Excitation and sensitization of nociceptors by bradykinin: what do we know?

Abstract:

:Bradykinin is an endogenous nonapeptide known to induce pain and hyperalgesia to heat and mechanical stimulation. Correspondingly, it excites nociceptors in various tissues and sensitizes them to heat, whereas sensitizing effect on the mechanical response of nociceptors is not well established. Protein kinase C and TRPV1 contribute to the sensitizing mechanism of bradykinin to heat. In addition, TRPA1 and other ion channels appear to contribute to excitation caused by bradykinin. Finally, prostaglandins sensitize bradykinin-induced excitation in normal tissues by restoring desensitized responses due to the inhibition of protein kinase A.

journal_name

Exp Brain Res

authors

Mizumura K,Sugiura T,Katanosaka K,Banik RK,Kozaki Y

doi

10.1007/s00221-009-1814-5

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

53-65

issue

1

eissn

0014-4819

issn

1432-1106

journal_volume

196

pub_type

杂志文章,评审
  • A margin for error in grasping: hand pre-shaping takes into account task-dependent changes in the probability of errors.

    abstract::Ideal grasping movements should maintain an appropriate probability of success, while controlling movement-related costs, in the presence of varying visual (and motor) uncertainty. It is often assumed that the probability of errors is managed by adjusting a margin for error in hand opening (e.g., opening the hand wide...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-019-05489-z

    authors: Keefe BD,Suray PA,Watt SJ

    更新日期:2019-04-01 00:00:00

  • Individual differences and the effect of face configuration information in the McGurk effect.

    abstract::The McGurk effect, which denotes the influence of visual information on audiovisual speech perception, is less frequently observed in individuals with autism spectrum disorder (ASD) compared to those without it; the reason for this remains unclear. Several studies have suggested that facial configuration context might...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-018-5188-4

    authors: Ujiie Y,Asai T,Wakabayashi A

    更新日期:2018-04-01 00:00:00

  • The development and recovery of motor function in spinal cats. I. The infant lesion effect.

    abstract::Normal development of motor function was compared to that of cats with spinal transections at birth (newborn operates) or at approximately two weeks after birth (two week operates). Newborn operates expressed motor behavior not seen until sometime later in normal newborn cats, suggesting that this behavior is normally...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00238857

    authors: Robinson GA,Goldberger ME

    更新日期:1986-01-01 00:00:00

  • Tapping effects on numerical bisection.

    abstract::Numerical magnitude is believed to be represented along a mental number line (MNL), and there is evidence to suggest that the activation of the MNL affects the perception and representation of external space. In the present study, we investigated whether a spatial motor task affects numerical processing in the auditor...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-010-2451-8

    authors: Cattaneo Z,Fantino M,Silvanto J,Vallar G,Vecchi T

    更新日期:2011-01-01 00:00:00

  • Cortical networks for visual reaching.

    abstract::The cortical anatomical substrates by which visual information may influence the frontal areas controlling reaching movements to visual targets were studied in monkeys. A reaching task was employed to characterize the arm-related regions of the frontal lobe. Injections of retrograde tracers into these physiologically ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00228707

    authors: Johnson PB,Ferraina S,Caminiti R

    更新日期:1993-01-01 00:00:00

  • Prenatal exposure to methylmercury alters locomotor activity of male but not female rats.

    abstract::In the present study the neurotoxic effects of a low dosage (0.5 mg/kg per day) of methylmercury (MeHg) on the developing nervous system were investigated. Pregnant rats were treated with MeHg from day 7 of pregnancy to day 7 of lactation. Locomotor activity (locomotion, rearing, and motility) and spatial learning abi...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050237

    authors: Rossi AD,Ahlbom E,Ogren SO,Nicotera P,Ceccatelli S

    更新日期:1997-12-01 00:00:00

  • Corticofugal influence on evoked activity of lateral geniculate neurons in the rabbit.

    abstract::Corticofugal influence upon lateral geniculate units was evaluated by inactivating the visual cortex with a topical application of 3M KCL in rabbits. The results revealed a decrease of spontaneous firing in slow P cells following cortical depression suggesting a tonic corticofugal influence. The most consistently obse...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236189

    authors: Molotchnikoff S,Lachapelle P

    更新日期:1977-09-28 00:00:00

  • Multiple timescales in postural dynamics associated with vision and a secondary task are revealed by wavelet analysis.

    abstract::Discrete wavelet analysis is used to resolve the center of pressure time series data into several timescale components, providing new insights into postural control. Healthy young and elderly participants stood quietly with their eyes open or closed and either performed a secondary task or stood quietly. Without visio...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-1915-1

    authors: Chagdes JR,Rietdyk S,Haddad JM,Zelaznik HN,Raman A,Rhea CK,Silver TA

    更新日期:2009-08-01 00:00:00

  • Orientation of Listing's plane in normals and in patients with unilateral vestibular deafferentation.

    abstract::The parameters characterizing Listing's plane have been determined in a group of normal subjects, and in patients who have had unilateral vestibular deafferentation on the right or left side. All patients were well compensated. There was no statistically significant difference in the orientation of Listing's plane bet...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00227346

    authors: Haslwanter T,Curthoys IS,Black R,Topple A

    更新日期:1994-01-01 00:00:00

  • Electrophysiological evidence for connections between septal neurones and the supraoptic nucleus of the hypothalamus of the rat.

    abstract::In order to see whether septal neurones are connected to the hypothalamic neurones secreting vasopressin or oxytocin, neurones in different regions of the septum were recorded during electrical stimulation of the supraoptic nucleus. The position of the stimulating electrode within the latter was verified using lactati...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00237493

    authors: Poulain DA,Lebrun CJ,Vincent JD

    更新日期:1981-01-01 00:00:00

  • Long-lasting aftereffect of a single prism adaptation: shifts in vision and proprioception are independent.

    abstract::After a single adaptation session to prisms with gradually incremented shift magnitude, the prism adaptation aftereffect was measured by open loop mid-sagittal pointing (O) to a visual target without visual feedback. This aftereffect corresponded to the summation of the shift in proprioception, measured by straight ah...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-006-0381-2

    authors: Hatada Y,Rossetti Y,Miall RC

    更新日期:2006-08-01 00:00:00

  • Multi-sensory integration of spatio-temporal segmentation cues: one plus one does not always equal two.

    abstract::How are multiple, multi-sensory stimuli combined for use in segmenting spatio-temporal events? For an answer, we measured the effect of various auditory or visual stimuli, in isolation or in combination, on a bistable percept of visual motion ("bouncing" vs. "streaming"). To minimize individual differences, the physic...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-007-0897-0

    authors: Zhou F,Wong V,Sekuler R

    更新日期:2007-07-01 00:00:00

  • Smooth eye movements evoked by electrical stimulation of the cat's superior colliculus.

    abstract::Head-fixed gaze shifts were evoked by electrical stimulation of the deeper layers of the cat superior colliculus (SC). After a short latency, saccades were triggered with kinematics similar to those of visually guided saccades. When electrical stimulation was maintained for more than 150-200 ms, postsaccadic smooth ey...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00230420

    authors: Missal M,Lefèvre P,Delinte A,Crommelinck M,Roucoux A

    更新日期:1996-01-01 00:00:00

  • Familiar trajectories facilitate the interpretation of physical forces when intercepting a moving target.

    abstract::Familiarity with the visual environment affects our expectations about the objects in a scene, aiding in recognition and interaction. Here we tested whether the familiarity with the specific trajectory followed by a moving target facilitates the interpretation of the effects of underlying physical forces. Participants...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-014-4050-6

    authors: Mijatović A,La Scaleia B,Mercuri N,Lacquaniti F,Zago M

    更新日期:2014-12-01 00:00:00

  • Does calculating impair postural stabilization allowed by visual cues?

    abstract::In many daily situations, balance control is associated with a cognitive activity such as reading or a simple calculation. The objective of this study was to investigate the relationship between these two specific human activities, especially the influence of visual cues and support surface stability on body sway duri...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-014-3913-1

    authors: Ceyte H,Lion A,Caudron S,Kriem B,Perrin PP,Gauchard GC

    更新日期:2014-07-01 00:00:00

  • Short-interval intracortical inhibition in Parkinson's disease using anterior-posterior directed currents.

    abstract::Reduced short-interval intracortical inhibition (SICI) is reported in Parkinson's disease (PD) and is considered to reflect abnormal GABAergic inhibitory system of the primary motor cortex in PD. We have recently shown, however, that SICI using anterior-posterior directed currents in the brain was normal in focal dyst...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-011-2829-2

    authors: Hanajima R,Terao Y,Shirota Y,Ohminami S,Nakatani-Enomoto S,Okabe S,Matsumoto H,Tsutsumi R,Ugawa Y

    更新日期:2011-10-01 00:00:00

  • Binocular fixation in the rhesus monkey: spatial and temporal characteristics.

    abstract::The horizontal and vertical components of the positions of both eyes of rhesus monkeys were measured during periods of binocularly stable eye positions (eye pauses) while the animals fixated a small target. Differences between monocular and binocular viewing, as well as effects of target size and background illuminati...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236231

    authors: Motter BC,Poggio GF

    更新日期:1984-01-01 00:00:00

  • Axonal projections and conduction properties of olfactory peduncle neurons in the rat.

    abstract::Electrophysiological methods were employed to study the axonal properties of the neurons of anterior olfactory nucleus (AON), transition zone (TZ), and rostral prepyriform cortex (RPPC) and their projections towards the ipsilateral and contralateral olfactory bulb (IOB, COB) in the rat. Of 91 antidromically driven cel...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00237113

    authors: Moyano HF,Molina JC

    更新日期:1980-01-01 00:00:00

  • Influence of eye and head position on the vestibulo-ocular reflex.

    abstract::For the vestibulo-ocular reflex (VOR) to function properly, namely to ensure a stable retinal image under all circumstances, it should be able to take into account varying eye positions in the orbit and varying orientations of the head with respect to the axis about which it is rotating. We tested this capability by q...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00238215

    authors: Fetter M,Hain TC,Zee DS

    更新日期:1986-01-01 00:00:00

  • Single joint perturbation during gait: neuronal control of movement trajectory.

    abstract::The aim of this study was to investigate the effect of single joint displacement on the pattern of leg muscle electromyographic (EMG) activity during locomotion. For the first time, unilateral rotational hip or knee joint displacements were applied by a driven orthotic device at three phases of swing during locomotion...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-004-1904-3

    authors: Dietz V,Colombo G,Müller R

    更新日期:2004-10-01 00:00:00

  • Automatic postural responses in the cat: responses to headward and tailward translation.

    abstract::EMG responses, vertical and A-P shear forces and kinematics of "automatic postural responses" to unexpected translational perturbations in the headward and tailward directions were studied in cats. Muscles acting on the major joints of the forelimbs and hindlimbs were studied. Movement of the animals in response to pe...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00238231

    authors: Rushmer DS,Russell CJ,macpherson J,Phillips JO,Dunbar DC

    更新日期:1983-01-01 00:00:00

  • Accuracy of spatial localization depending on head posture in a perturbed gravitoinertial force field.

    abstract::Spatial orientation is crucial when subjects have to accurately reach memorized visual targets. In previous studies modified gravitoinertial force fields were used to affect the accuracy of pointing movements in complete darkness without visual feedback of the moving limb. Target mislocalization was put forward as one...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-004-2087-7

    authors: Prieur JM,Bourdin C,Vercher JL,Sarès F,Blouin J,Gauthier GM

    更新日期:2005-03-01 00:00:00

  • Intracellular calcium in mammalian brain cells: fluorescence measurements with quin2.

    abstract::Dispersed brain cells from 12-14 day old mouse embryos were loaded with the Ca2+-sensitive fluorescent probe, quin2 and shown to have a resting intracellular Ca2+ concentration ([Ca2+]i) of 158 nM (SE +/- 5) in the presence of 1 mM [Ca2+]o. When external [Ca2+] was raised from 0 to 1 mM there was an increase of [Ca2+]...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00235975

    authors: Morris ME,Friedlich JJ,MacDonald JF

    更新日期:1987-01-01 00:00:00

  • How two share two tasks: evidence of a social psychological refractory period effect.

    abstract::A strong assumption shared by major theoretical approaches to cognition posits that the human cognitive system has a limited capacity for information processing. Evidence supporting this claim comes from the dual-task paradigm in which one cognitive system has to process two tasks simultaneously. In this study, we exa...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-011-2703-2

    authors: Liepelt R,Prinz W

    更新日期:2011-06-01 00:00:00

  • Temporal discrimination of two passive movements in humans: a new psychophysical approach to assessing kinaesthesia.

    abstract::Percutaneous electrical stimulation of the motor point of the first dorsal interosseous muscle (FDI) was used to produce a non-painful contraction of the FDI muscle that caused index finger abduction movement but no radiating cutaneous paraesthesias or sharp sensations localized to joints. Pairs of stimuli separated b...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-005-2353-3

    authors: Tinazzi M,Stanzani C,Fiorio M,Smania N,Moretto G,Fiaschi A,Edwards MJ,Bhatia KP,Rothwell JC

    更新日期:2005-10-01 00:00:00

  • The intermuscular 3-7 Hz drive is not affected by distal proprioceptive input in myoclonus-dystonia.

    abstract::In dystonia, both sensory malfunctioning and an abnormal intermuscular low-frequency drive of 3-7 Hz have been found, although cause and effect are unknown. It is hypothesized that sensory processing is primarily disturbed and induces this drive. Accordingly, experimenter-controlled sensory input should be able to inf...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-010-2174-x

    authors: van der Meer JN,Schouten AC,Bour LJ,de Vlugt E,van Rootselaar AF,van der Helm FC,Tijssen MA

    更新日期:2010-05-01 00:00:00

  • Postural muscle activity during bilateral and unilateral arm movements at different speeds.

    abstract::The muscle activation patterns in anterior and posterior leg muscles were investigated with two types of perturbations to standing balance. Subjects stood with each foot on adjacent force platforms and performed arm flexion movements to shoulder height. Nine subjects performed ten repetitions unilaterally and bilatera...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-003-1732-x

    authors: Mochizuki G,Ivanova TD,Garland SJ

    更新日期:2004-04-01 00:00:00

  • Regularity in the generation of discharge patterns by primary and secondary muscle spindle afferents, as recorded under a ramp-and-hold stretch.

    abstract::The discharge frequency of primary (Ia) and secondary (II) muscle spindle afferents from the tibial anterior muscle of the cat were recorded under a ramp-and-hold stretch of the host muscle. The rate of ramp stretch and the prestretch of the muscle were varied systematically. The degree of stretch was kept constant. F...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00227509

    authors: Schäfer SS

    更新日期:1994-01-01 00:00:00

  • Convergence pattern of uncrossed excitatory and inhibitory semicircular canal-specific inputs onto second-order vestibular neurons of frogs. Organization of vestibular side loops.

    abstract::Second-order vestibular neurons of frogs receive converging monosynaptic excitatory and disynaptic excitatory and inhibitory inputs following electrical pulse stimulation of an individual semicircular canal nerve on the ipsilateral side. Here we revealed, in the in vitro frog brain, disynaptic inhibitory postsynaptic ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210000544

    authors: Straka H,Dieringer N

    更新日期:2000-12-01 00:00:00

  • Role of gravitational versus egocentric cues for human spatial orientation.

    abstract::Our perception of the vertical depends on allocentric information about the visual surrounds, egocentric information about the own body axis and gravicentric information about the pull of gravity. Previous work has documented that some individuals rely strongly on allocentric information, while others do not, and the ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-015-4526-z

    authors: Bury N,Bock O

    更新日期:2016-04-01 00:00:00