Abstract：
:Survivin attenuates apoptosis by inhibiting cleavage of some cell proteins by activated caspase-3. We recently discovered strong up-regulation of survivin, primarily in astrocytes and a sub-set of neurons, after traumatic brain injury (TBI) in rats. In this study we characterized co-expression of survivin with activated caspase-3 and downstream DNA fragmentation (TUNEL) in astrocytes and neurons after TBI. Western blot analysis revealed significant time-dependent increases in active caspase-3 between 5 and 14 days post-injury. No difference was observed between the proportion of survivin-positive and survivin-negative cells labeled with active caspase-3 at 5 or 7 days post-injury, as indicated by dual fluorescent immunostaining. Labeling of survivin-negative cells with TUNEL was, however, significantly greater than for survivin-positive cells, suggesting that expression of survivin may attenuate DNA cleavage and progression of apoptosis. A higher proportion of astrocytes than neurons accumulated active caspase-3. In contrast, co-localization with TUNEL was significantly higher for neurons than for astrocytes. These data suggest that survivin expression may attenuate DNA cleavage and cell death, and that this mechanism operates in a cell type-specific manner after TBI.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Johnson EA,Svetlov SI,Wang KK,Hayes RL,Pineda JAdoi
10.1007/s00221-005-2362-2keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
17-26issue
1eissn
0014-4819issn
1432-1106journal_volume
167pub_type
杂志文章abstract：:There is still controversy in the literature whether a single episode of mild traumatic brain injury (MTBI) results in short-term functional and/or structural deficits as well as any induced long-term residual effects. With the inability of traditional structural brain imaging techniques to accurately diagnosis MTBI, ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2294-3
更新日期：2010-07-01 00:00:00
abstract：:In the base of each temporal lobe in 4 monkeys (Macaca fascicularis) we sectioned the pia mater in an antero-posterior line along the most medial part of the inferior temporal visual association cortex (area TE), lateral to the parahippocampal cortex. This pial section interrupts the blood flow in branches of the post...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228525
更新日期：1991-01-01 00:00:00
abstract：:In cats anaesthetised with pentobarbitone, the effect of inhibitors of the in vitro cellular uptake of GABA were tested on the responses of single central neurones to GABA and other depressant amino acids. (4)- AND (-)-nepecotic acid, (4)-2,4-diaminobutyric acid (DABA) and 2,2-dimethyl-beta-alanine, enhanced the actio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241731
更新日期：1976-06-30 00:00:00
abstract：:Humans use a specific steering synergy, where the eyes and head lead rotation to the new direction, when executing a turn or change in direction. Increasing evidence suggests that eye movement is critical for turning control and that when the eyes are constrained, or participants have difficulties making eye movements...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3466-8
更新日期：2013-05-01 00:00:00
abstract：:The method of microneurography was used to record activity in trigeminal cutaneous and mucosal mechanoreceptive afferents during natural orofacial behaviors such as speech gestures, chewing, licking and swallowing. Multi-unit activity and impulses in single nerve fibers were recorded from the infraorbital nerve. It ap...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248519
更新日期：1988-01-01 00:00:00
abstract：:Hand shaping during prehension involves intricate coordination of a complex system of bones, joints, and muscles. It is widely hypothesized that the motor system uses strategies to reduce the degrees of independent control. Both biomechanical constraints that result in coupling of the fingers and joints and neural syn...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4117-4
更新日期：2015-02-01 00:00:00
abstract：:This study represents the first systematic comparison of the relative contributions of auditory and visual feedback to sequence production. Participants learned an isochronous melody that they performed on a keyboard and attempted to perform this sequence at a prescribed rate while auditory and visual feedback were ma...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3289-z
更新日期：2013-01-01 00:00:00
abstract：:Cells in cat's area 17 respond optimally if elongated contrasts are presented at a certain angle or orientation with respect to the retina, or to the visual field, respectively (Hubel and Wiesel, 1962). The preferred orientation and the range of orientation sensitivity of cells in close proximity to one another have b...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00234062
更新日期：1975-12-22 00:00:00
abstract：:In everyday life, we often use graphical interfaces where the visual space is mapped to the motor space with a visuomotor gain called the control display gain. One of the key objectives in the field of Human Computer Interaction is to design this control display gain so as to enhance users' performance. Although the c...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05856-1
更新日期：2020-09-01 00:00:00
abstract：:The response of 835 click-sensitive neurons in the inferior colliculus (IC) to ramp frequency modulated (FM) tones was studied in the anaesthetized rat. More than 70% of the cells were sensitive to the FM sound, and over 25% were "FM specialized". Systematic variations of the stimulus parameters showed that sweep velo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229838
更新日期：1991-01-01 00:00:00
abstract：:We recorded from 389 "reach" neurons (two monkeys) in the superior colliculus (SC) and underlying reticular formation (RF) or adjacent periaqueductal grey, whose activity was related to visually guided arm movements. Reach neurons were present from approximately 0.7 mm down to a depth of 6 mm below the surface of the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005691
更新日期：1997-06-01 00:00:00
abstract：:We determined whether uncertainty about the location of one's hand in virtual environments limits the efficacy of online control processes. In the Non-aligned and Aligned conditions, the participant's hand was represented by a cursor on a vertical or horizontal display, respectively. In the Natural condition, particip...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2487-9
更新日期：2011-02-01 00:00:00
abstract：:Anatomical studies in several species have demonstrated a pallidostriatal pathway. We employed electrophysiological and anatomical methods to distinguish the neurones of this pathway from the two pallidocortical groups reported in the rat. Injection of fluorescent retrograde tracers, combined with immunohistochemistry...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248863
更新日期：1989-01-01 00:00:00
abstract：:The electrophysiological properties of neurons of the medial septal nucleus and the nucleus of the diagnonal band of Broca (MS/DB) were studied using intracellular methods in urethane-anesthetized rats. Three types of rhythmically bursting neurons were identified in vivo on the basis of their action potential shapes a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005653
更新日期：1997-05-01 00:00:00
abstract：:Scientific interest has increased the influence of temperature in neurodegenerative and psychiatric disorders, and according to the monoamine hypothesis, depression is a neurochemical disorder arising from hypofunctioning of brain monoamine systems. Here, in vivo flow-oxymetry is applied to verify relationships betwee...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3443-2
更新日期：2013-10-01 00:00:00
abstract：:Geniculate cell responses to moving bars and moving texture were compared in normal cats and in cats in which the corticofugal feedback was removed by cortical ablation. In experimental animals the response strength and the velocity upper cutoff assessed with a moving bar was reduced compared to control animals. The s...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00608257
更新日期：1990-01-01 00:00:00
abstract：:Transient changes in extracellular potassium concentration ([K+]o) and field potentials were evoked by 4-aminopyridine (4-AP; 50-100 microM) and recorded with ion-selective microelectrodes in CA1b, CA3b and dentate sectors of adult rat hippocampal slices. Long-lasting field potentials recurred at a frequency of approx...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228628
更新日期：1996-04-01 00:00:00
abstract：:"Quiet standing" is standing without intended movement. To the naked eye, a person "quiet standing" on a rigid surface of support is stationary. In the laboratory quiet standing is indexed by behavior (at the millimeter scale) of the center of pressure (COP), the point location of the vertical ground reaction force ve...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3696-9
更新日期：2013-12-01 00:00:00
abstract：:Transcranial magnetic stimulation (TMS) has been first described 30 years ago, and since then has gained enormous attention by neurologists, psychiatrists, neurosurgeons, clinical neurophysiologists, psychologists, and neuroscientist alike. In the early days, it was primarily used to test integrity of the corticospina...
journal_title：Experimental brain research
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00221-016-4865-4
更新日期：2017-04-01 00:00:00
abstract：:Primary gaze fixation is never perfectly stable but can be interrupted by involuntary, conjugate saccadic intrusions (SI). SI have a high prevalence in the normal population and are characterised by a horizontal fast eye movement away from the desired eye position, followed, after a variable duration, by a return sacc...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2209-2
更新日期：2005-07-01 00:00:00
abstract：:We investigated the effect of different spatial and temporal parameters on the saccadic reaction times (SRTs) of the antisaccades and on the frequency and the SRTs of erratic prosaccades in five adult human subjects. The subjects were instructed to aim their saccades to the side opposite to where a visual go-stimulus ...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/pl00005749
更新日期：1997-09-01 00:00:00
abstract：:Mental imagery is considered to be important for normal conscious experience. It is most frequently investigated in the visual, auditory and motor domain (imagination of movement), while the studies on tactile imagery (imagination of touch) are scarce. The current study investigated the effect of tactile and auditory ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3020-0
更新日期：2012-05-01 00:00:00
abstract：:Few investigations have examined mental workload during motor practice or learning in a context of team dynamics. This study examines the underlying cognitive-motor processes of motor practice by assessing the changes in motor performance and mental workload during practice of reaching movements. Individuals moved a r...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5136-8
更新日期：2018-02-01 00:00:00
abstract：:It has been hypothesized that the steady-state response to a periodic sequence of clicks can be modeled as the superposition of responses to single clicks. Here, this hypothesis is challenged by presenting an extra click halfway between two consecutive clicks of a regular series, while measuring the auditory evoked fi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4260-6
更新日期：2015-06-01 00:00:00
abstract：:A simple model of the vestibuloocular reflex and the optokinetic system was used to simulate recent data on visual and vestibular responses of neurons in the vestibular nucleus. Contrary to a previous interpretation, the results support the hypothesis that the optokinetic and semicircular canal signals are combined si...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237269
更新日期：1977-11-24 00:00:00
abstract：:Adolescence is a transition period that is assumed to be characterized by increased sensitivity to reward. While there is growing research on reward processing in adolescents, investigations into the engagement of brain regions under different reward-related conditions in one sample of healthy adolescents, especially ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3272-8
更新日期：2012-11-01 00:00:00
abstract：:Inhibitory control plays an important role in goal-directed behavior. Although substantial inter-individual variability exists in the behavioral performance of response inhibition, the corresponding modulating neurochemical and neurophysiological mechanisms remain unclear. Thus, the present study aimed to explore the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5101-6
更新日期：2017-12-01 00:00:00
abstract：:We examined the distribution of labeled neurons in the parabigeminal nucleus of the monkey following injections of retrograde fluorescent tracers into the superior colliculus. The extent of the visual field representation included in the injection site was assessed from the location of labeled cells in striate cortex....
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230521
更新日期：1991-01-01 00:00:00
abstract：:Optimality criteria underlying organization of arm movements are often validated by testing their ability to adequately predict hand trajectories. However, kinematic redundancy of the arm allows production of the same hand trajectory through different joint coordination patterns. We therefore consider movement optimal...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-016-4610-z
更新日期：2016-06-01 00:00:00
abstract：:Two experiments were conducted to determine the effects of conditioned circling on the concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) within discrete regions of the striatum (STR). The first study assessed the inherent regional distributions of these compounds with ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247949
更新日期：1989-01-01 00:00:00
