Abstract：
:To address the hypothesis that Parkinson's disease (PD) patients have deficits in controlling acceleration, a drawing task was used in which target size, frequency, and weight of pen were manipulated. In accordance with previous results, it was found that, relative to controls, PD patients produced movements at the required frequency, but moved significantly slower, produced less acceleration, and drew smaller-than-required stroke sizes. This resulted in smaller-than-required movement amplitudes, suggesting that hypometria and bradykinesia in drawing and/or handwriting are related. Patients were found to perform similarly to controls when the target size was 1 cm. However, their performance became more dissimilar at greater stroke lengths. In addition to the aforementioned effects it was found that movement amplitude error was less when the pen was 20 times heavier than the normal pen and that the increased load may dampen abnormal limb-stiffness characteristics induced by PD.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Broderick MP,Van Gemmert AW,Shill HA,Stelmach GEdoi
10.1007/s00221-009-1925-zsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
223-33issue
3eissn
0014-4819issn
1432-1106journal_volume
197pub_type
杂志文章abstract：PURPOSE:To examine the accuracy and latency of reflexive saccades to vibratory stimulation of the fingertips made by normal human subjects and to compare the findings to those of visually guided saccades. METHODS:Eye movements were recorded using infrared oculography. Stimuli were presented via an array of audiometric...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1749-1
更新日期：2004-02-01 00:00:00
abstract：:We investigated the effect of musical expertise on sensitivity to asynchrony for drumming point-light displays, which varied in their physical characteristics (Experiment 1) or in their degree of audiovisual congruency (Experiment 2). In Experiment 1, 21 repetitions of three tempos x three accents x nine audiovisual d...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1817-2
更新日期：2009-09-01 00:00:00
abstract：:We investigated the association between the degree of lesion overlap with the corticospinal tract and walking performance before and after 4-weeks of partial body weight support (PBWS) treadmill training in 18 individuals (ten male, eight female) with a mean age 59 +/- 13 years (mean +/- SD), range 32-74 years, who we...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-1237-0
更新日期：2008-03-01 00:00:00
abstract：:Abnormal automatic postural responses are thought to contribute to balance impairment in Parkinson's disease. However, because postural responses are modifiable by stance, we have speculated that some postural abnormalities in patients with Parkinson's disease are secondary to their stooped stance. We have studied thi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050644
更新日期：1999-02-01 00:00:00
abstract：:Gait is recognized as a key item related to mental function. Anomalous gait in psychotic individuals has been described for the lower extremities, whereas irregularities for upper body dynamics are not described, explained or verified with unbiased methods. Reduced walking velocity and increased somatic tension define...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-012-3184-7
更新日期：2012-09-01 00:00:00
abstract：:Coarticulation indicates a dependence of a movement segment on a preceding segment (carry-over coarticulation) or on the segment that follows (anticipatory coarticulation). Here we study coarticulation in multidegrees of freedom human arm movements. We asked participants to transport a cylinder from a starting positio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4327-4
更新日期：2015-09-01 00:00:00
abstract：:It has been hypothesized that the steady-state response to a periodic sequence of clicks can be modeled as the superposition of responses to single clicks. Here, this hypothesis is challenged by presenting an extra click halfway between two consecutive clicks of a regular series, while measuring the auditory evoked fi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4260-6
更新日期：2015-06-01 00:00:00
abstract：:Dissociated cell suspensions were prepared from the ventral midbrain of normal mouse foetuses and stereotaxically implanted into the neostriatum of 2-3 months old homozygous weaver mutant mice, which are severely deficient in dopamine. In tests of amphetamine-induced turning behaviour 60 days after grafting, recipient...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228869
更新日期：1990-01-01 00:00:00
abstract：:The primary objective of this study was to explore why preischemic hypoglycemia, which restricts tissue acidosis during the ischemic insult, does not ameliorate cell damage incurred as a result of transient ischemia. The question arose whether hypoglycemia (plasma glucose concentration 2-3 mM) delays resumption of ext...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00233036
更新日期：1995-01-01 00:00:00
abstract：:Corticomotor control of the human tongue has been reported to undergo neuroplastic changes following several days of training in a tongue-protrusion task. The aims of the present study were to determine if a 1 h tongue-task training is sufficient to induce signs of neuroplastic changes in the corticomotor pathways, an...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0380-3
更新日期：2006-08-01 00:00:00
abstract：:In 11 squirrel monkeys (Saimiri sciureus), the brain stem was systematically explored with electrical brain stimulation for sites affecting the acoustic structure of ongoing vocalization. Vocalization was elicited by electrical stimulation of different brain structures. A severe deterioration of the acoustical structu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229880
更新日期：1992-01-01 00:00:00
abstract：:In cats anaesthetised with pentobarbitone, the effect of inhibitors of the in vitro cellular uptake of GABA were tested on the responses of single central neurones to GABA and other depressant amino acids. (4)- AND (-)-nepecotic acid, (4)-2,4-diaminobutyric acid (DABA) and 2,2-dimethyl-beta-alanine, enhanced the actio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241731
更新日期：1976-06-30 00:00:00
abstract：:The acquisition of co-ordination between posture and movement was investigated in human subjects performing a load lifting task. Sitting subjects held their left (postural) forearm in a horizontal position while supporting a 1 kg load via an electromagnet. Perturbation of the postural forearm position consisted of the...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00274991
更新日期：1989-01-01 00:00:00
abstract：:Experimental behavioral data show that written action descriptions are remembered better when encoded by enacting them compared with merely verbal encoding. To explore this facilitating effect of encoding by performing actions ('enactment effect'), a functional magnetic resonance imaging (fMRI) study was conducted wit...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1398-4
更新日期：2003-04-01 00:00:00
abstract：:The firing of tuberoinfundibular neurones antidromically identified as projecting to the median eminence was recorded during electrical stimulation of the preoptic and/or anterior hypothalamic areas (PO/AH) of the rostral hypothalamus. Parameters of stimulation were chosen which are known to cause increased secretion ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237074
更新日期：1980-01-01 00:00:00
abstract：:The McGurk effect, which denotes the influence of visual information on audiovisual speech perception, is less frequently observed in individuals with autism spectrum disorder (ASD) compared to those without it; the reason for this remains unclear. Several studies have suggested that facial configuration context might...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5188-4
更新日期：2018-04-01 00:00:00
abstract：:Research has suggested that altering the perceived shape and size of the body image significantly affects perception of somatic events. The current study investigated how multisensory illusions applied to the body altered tactile perception using the somatic signal detection task. Thirty-one healthy volunteers were as...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4384-8
更新日期：2015-11-01 00:00:00
abstract：:Impaired plantar flexor muscle activation during push-off in late stance contributes importantly to reduced gait ability in adults with cerebral palsy (CP). Here we used low-intensity transcranial magnetic stimulation (TMS) to suppress soleus EMG activity during push-off as an estimate of corticospinal drive in CP adu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05520-3
更新日期：2019-06-01 00:00:00
abstract：:It was previously proposed that a linkage between the optokinetic system and the stereoscopic system in higher mammals serves to allow these animals to selectively stabilize those parts of the visual scene which lie in the plane of convergence as the animals move forward in a three-dimensional world (Howard and Ohmi, ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228902
更新日期：1989-01-01 00:00:00
abstract：:The aim of the present study was to assess the effects of dopaminergic medication on the selection-for-action mechanisms in Parkinson's disease (PD). PD subjects were tested after not having taken medication for at least 12 h ("Off' state) and then retested 1-2 h after medication ("On" state). A three-dimensional kine...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000510
更新日期：2000-11-01 00:00:00
abstract：:In recordings from two awake, behaving macaque monkeys we found that neurons in the crown of the prelunate gyrus differed in their responsiveness to simple visual stimuli. Neurons in the posterior part of the gyrus (area V4) responded strongly to stationary or moving bars, while neurons in the anterior part (area V4A)...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1112-y
更新日期：2002-07-01 00:00:00
abstract：:Recent studies suggest that recreational use of cocaine is associated with significant impairments in the same cognitive control functions that are affected by chronic use. Here we tested whether recreational cocaine use can impact the emergence and resolution of response conflict in conflict-inducing tasks. Recreatio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3724-9
更新日期：2014-01-01 00:00:00
abstract：:Chronic pain and gait variability in a dual-task situation are both associated with higher risk of falling. Executive functions regulate (dual-task) gait variability. A possible cause explaining why chronic pain increases risk of falling in an everyday dual-task situation might be that pain interferes with executive f...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4039-1
更新日期：2014-11-01 00:00:00
abstract：:Two rhesus monkeys were trained to make saccadic eye movements from a central fixation point towards a peripheral target. Saccadic reaction times (SRTs) were measured in the gap paradigm (200 ms pause between offset of fixation point and onset of peripheral target). Target position for extensive training (SRTs of 150 ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230109
更新日期：1990-01-01 00:00:00
abstract：:This study investigated the modulation of somatosensory evoked potentials (SEPs) during precisely controlled force generation and force relaxation in a visuomotor tracking task. Subjects were instructed to track a target line with a line that represented their own force generated by grip movement with the right hand a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3082-z
更新日期：2012-06-01 00:00:00
abstract：:In the present study, we investigated topographical differences between monocularly and binocularly evoked potential fields related to the retinal location and spatial frequency of grating stimuli. Electrical brain activity was recorded in 18 healthy adults using an array of 21 electrodes over the occipital areas. Ver...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229366
更新日期：1993-01-01 00:00:00
abstract：:In two experiments, we examined the effect of selective attention at encoding on repetition priming in normal aging and Alzheimer's disease (AD) patients for objects presented visually (experiment 1) or haptically (experiment 2). We used a repetition priming paradigm combined with a selective attention procedure at en...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1441-6
更新日期：2008-08-01 00:00:00
abstract：:Motor learning in the vestibular system can be differentially obtained depending upon the context for which the vestibulo-ocular reflex (VOR) has been exposed. Manipulating head orientation relative to gravity is an example of a contextual cue that can elicit independent VOR gains. We were interested in examining rete...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1289-9
更新日期：2008-05-01 00:00:00
abstract：:The photothrombotic ring stroke model with sustained underperfusion followed by late spontaneous reperfusion (Gu et al. 1999) was employed to study its morphological consequences. The exposed crania of adult male Wistar rats were subjected to a ring-shaped laser irradiation beam simultaneously with intravenous erythro...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050672
更新日期：1999-03-01 00:00:00
abstract：:Intraparenchymal injections of the neurotoxin 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle in rats destroys the dopaminergic neurons in the pars compacta of the substantia nigra. In other transmitter systems it has been found that axotomy or neurotoxin exposure produces an initial loss of neurotransmitt...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229549
更新日期：1996-09-01 00:00:00
