Abstract:
:The aim of the present study was to assess the effects of dopaminergic medication on the selection-for-action mechanisms in Parkinson's disease (PD). PD subjects were tested after not having taken medication for at least 12 h ("Off' state) and then retested 1-2 h after medication ("On" state). A three-dimensional kinematic system (ELITE, BTS, Italy) was used to record reach-to-grasp movements to a target object placed at a reaching distance of 30 cm. The target was presented alone or in the presence of distractor objects, which could be of either the same size (compatible distractor) or a different size (incompatible distractor). PD subjects in the Off state were significantly more affected by the presence of the incompatible distractor than in the On state. These results indicate that dopaminergic medication is of benefit in reducing interference effects when distractor objects evoke motor programs that differ from the motor program elicited by the target. Results are discussed in light of the role played by the striatal and mesocortical dopaminergic systems for response selection in basal ganglia disorders.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Castiello U,Bonfiglioli C,Peppard RFdoi
10.1007/s002210000510keywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
251-8issue
2eissn
0014-4819issn
1432-1106journal_volume
135pub_type
杂志文章abstract::The parietal lobes contribute to body-space representation. The present work aims at characterizing the functional role of the inferior parietal lobe in body-space representation and at studying the different roles of the angular gyrus in the right and left hemisphere. We conducted three separate transcranial direct c...
journal_title:Experimental brain research
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journal_title:Experimental brain research
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