Abstract：
:It is generally accepted that transferrin receptor is located in the endothelial cells of the brain, but its existence in other brain cell types is less established. In this study, a [(125)I]transferrin binding assay was used to determine whether there is transferrin receptor on the membrane of cultured rat cortical astrocytes (type 1) in vitro. The results demonstrated that cortical astrocytes (type 1) in suspension attracted [(125)I]transferrin with a saturable and specific binding. Scatchard and Hill plot analysis showed that the dissociation constant (K(D)) of the binding was about 3.5x10(-8) M and the number of receptors was about 7.1x10(4)/cell. The Hill coefficient was 0.99, approaching 1, indicating the absence of cooperativity. The receptor was specific both for rat and human transferrin. The binding of rat [(125)I]transferrin could be competitively and specifically inhibited by unlabeled iron-saturated rat and human transferrin, and no difference was found between interaction of rat or human transferrin with this receptor. The interaction of duck or camel transferrin with this receptor was found to be very weak. This study provides evidence for the presence of transferrin receptor on the plasma membrane of cultured rat brain astrocytes.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Qian ZM,To Y,Tang PL,Feng YMdoi
10.1007/s002210050916keywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
473-6issue
3eissn
0014-4819issn
1432-1106pii
91290473.221journal_volume
129pub_type
杂志文章abstract：:The time of maximal occurrence of pyknotic nuclei in the retinal ganglion cell layer of postnatal pearl mutant mice is earlier than that in normal mice (Linden and Pinto 1985). Both ganglion and displaced amacrine cells and glia populate the ganglion cell layer. Thus, in order to show that ganglion cells themselves ar...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231258
更新日期：1990-01-01 00:00:00
abstract：:Many studies have reported that blind people compensate for their visual deficit by sharpening auditory processes. Here we compare the sensitivity to echo cues between blind and sighted subjects. In the first experiment, the blind subjects were more accurate than the sighted subjects in localizing an object on the bas...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-005-2329-3
更新日期：2005-09-01 00:00:00
abstract：:In the present study, we report the sensitivity of utricular afferents to sinusoidal translational motion in the horizontal plane. The head orientation was altered relative to the direction of translational travel in 30 degrees increments to allow determination of the head orientation that elicited the maximal and min...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1530-5
更新日期：2003-10-01 00:00:00
abstract：:We investigated the effect of musical expertise on sensitivity to asynchrony for drumming point-light displays, which varied in their physical characteristics (Experiment 1) or in their degree of audiovisual congruency (Experiment 2). In Experiment 1, 21 repetitions of three tempos x three accents x nine audiovisual d...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1817-2
更新日期：2009-09-01 00:00:00
abstract：:In order to find out whether human vergence eye movements are influenced by simultaneous hand tracking movements, vergence was studied when sinusoidal (expressed in vergence angles) target movements were tracked. The target motion was externally generated and the target actually moved in depth. Tracking was done by th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00234117
更新日期：1993-01-01 00:00:00
abstract：:Studies exploring reflexive joint attention report that attention is more powerfully captured by interfering social signals (such as others' gaze or hand orientation) than by non-biological directional cues (such as an arrow). However, what remains unknown is whether these effects are mapped in purely spatial or in bo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1900-8
更新日期：2009-08-01 00:00:00
abstract：:The content of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) in motoneurons was studied in four motor pools supplying muscles in the rat hind limb subserving different types of motor activity. The motor pools were identified by retrograde labeling with horseradish peroxidase or fluorophore-conjugated...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227109
更新日期：1993-01-01 00:00:00
abstract：:The effects of repetitive transcranial stimulation (rTMS) on brain activity remain unknown. In healthy subjects, we studied the effects of rTMS on the duration of the cortical silent period (SP). Repetitive stimuli were delivered with a Cadwell High Speed Magnetic Stimulator and a figure-of-eight coil placed over the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050661
更新日期：1999-03-01 00:00:00
abstract：:Standing and walking are very different tasks. It might be reasonable, therefore, to assume that the mechanisms used to maintain the stability of standing and walking should be quite different. However, many studies have shown that postural stability measures can generally predict risk of falls, even though most falls...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0224-6
更新日期：2006-06-01 00:00:00
abstract：:In a previous study, we assessed the synchronous neural interactions (SNI) in a developing neural network in brain cultures on multielectrode arrays (Christopoulos et al. in J Neural Eng 9:046008, 2012). Here, we report on the effects of apolipoprotein E4 (apoE4) on these neural interactions. We carried out six experi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4270-4
更新日期：2015-06-01 00:00:00
abstract：:The contribution of ventral stream information to the variability of movement has been the focus of much attention, and has provided numerous researchers with conflicting results. These results have been obtained through the use of discrete pointing movements, and as such, do not offer any explanation regarding how ve...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0453-3
更新日期：2006-09-01 00:00:00
abstract：:Perceived postural stability has been reported to decrease as sway area increases on firm surfaces. However, changes in perceived stability under increasingly challenging conditions (e.g., removal of sensory inputs) and the relationship with sway area are not well characterized. Moreover, whether perceived stability v...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5458-1
更新日期：2019-03-01 00:00:00
abstract：:We tested the hypothesis that some of the electromyographic (EMG) responses elicited in preactivated forearm muscles by transcranial stimulation of the human motor cortex are produced by activity in a disynaptic corticospinal linkage involving propriospinal-like interneurones with cell bodies in the spinal C3-4 segmen...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229634
更新日期：1996-06-01 00:00:00
abstract：:Human subjects can readily adapt their movement trajectories to different dynamic or visuomotor environments. The focus of the current study was to determine whether subjects could simultaneously adapt to multiple dynamic environments. Subjects ( n=5) drew ellipses continuously for 70 s using a torquable manipulandum ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1260-0
更新日期：2003-01-01 00:00:00
abstract：:The present experiment assessed the locomotor response to a low dose (1 mg/kg) of systemic D-amphetamine in rats with cytotoxic lesions of the retrohippocampus (entorhinal and extra-subicular cortices), compared with vehicle-operated shams and unoperated controls. Under spontaneous and saline conditions, both the sham...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241131
更新日期：1995-01-01 00:00:00
abstract：:Two experiments investigated the contribution of space- and object-based coordinates to previously reported leftward perceptual biases (pseudoneglect) at various locations across visual space. Neurologically intact participants (n = 34 and 27) made luminance discriminations between two left/right mirror-reversed lumin...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2196-3
更新日期：2005-04-01 00:00:00
abstract：:The aim of this study was to investigate the effect of single joint displacement on the pattern of leg muscle electromyographic (EMG) activity during locomotion. For the first time, unilateral rotational hip or knee joint displacements were applied by a driven orthotic device at three phases of swing during locomotion...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1904-3
更新日期：2004-10-01 00:00:00
abstract：:Normally, gamma motoneurones innervate only the intrafusal fibres of muscle spindles. This is a report of sprouting of gamma motoneurones to innervate extrafusal muscle fibres following partial denervation of the soleus muscle of kittens. In eight newborn animals, the L7 ventral root was cut on one side under anaesthe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227250
更新日期：1992-01-01 00:00:00
abstract：:Multichannel surface EMG recordings of a multiheaded skeletal muscle during cyclic locomotion combined with cineradiography were analysed in a chronic experiment. The resulting detailed two-dimensional activation pattern from the long and lateral triceps brachii heads of the rat during treadmill locomotion were combin...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210100685
更新日期：2001-05-01 00:00:00
abstract：:Hand muscle reflexes following muscle stretch and electrical nerve stimulation show a typical pattern consisting of short- and long-latency reflexes. The present investigation was designed to test reflexes following pure cutaneous stimulation. Air puffs were delivered to the palmar tip and the nail bed of the first, s...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00242189
更新日期：1995-01-01 00:00:00
abstract：:The evidence on the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on action restraint on Go/NoGO reaction time (RT) tasks in Parkinson's disease (PD) is inconsistent; with some studies reporting no effect and others finding that STN stimulation interferes with withholding of responses and results in m...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4531-2
更新日期：2016-04-01 00:00:00
abstract：:We have monitored extracellularly individual neurons in the striate cortex of 4-week-old unparalyzed kittens with the aim of changing the ocular dominance of these cells during recording. To do this, we elicited conjugate eye movements using a bipolar stimulating electrode positioned in the internal medullary lamina (...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236575
更新日期：1981-01-01 00:00:00
abstract：:A syntactic and a semantic task were performed by German-speaking healthy subjects and aphasics with lesions in the dominant left hemisphere. In both tasks, pictures of objects were presented that had to be classified by pressing buttons. The classification was into grammatical gender in the syntactic task (masculine ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210100794
更新日期：2001-09-01 00:00:00
abstract：:The authors inadvertently submitted a wrong figure part for publication. Figure 8b should be as follows. ...
journal_title：Experimental brain research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00221-018-5429-6
更新日期：2019-01-01 00:00:00
abstract：:Humans show a gravitational advantage in perception: we are more precise at judging the speed of downwards-moving than upwards-moving objects, indicating that gravitational acceleration is an internalised prior. However, it is unclear whether this gravity prior is based on purely perceptual cues or whether it can inco...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05852-5
更新日期：2020-09-01 00:00:00
abstract：:A medium-latency response (MLR) has been recorded from soleus during stance and walking, and has been attributed to stretch-evoked volleys in group II afferents. The present paper describes a MLR in soleus evoked by stimulating the deep peroneal nerve, documents its characteristics and addresses its likely origin. The...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1621-4
更新日期：2009-02-01 00:00:00
abstract：:We examined the characteristics of postsynaptic potentials (PSPs) produced in antidromically-identified medical gastrocnemius (MG) alpha-motoneurons by electrical stimulation of low threshold (less than 3 x T) distal limb cutaneous afferents in the sural (SUR) nerve in adult cats anesthetized with alpha-chloralose, to...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235772
更新日期：1982-01-01 00:00:00
abstract：:The electrophysiological properties of the two major glial cell types in cultures from the regenerating goldfish optic nerve/tract were studied with patch-clamp techniques. Spindle-shaped cells express myelin proteins. These oligodendrocyte-like cells possess outwardly rectifying currents, do not show glutamate activa...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231855
更新日期：1991-01-01 00:00:00
abstract：:Studies undertaken in head-restrained animals have long implicated the omnipause neurons (OPNs) in the initiation of saccadic eye movements. These inhibitory neurons discharge tonically but cease firing just before and during saccades in all directions. By recording from OPNs in alert behaving head-unrestrained cats, ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00232210
更新日期：1990-01-01 00:00:00
abstract：:The control of eye movements depends in part on subcortical motor centres. Gaze is often directed towards salient visual stimuli of our environment with no conscious voluntary commands. To further understand to what extent preprogrammed eye movements can be triggered subcortically, we carried out a study in normal vol...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0659-4
更新日期：2007-02-01 00:00:00
