is th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4249-1
更新日期:2015-06-01 00:00:00
abstract::Multichannel surface EMG recordings of a multiheaded skeletal muscle during cyclic locomotion combined with cineradiography were analysed in a chronic experiment. The resulting detailed two-dimensional activation pattern from the long and lateral triceps brachii heads of the rat during treadmill locomotion were combin...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100685
更新日期:2001-05-01 00:00:00
abstract::Successfully picking up and handling objects requires taking into account their physical properties (e.g., material) and position relative to the body. Such features are often inferred by sight, but it remains unclear to what extent observers vary their actions depending on the perceived properties. To investigate thi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4631-7
更新日期:2016-08-01 00:00:00
abstract::It has been repeatedly shown that precise finger force control declines with age. The tasks and evaluation parameters used to reveal age-related differences vary between studies. In order to examine effects of task characteristics, young adults (18-25 years) and late middle-aged adults (55-65 years) performed precisio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3292-4
更新日期:2013-01-01 00:00:00
abstract::In this study we examined the performance of human subjects in three oculomotor tasks: a visually guided saccade task (VST), a simple antisaccade task (SAT) and a mirror antisaccade task (MAT). The stimulus presentation was identical for all three tasks, and the differentiation of the tasks was based on the instructio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0462-2
更新日期:2006-09-01 00:00:00
abstract::Intracellular recording techniques were used to test for cross-modality and topographic convergence among inputs to area 3a of cerebral cortex. Recordings were made within the projection area of group I afferent fibers of the deep radial nerve in barbiturate-anesthetized cats. Epsps were evoked in 90% of neurons (81/9...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236532
更新日期:1985-01-01 00:00:00
abstract::Reaching to a veridical target permits an egocentric spatial code (i.e., absolute limb and target position) to effect fast and effective online trajectory corrections supported via the visuomotor networks of the dorsal visual pathway. In contrast, a response entailing decoupled spatial relations between stimulus and r...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5205-7
更新日期:2018-04-01 00:00:00
abstract::Percutaneous electrical stimulation of the motor point of the first dorsal interosseous muscle (FDI) was used to produce a non-painful contraction of the FDI muscle that caused index finger abduction movement but no radiating cutaneous paraesthesias or sharp sensations localized to joints. Pairs of stimuli separated b...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2353-3
更新日期:2005-10-01 00:00:00
abstract::We tested the hypothesis that frontal eye field (FEF) visual activity integrates visual information with a template of a target by examining whether a target that is not present in a search display influences the target selection in FEF. Neural activity was recorded in FEF of macaque monkeys performing visual search f...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1461-1
更新日期:2003-08-01 00:00:00
abstract::It is known that TMS can induce blinking, but it is unknown to what extent and at what time TMS-induced blinking can cover the pupil. We applied single-pulse TMS with a leftward and rightward monophasic current through a round coil over the occipital pole in 8 healthy subjects, using high-speed video to monitor left o...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2626-y
更新日期:2011-04-01 00:00:00
abstract::Several studies have shown that people can catch a ball even if it is visible only during part of its flight. Here, we examine how well they can do so. We measured the movements of a ball and of the hands of both the thrower and the catcher during one-handed underarm throwing and catching. The catcher's sight was occl...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2421-1
更新日期:2010-10-01 00:00:00
abstract::Eight 10-year-old children manifesting movement co-ordination problems (MCP), as assessed by the Movement Assessment Battery for Children (MABC), and a matched control group of eight children of a similar age without such problems, were required to carry out a laboratory ball-catching task. The task was constrained in...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1193-7
更新日期:2002-11-01 00:00:00
abstract::Transcranial direct current stimulation (TDCS) is a non-invasive form of brain stimulation applied via a weak electrical current passed between electrodes on the scalp. In recent studies, TDCS has been shown to improve learning when applied to the prefrontal cortex (e.g., Kincses et al. in Neuropsychologia 42:113-117,...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2764-2
更新日期:2011-08-01 00:00:00
abstract::Modern tools in technological environments are often characterized by a spatial separation of hand actions (operating a remote control) and their intended action effects (displayed movements of an unmanned vehicle, a robot, or an avatar on a screen). Often non-corresponding proximal and distal movement effects put hig...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3018-7
更新日期:2012-04-01 00:00:00
abstract::Saccadic accuracy, measured as the ratio of the size of a saccade to the size of the target step that elicits it, i.e., saccade gain, can be altered by jumping the target surreptitiously during the targeting saccade. The gain change produced by this paradigm does not generalize or transfer to saccades of all sizes. In...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002219900220
更新日期:2000-01-01 00:00:00
abstract::We examined the coordination of multi-digit grasping forces as they developed during object grasping and lifting. Ten subjects with Parkinson's disease (PD; OFF and ON medication) and ten healthy age-matched control subjects lifted a manipulandum that measured normal forces at each digit and the manipulandum's positio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1129-3
更新日期:2008-02-01 00:00:00