Abstract:
:The present experiment assessed the locomotor response to a low dose (1 mg/kg) of systemic D-amphetamine in rats with cytotoxic lesions of the retrohippocampus (entorhinal and extra-subicular cortices), compared with vehicle-operated shams and unoperated controls. Under spontaneous and saline conditions, both the sham and the lesioned animals were more active than unoperated controls, and they did not differ from each other. Systemic D-amphetamine produced increased locomotion in all groups, but this effect was potentiated in animals with retrohippocampal lesions; two control groups did not differ from each other in their response to the drug. The present results are consistent with the suggestion that cell loss within the retrohippocampal region could affect the functional response of nucleus accumbens to amphetamine. The results are discussed in terms of the interaction between the retrohippocampus and nucleus accumbens in the control of mesolimbic dopamine release and the possible implications for schizophrenia.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Yee BK,Feldon J,Rawlins JNdoi
10.1007/BF00241131subject
Has Abstractpub_date
1995-01-01 00:00:00pages
356-64issue
2eissn
0014-4819issn
1432-1106journal_volume
106pub_type
杂志文章abstract::3,4-Methylene-dioxy-N-methylamphetamine (MDMA, 'ecstasy') has a broad spectrum of molecular targets in the brain, among them receptors and transporters of the serotonergic (5-hydroxytryptamine, 5-HT) and noradrenergic systems. Its action on the serotonergic system modulates motor systems in rodents and humans. Althoug...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4095-6
更新日期:2015-01-01 00:00:00
abstract::To address the hypothesis that Parkinson's disease (PD) patients have deficits in controlling acceleration, a drawing task was used in which target size, frequency, and weight of pen were manipulated. In accordance with previous results, it was found that, relative to controls, PD patients produced movements at the re...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1925-z
更新日期:2009-08-01 00:00:00
abstract::Olfaction is unique among the senses in that signals from the peripheral sensory receptors bypass the thalamus on their way to the cortex. The fact that olfactory stimuli are not gated by the thalamus has led some researchers to suggest that people may be unable to selectively direct their attention toward the olfacto...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100713
更新日期:2001-06-01 00:00:00
abstract::A magnetic stimulus applied to the human scalp over the motor cortex causes a short latency contraction of contralateral limb muscles. This is presumed to result from the indirect excitation of corticospinal neurons with monosynaptic connections to motoneurons. The excitability of these cortical neurons can be estimat...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247369
更新日期:1989-01-01 00:00:00
abstract::During fast, saccadic eye movements visual perception is suppressed. This saccadic suppression prevents erroneous and distracting motion percepts resulting from saccade induced retinal slip. Although saccadic suppression occurs over a substantial time interval around the saccade, there is no "perceptual gap" during sa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0876-5
更新日期:2007-07-01 00:00:00
abstract::How do we achieve unitary perception of an object when it touches two parts of the sensory epithelium that are not contiguous? We investigated this problem with a simple psychophysical task, which we then used in an fMRI experiment. Two wooden rods were moved over two digits positioned to be spatially adjacent. The di...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2306-3
更新日期:2010-07-01 00:00:00
abstract::Extracellular recordings were performed from turtle red nucleus neurons to examine their responsiveness to peripheral somatic stimulation and to study differences between rubral sensory and movement-related responses. In pentobarbital sodium-anesthetized or decerebrate turtles, red nucleus neurons could be divided int...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00242899
更新日期:1996-02-01 00:00:00
abstract::To determine if PAG stimulation activates serotonin containing neurons in RM, intracellular techniques were used to identify raphe magnus (RM) cells that are excited by antinociceptive periaqueductal gray (PAG) stimulation in the cat. RM neurons that received a monosynaptic EPSP from PAG shock were intracellularly lab...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00279654
更新日期:1988-01-01 00:00:00
abstract::We investigated the effects of intracerebroventricular (i.c.v.) pertussis toxin upon the sensitivity of supraoptic oxytocin neurones to intravenous morphine (1-5000 micrograms/kg) in urethane-anaesthetized rats. The maximal inhibitory capacity of morphine was diminished by prior administration of pertussis toxin. Some...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230292
更新日期:1993-01-01 00:00:00
abstract::This study compared the mechanisms of adaptation to stable and unstable dynamics from the perspective of changes in joint mechanics. Subjects were instructed to make point to point movements in force fields generated by a robotic manipulandum which interacted with the arm in either a stable or an unstable manner. Afte...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s00221-003-1443-3
更新日期:2003-07-01 00:00:00
abstract::The objective of this study was to define cortical and subcortical structures activated during both active and passive movements of the ankle, which have a fundamental role in the physiology of locomotion, to improve our understanding of brain sensorimotor integration. Sixteen healthy subjects, all right-foot dominant...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2335-5
更新日期:2005-09-01 00:00:00
abstract::In anesthetized and paralyzed cats, the normal alignment of the visual axes is disturbed by paralysis of the eye muscles. Thus, the separation between paired receptive fields of binocular cells in visual cortex is increased (paralysis squint). This increased separation is normally tolerated by the majority of visuocor...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00249802
更新日期:1987-01-01 00:00:00
abstract::The control of eye movements depends in part on subcortical motor centres. Gaze is often directed towards salient visual stimuli of our environment with no conscious voluntary commands. To further understand to what extent preprogrammed eye movements can be triggered subcortically, we carried out a study in normal vol...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0659-4
更新日期:2007-02-01 00:00:00
abstract::Parkinson's disease (PD) is a multifactorial disease with a complex etiology that results from genetic risk factors, environmental exposures and most likely a combination of both. Rodent models of parkinsonism aim to reproduce key pathogenic features of the syndrome including movement disorder induced by the progressi...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-006-0461-3
更新日期:2006-08-01 00:00:00
abstract::Following large injections of horseradish peroxidase - wheat germ agglutinin in the pontine nuclei, corticopontine neurons in areas 18 and 19 were quantitatively mapped and flat maps showing the distribution of retrogradely labeled cells were constructed. The areal borders were defined either cyto- and myeloarchitecto...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237845
更新日期:1985-01-01 00:00:00
abstract::There are a number of studies concerning difference of postural control following left or right hemisphere lesions. Few studies, however, compare the role of the right and left hemisphere in learning new postural tasks. This study aimed to address this question. Twenty patients with hemiparesis after ischemic stroke i...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-2091-z
更新日期:2010-04-01 00:00:00
abstract::The latency of eye movements is influenced by the fixation task; when the fixation stimulus is switched off before the target presentation (gap paradigm) the latency becomes short and express movements occur. In contrast, when the fixation stimulus remains on when the target appears (overlap paradigm), eye movement la...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2214-0
更新日期:2005-07-01 00:00:00
abstract::This study examined c-fos protein expression in the brain and spinal cord of rats following permanent occlusion of the middle cerebral artery (MCA) above the rhinal fissure. At 1 h after right-sided MCA occlusion, Fos-like immunoreactivity (Fos-LI) was detected in neurons not only in the ipsilateral cerebral cortex bu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/pl00005672
更新日期:1997-06-01 00:00:00
abstract::The efferent subcortical connections of the dorsomedial cortical visual area (DM) in the owl monkey were determined by tracing degenerating axons following lesions or by tracing axonal pathways following injection of radioactively labeled proline. Areas of termination included structures which are known to receive inp...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238705
更新日期:1978-07-14 00:00:00
abstract::Quick detection of changes in the sensory environment is very important for survival, resulting in automatic shifts of attention to the event and the facilitation of subsequent processes to execute appropriate behaviors. The abrupt onset or offset of a sensory stimulus should also activate the neural network detecting...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1468-8
更新日期:2008-09-01 00:00:00
abstract::We examined the link between action planning and motor imagery in 6- and 8-year-old children. Action planning efficiency was assessed with a bar transport task. Motor imagery and visual imagery abilities were measured using a hand mental rotation task and a number (i.e., non-body stimuli) mental rotation task, respect...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3698-7
更新日期:2013-11-01 00:00:00
abstract::There is evidence that men experience more sexual arousal than women but also that women in mid-luteal phase experience more sexual arousal than women outside this phase. Recently, a few functional brain imaging studies have tackled the issue of gender differences as pertaining to reactions to erotica. The question of...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0429-3
更新日期:2006-09-01 00:00:00
abstract::This study examined perception-action learning in younger adults in their 20s compared to older adults in their 70s and 80s. The goal was to provide, for the first time, quantitative estimates of perceptuo-motor learning rates for each age group and to reveal how these learning rates change between these age groups. W...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3349-4
更新日期:2013-03-01 00:00:00
abstract::The goal of this study was to identify the control mechanism used for locomotion pointing regulation under different external temporal constraints. Subjects ( n=8) had to walk on a treadmill through a number of virtual hallways and cross a pair of gliding doors that opened and closed at a constant preset frequency (0....
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-001-0990-8
更新日期:2002-03-01 00:00:00
abstract::The motor cortex contains a distributed map of muscles, with a single muscle represented over a wide cortical area. We have searched for inter-connections between distant sites projecting to common muscles by delivering pairs of 20-microA single-pulse intracortical microstimuli (ICMS) to sites separated by 1.5-2 mm in...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050585
更新日期:1998-12-01 00:00:00
abstract::Here we aim to evaluate the ability of transcranial direct current stimulation (tDCS), which is applied over Wernicke's area and its right homologue, to influence lexical decisions and semantic priming and establish an involvement for temporo-parietal areas in lexical and semantic processing. Thirty-two subjects (17 w...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-013-3416-5
更新日期:2013-04-01 00:00:00
abstract::In 15 musicians, cortical DC-potentials were recorded from the scalp before and during the execution of bimanual motor sequences. Subjects (Ss) either tapped with their two index fingers in synchrony (quavers against quavers; "2 against 2") or they tapped quavers against triplets ("2 against 3"). Either the right or t...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229320
更新日期:1990-01-01 00:00:00
abstract::It is well established that neuronal transmission from the entorhinal cortex through the dentate gyrus via the perforant path is dependent on behavioral state. To further study the modulation of neuronal transmission by behavioral state we employed the paired-pulse technique to study interneuronally-mediated inhibitio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00249612
更新日期:1989-01-01 00:00:00
abstract::In studies of human eye-head coordinated saccadic gaze shifts, different laboratories have found greatly different magnitudes of head movements for a given amplitude of gaze shift (head movement gain). The present study was conducted to examine why, and to quantify volitional head movements. Fixation/target lights wer...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230391
更新日期:1992-01-01 00:00:00
abstract::Selective attention is popularly assessed with colour Stroop tasks in which participants name the ink colour of colour words, whilst resisting interference from the natural tendency to read the words. Prior studies hinted that the key brain regions (dorsolateral prefrontal (dlPFC) and anterior cingulate cortex (ACC)) ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2225-3
更新日期:2010-05-01 00:00:00