Abstract:
:Vasopressin and oxytocin immunoreactivity (AVP-IR, OT-IR) have been detected in the trigeminal and dorsal root ganglia (TG, DRG) of the rat. We have investigated whether AVP or OT have any neurotransmitter role in these tissues by measuring the effects of the peptides on levels of intracellular second messengers. AVP and OT at concentrations up to 3 x 10(-6) M have no effect on the accumulation of cAMP. However, in tissue prelabelled with 3H-inositol, and in the presence of 10 mM Li+, AVP and OT cause an increase in the accumulation of inositol phosphates (IP), in a dose-dependent manner. AVP causes a maximum stimulation of 1.7 fold of control in TG, (p less than 0.01) and of 2.5 fold in DRG (p less than 0.01) at a concentration of 3 x 10(-7) M. OT causes a maximum stimulation of 1.3 fold of control in TG, (p less than 0.01), and of 1.75 fold of control in DRG, at a concentration of 3 x 10(-6) M. The stimulation of IP turnover by AVP in both tissues is inhibited by the specific V1-antagonist, (CH2)5Tyr(Me)AVP, at a concentration of 2 x 10(-5) M. The V2-agonist, DDAVP, has no effect on IP accumulation in either tissue at concentrations up to 3 x 10(-6) M. The response to exogenous AVP is still present in ganglia incubated in media without added CaCl2. We conclude that the rat TG and DRG contain receptors for AVP, and that these receptors have characteristics associated with the V1 subtype.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Horn AM,Lightman SLdoi
10.1007/BF00248795subject
Has Abstractpub_date
1987-01-01 00:00:00pages
299-304issue
2eissn
0014-4819issn
1432-1106journal_volume
68pub_type
杂志文章abstract::Our previous study showed an increase in total cholesterol level of the hippocampus after kainate-induced injury, but whether this is further metabolized to neurosteroids is not known. The first step in neurosteroid biosynthesis is the conversion of cholesterol to pregnenolone by the enzyme cytochrome P450 side chain ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1209-4
更新日期:2008-03-01 00:00:00
abstract::Stimulation of cutaneous foot afferents has been shown to evoke a facilitation of the tibialis anterior (TA) EMG-activity at a latency of 70-95 ms in the early and middle swing phase of human walking. The present study investigated the underlying mechanism for this facilitation. In those subjects in whom it was possib...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050600
更新日期:1999-01-01 00:00:00
abstract::We applied vibration at various rates to the biceps tendon of a passive, restrained arm in normal human subjects and measured its effect on the perception of forearm position and the perception of forearm velocity. The disturbances of limb position perception and limb velocity perception depended on the vibration rate...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00269450
更新日期:1987-01-01 00:00:00
abstract::Our perception of the vertical depends on allocentric information about the visual surrounds, egocentric information about the own body axis and gravicentric information about the pull of gravity. Previous work has documented that some individuals rely strongly on allocentric information, while others do not, and the ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4526-z
更新日期:2016-04-01 00:00:00
abstract::We measured the amount of information transmitted by the direction of two-dimensional (2-D) arm movements of human subjects, and by neuronal populations in the motor cortex and area 5 of monkeys. We also compared the information transmitted by a motor cortical population when the predictability of the direction of mov...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247577
更新日期:1988-01-01 00:00:00
abstract::Sinusoidal translation while rotating at constant angular velocity about a vertical axis (translation while rotating, TWR) produces centripetal and translational accelerations along the direction of translation and an orthogonal Coriolis acceleration due to the translation in the rotating frame. Thus, a Coriolis accel...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2178-5
更新日期:2005-06-01 00:00:00
abstract::The parietal lobes contribute to body-space representation. The present work aims at characterizing the functional role of the inferior parietal lobe in body-space representation and at studying the different roles of the angular gyrus in the right and left hemisphere. We conducted three separate transcranial direct c...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3538-9
更新日期:2013-07-01 00:00:00
abstract::The arm movement control system often relies on visual feedback to drive motor adaptation and to help specify desired trajectories. Here we studied whether kinematic errors that were indicated with auditory feedback could be used to control reaching in a way comparable with when vision was available. We randomized twe...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-012-3144-2
更新日期:2012-08-01 00:00:00
abstract::It is generally accepted that transferrin receptor is located in the endothelial cells of the brain, but its existence in other brain cell types is less established. In this study, a [(125)I]transferrin binding assay was used to determine whether there is transferrin receptor on the membrane of cultured rat cortical a...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050916
更新日期:1999-12-01 00:00:00
abstract::Schizophrenia patients show impaired saccadic response switching, pointing to action control deficits at the level of response selection. Previous studies on healthy subjects suggested that response switch effects might decrease if the prior response is longer ago, reflecting a slow dissipation of the response program...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1871-9
更新日期:2009-07-01 00:00:00
abstract::The action of delta-aminovaleric acid (AVA) on the muscle relaxant properties of baclofen, a GABAB receptor agonist, was investigated in two experimental models: (1) the pathologically increased muscle tone of the gastrocnemius muscle in spastic mutant Han-Wistar rats and (2) the Hoffmann (H)-reflex recorded from plan...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247610
更新日期:1988-01-01 00:00:00
abstract::Attention to sensory stimulation modulates behavioural responses and cortical activity. Attention to movement can also modulate motor responses. For example, directing attention away from cued movements can increase reaction times. This study used fMRI to determine where in the motor cortex attention to movement modul...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-001-0905-8
更新日期:2002-01-01 00:00:00
abstract::Weight illusions--where one object feels heavier than an identically weighted counterpart--have been the focus of many recent scientific investigations. The most famous of these illusions is the 'size-weight illusion', where a small object feels heavier than an identically weighted, but otherwise similar-looking, larg...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-014-3926-9
更新日期:2014-06-01 00:00:00
abstract::Identifying a stimulus as the target for a goal-directed movement involves inhibiting competing responses. Separable inhibitory interconnections bias local competition to ensure only one stimulus is selected and to alter movement initiation. Behavioural evidence of these inhibitory processes comes from the effects of ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1645-9
更新日期:2009-03-01 00:00:00
abstract::Supervised learning of different postural tasks in patients with lesions of the motor cortex or pyramidal system (poststroke hemiparesis: 20 patients), nigro-striatal system (Parkinson's disease: 33 patients) and cerebellum (spinocerebellar ataxia: 37 patients) was studied. A control group consisted of 13 healthy subj...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0096-9
更新日期:2006-01-01 00:00:00
abstract::The ability to precisely time events is essential for both perception and action. There is evidence that the cerebellum is important for the neural representation of time in a variety of behaviors including time perception, the tapping of specific time intervals, and eye-blink conditioning. It has been difficult to as...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0857-8
更新日期:2007-06-01 00:00:00
abstract::We have investigated the effects of mental set on predictive capabilities using a saccade square-wave tracking paradigm with ten normal subjects, comparing three amplitudes (10, 20, and 40 degrees ) and five inter-stimulus intervals (ISIs) (400, 500, 625, 1000, and 2000 ms). Subjects were instructed simply to "follow ...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s00221-005-2317-7
更新日期:2005-09-01 00:00:00
abstract::Excitatory inputs to neurons in the Forel's field H (FFH) related to visually induced vertical saccades from the ipsilateral superior colliculus (SC) were investigated in chronically prepared alert cats. By stimulation of the deep or intermediate layer of the SC, upward augmenting neurons (ANs) and one long-lead downw...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230857
更新日期:1990-01-01 00:00:00
abstract::Evidence is presented that simple cells in the cat striate cortex (area 17) fail to respond to two dimensional random patterns but respond vigorously to one dimensional patterns with identical power at the preferred orientation of the cell. Further observations suggest that complex cells inhibit simple cells so as to ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238391
更新日期:1981-01-01 00:00:00
abstract::We investigated the role of additional perceptual information (finger touch) and additional mechanical support (hand grasp) on the anticipatory postural adjustments (APAs) associated with fast arm movements performed by standing subjects. The subjects performed fast, unilateral shoulder ante-flexion movements while st...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000492
更新日期:2000-11-01 00:00:00
abstract::Responses of motoneurons supplying muscles of the forelimbs, hindlimbs, back, and neck to stimulation of the medial pontomedullary reticular formation were studied with intracellular recording in cerebellectomized cats under chloralose anesthesia. Stimulation of the midline or of a reticular region consisting of nucle...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238464
更新日期:1979-06-01 00:00:00
abstract::The effect of Coriolis, cross-coupled stimulation on the vestibuloocular reflex and the elicitation of motion sickness depends on background gravitoinertial force level (DiZio et al. 1986, 1987; Graybiel et al. 1977; Lackner and Graybiel 1984, 1986). We have explored whether this response dependency is related to the ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247597
更新日期:1988-01-01 00:00:00
abstract::Two-shock inhibition, a feature of 98 of 100 P cells recorded in the dorsal lateral geniculate nucleus of the normal rat, was not observed in 91 of 140 geniculate cells after an electrolytic lesion had been made in the adjacent visually responsive thalamic reticular nucleus. Nine geniculate cells recorded both before ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237834
更新日期:1985-01-01 00:00:00
abstract::The effect of body posture on the human soleus H-reflex via electrical stimulation of the tibial nerve at the popliteal fossa was studied. All parameters that may influence the reflex were controlled stringently. H-reflexes were elicited in three different body postures while keeping the level of background muscle act...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5182-x
更新日期:2018-03-01 00:00:00
abstract::Functional reorganization in a musician's brain has long been considered strong evidence of experience-dependent neuroplasticity. Highly coordinated bimanual movements require abundant communication between bilateral hemispheres. Interhemispheric inhibition (IHI) is the communication between bilateral primary motor co...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05951-3
更新日期:2020-12-01 00:00:00
abstract::The interaction between pain and the motor system is well-known, with past studies showing that pain can alter corticomotor excitability and have deleterious effects on motor learning. The aim of this study was to better understand the cortical mechanisms underlying the interaction between pain and the motor system. E...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-4880-0
更新日期:2017-04-01 00:00:00
abstract::As a consequence of the fragility of various neural structures, preterm infants born at a low gestation and/or birthweight are at an increased risk of developing motor abnormalities. The lack of a reliable means of assessing motor integrity prevents early therapeutic intervention. In this paper, we propose a new metho...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002219900227
更新日期:2000-04-01 00:00:00
abstract::Pineal glands were collected from superior cervical ganglionectomized (SCGX) and sham-treated rats at time intervals following surgical manipulation. Pineal noradrenaline (NA) levels were quantitated by a radioisotopic-enzyme technique, or the pineals were examined by histofluorescence or electron microscopic techniqu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238713
更新日期:1978-07-14 00:00:00
abstract::For a long time, a controversy has been proposed that whether the process of theory of mind is a result of domain-specific or domain-general changes (Wellman in The handbook of childhood cognitive development. Blackwell Publication, New Jersey, 2011). This event-related potential study explored the neural time course ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3661-7
更新日期:2013-11-01 00:00:00
abstract::Adequate postural control is a prerequisite for daily activities such as reaching for an object. However, knowledge on the relationship between postural adjustments and the quality of reaching movements during human ontogeny is scarce. Therefore we evaluated the development of the relationship between the kinematic fe...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0964-6
更新日期:2007-08-01 00:00:00