Abstract:
:Two rhesus monkeys were trained to make saccadic eye movements from a central fixation point towards a peripheral target. Saccadic reaction times (SRTs) were measured in the gap paradigm (200 ms pause between offset of fixation point and onset of peripheral target). Target position for extensive training (SRTs of 150 to 250 saccades were collected per day) was four degrees eccentric in the lower quadrant of the visual field contralateral to the intended lesion site in area V4. For control the monkeys were also trained for target positions either in the lower quadrant ipsilateral to the intended lesion site or in the upper visual half field. After several weeks of training a bimodal distribution of saccadic reaction times, one peak at 85 ms (express saccades) and the other around 160 ms (regular saccades) was obtained for each target position. Local injection of ibotenic acid into the 4 deg representation of area V4 resulted in a unimodal distribution of saccadic reaction times (over 90% express saccades) towards the corresponding target position, leaving the distribution of reaction times for the control position unchanged. Recovery began after 5 days and was complete 8 to 10 days after the injection. From these results we conclude that V4 is involved in the generation of the longer latency peak in the distribution of saccadic reaction times by delaying the initiation of visually guided saccades.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Weber H,Fischer Bdoi
10.1007/BF00230109subject
Has Abstractpub_date
1990-01-01 00:00:00pages
134-9issue
1eissn
0014-4819issn
1432-1106journal_volume
81pub_type
杂志文章abstract::This study assessed the effects of operant conditioning of the H-reflex on motoneuron axonal conduction velocity in the rat. After measurement of the control H-reflex size, rats were either exposed for at least 40 days to the HRup or HRdown conditioning mode, in which reward occurred only if the soleus H-reflex was gr...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000608
更新日期:2001-01-01 00:00:00
abstract::Second-order vestibular neurons of frogs receive converging monosynaptic excitatory and disynaptic excitatory and inhibitory inputs following electrical pulse stimulation of an individual semicircular canal nerve on the ipsilateral side. Here we revealed, in the in vitro frog brain, disynaptic inhibitory postsynaptic ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000544
更新日期:2000-12-01 00:00:00
abstract::In order to study neuronal information transfer from the striatum to the globus pallidus (GP) during voluntary movement, we recorded activity of electrophysiologically identified projection neurons in the putamen to the GP while the monkey was performing learned movement tasks. Two categories of putamen neurons were r...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228811
更新日期:1990-01-01 00:00:00
abstract::Local anesthetic may cause neurotoxicity in developing neurons. In this study, we examined the molecular mechanisms of microRNA-210 (miR-210) in regulating bupivacaine-induced dorsal root ganglia (DRG) neurotoxicity in vitro. Young mouse (P30) DRG explants were cultured in vitro and treated with 5 mM bupivacaine to in...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4513-4
更新日期:2016-04-01 00:00:00
abstract::Previous studies have demonstrated the importance of both kinesthetic and auditory feedback for control of voice fundamental frequency (F0). In the present study, a possible interaction between auditory feedback and kinesthetic feedback for control of voice F0 was tested by administering local anesthetic to the vocal ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1330-z
更新日期:2008-06-01 00:00:00
abstract::Interval timing deficiencies in Parkinson's disease (PD) patients have been a matter of debate. Here we test the possibility of PD heterogeneity as a source for this discrepancy. Temporal performance of PD patients and control subjects was assessed during two interval tapping tasks and during a categorization task of ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1097-7
更新日期:2008-01-01 00:00:00
abstract::Extracellular Ca2+ activity (aCa) changes were measured with Ca2+-sensitive microelectrodes in the cat cerebral cortex during iontophoretic administration of excitatory and inhibitory aminoacids. Glutamate, aspartate and DL homcysteate usually decreased aCa from a baseline of 1.3 mM to as low as 0.1 mM. The amplitude ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237788
更新日期:1980-01-01 00:00:00
abstract::Fast goal-directed voluntary movements of the human upper extremity are known to be associated with three distinct bursts of EMG activity in antagonistic muscles. The role of each burst (AG1, ANT, AG2) in controlling motion is not fully understood, largely because overall limb response is a complex function of the ent...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236850
更新日期:1986-01-01 00:00:00
abstract::We previously described significant relationships between amplitude variations in slow brain potentials and timed between-press intervals (2.5 s). We suggested that these variations are neural traces of timing mechanisms. To determine which time processing stage is concerned, the current study examines whether these v...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1103-z
更新日期:2002-08-01 00:00:00
abstract::This kinematic study aimed to determine whether color is a stimulus property involved in the control of reaching-grasping movements. Subjects reached and grasped a target-object, located either on the right or on the left of the subject's midline. A distractor, placed along the subject's midline, could be randomly pre...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000639
更新日期:2001-03-01 00:00:00
abstract::Our previous study showed an increase in total cholesterol level of the hippocampus after kainate-induced injury, but whether this is further metabolized to neurosteroids is not known. The first step in neurosteroid biosynthesis is the conversion of cholesterol to pregnenolone by the enzyme cytochrome P450 side chain ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1209-4
更新日期:2008-03-01 00:00:00
abstract::In order to navigate efficiently, animals can benefit from internal representations of their moment-to-moment orientation. Head-direction (HD) cells are neurons that discharge maximally when the head of a rat is oriented in a specific ("preferred") direction in the horizontal plane, independently from position or ongo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000365
更新日期:2000-07-01 00:00:00
abstract::Vestibular perceptual thresholds measure vestibular sensory and perceptual noise by quantifying how small of a passive self-motion an individual is able to reliably perceive. Vestibular thresholds have clinical and operational relevance, as they are elevated in vestibular migraine patients, and even healthy individual...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05830-x
更新日期:2020-06-01 00:00:00
abstract::In convergent strabismus (esotropia) the spatial asynchrony of the two eye inputs unbalances the interocular interactions, leading to the functional advantage of the nondeviated eye and the inhibition of the esotropic eye. It may be argued that the strabismic suppression, if it is the effect of inhibitory interactions...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1190-x
更新日期:2002-11-01 00:00:00
abstract::The effect of claustrum (CL) stimulation on the spontaneous unitary activity of ipsi and contralateral frontal oculomotor neurons, was studied in chloralose-anaesthetized cats. A total of 205 units was bilaterally recorded in the medial oculomotor area, homologous of the primate "frontal eye fields"; 127 neurons were ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230958
更新日期:1991-01-01 00:00:00
abstract::An aberrant crossed corticotectal pathway can be generated by removal of one visual cortex and the contralateral superior colliculus from newborn rats. This aberrant crossed corticotectal projection arises from the pyramidal neurons located in layer V of the visual cortex and terminates in a spatially orderly manner i...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235562
更新日期:1978-11-15 00:00:00
abstract::We sought to determine whether motor evoked potentials (MEPs) as well as silent periods could be produced in hand and shoulder muscles by transcranial magnetic stimulation (TMS) of the ipsilateral cerebral hemisphere and, if so, whether their cortical representations could be mapped with respect to those of contralate...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00227284
更新日期:1994-01-01 00:00:00
abstract::Previous work has indicated that people do not use their judgment of a target's speed to determine where to hit it. Instead, they use their judgment of the target's changing position and an expected speed (based on the speed of previous targets). In the present study we investigate whether people also ignore the targe...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1556-8
更新日期:2003-10-01 00:00:00
abstract::Nonlinear analysis of the multifocal cortical visual evoked potential has allowed the identification of neural generation of higher-order nonlinear components by magnocellular and parvocellular neural streams. However, the location of individual brain sources that make such contributions to these evoked responses has ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4601-0
更新日期:2016-07-01 00:00:00
abstract::Dual task paradigms can be used to examine the interactions between cognition and the control of posture and gait. Measuring and interpreting changes in dual task performance is challenging, however, because many factors can influence performance. This study examined the effects of instructed focus and walking task di...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2429-6
更新日期:2010-11-01 00:00:00
abstract::The neural activity in area 7a and the arm area of motor cortex was recorded while real or path-guided apparent motion stimuli were presented to behaving monkeys in the absence of a motor response. A smooth stimulus motion was produced in the real motion condition, whereas in the apparent motion condition five stimuli...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1664-5
更新日期:2004-02-01 00:00:00
abstract::Fourteen healthy adults were tested to assess the potential influence on stance maintenance of two parts of the visual feedback technique (display scale and time delay). The task consisted in their keeping a spot on the screen representing their center of pressure, CoP (i.e. successive points of application of the gro...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2288-8
更新日期:2005-08-01 00:00:00
abstract::Previous studies have shown that the vestibular short-latency-evoked potential (VsEP) in response to the brief head acceleration stimulus is a compound action potential of neurons innervating the otolith organs. However, due to the lack of direct evidence, it is currently unclear whether the VsEP is primarily generate...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3602-5
更新日期:2013-08-01 00:00:00
abstract::Studies of movement-related cortical potentials (MRCPs) for simple movements have shown a slowly rising negativity (Bereitschaftspotential, or BP) about 2 s prior to movement onset, centered in the bilateral sensorimotor area. However, complex movements may elicit a different temporal and spatial distribution of this ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2314-x
更新日期:2005-06-01 00:00:00
abstract::Parkinson's disease (PD) adversely affects information processing and motor performance. The impact of aerobic exercise on modifying the deleterious effects of PD underlying information and motor control processes is not well established. The primary aim of this project was to determine the effects of an 8-week high i...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-06009-0
更新日期:2021-01-04 00:00:00
abstract::This study examined the hypothesis that the mirror reflection of one hand's movement directly influences motor output of the other (hidden) hand, during performance of bimanual drawing. A mirror was placed between the two hands during bimanual circle drawing, with one hand and its reflection visible and the other hand...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-1831-3
更新日期:2004-07-01 00:00:00
abstract::Multichannel surface EMG recordings of a multiheaded skeletal muscle during cyclic locomotion combined with cineradiography were analysed in a chronic experiment. The resulting detailed two-dimensional activation pattern from the long and lateral triceps brachii heads of the rat during treadmill locomotion were combin...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100685
更新日期:2001-05-01 00:00:00
abstract::Previous research has indicated that rightward prism adaptation can reduce symptoms of spatial neglect following right brain damage. In addition, leftward prism adaptation can create "neglect-like" patterns of performance in healthy adults on tasks that measure attention and spatial biases. Although a great deal of re...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4678-5
更新日期:2016-10-01 00:00:00
abstract::The stronger anatomo-functional connections of the supplementary motor area (SMA), as compared with premotor area (PM), with regions of the limbic system, suggest that SMA could play a role in the control of movements triggered by visual stimuli with emotional content. We addressed this issue by analysing the modifica...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1346-8
更新日期:2003-03-01 00:00:00
abstract::The aim of this work was to study the neurochemical effects in the brain of GABA-transaminase inhibition by systemic administration of gabaculine (100 mg/kg, i.a.) in the rat. In order to investigate neurotransmitter and related amino-acid compartmentation and metabolism, we have developed an original tool: the coupli...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050802
更新日期:1999-08-01 00:00:00