Abstract:
:Bradykinin is an endogenous nonapeptide known to induce pain and hyperalgesia to heat and mechanical stimulation. Correspondingly, it excites nociceptors in various tissues and sensitizes them to heat, whereas sensitizing effect on the mechanical response of nociceptors is not well established. Protein kinase C and TRPV1 contribute to the sensitizing mechanism of bradykinin to heat. In addition, TRPA1 and other ion channels appear to contribute to excitation caused by bradykinin. Finally, prostaglandins sensitize bradykinin-induced excitation in normal tissues by restoring desensitized responses due to the inhibition of protein kinase A.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Mizumura K,Sugiura T,Katanosaka K,Banik RK,Kozaki Ydoi
10.1007/s00221-009-1814-5subject
Has Abstractpub_date
2009-06-01 00:00:00pages
53-65issue
1eissn
0014-4819issn
1432-1106journal_volume
196pub_type
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