Abstract：
:Dispersed brain cells from 12-14 day old mouse embryos were loaded with the Ca2+-sensitive fluorescent probe, quin2 and shown to have a resting intracellular Ca2+ concentration ([Ca2+]i) of 158 nM (SE +/- 5) in the presence of 1 mM [Ca2+]o. When external [Ca2+] was raised from 0 to 1 mM there was an increase of [Ca2+]i of 70 nM; with further additions of Ca to greater than or equal to 10 mM [Ca2+]o the level of [Ca2+]i increased by less than or equal to 25 nM. Releasable intracellular Ca2+ stores, estimated from the increase in [Ca2+] produced by 4-Br A23187 in the absence of extracellular Ca2+, were 24 fmol/10(6) cells. A small increase in [Ca2+]i could be produced by the mitochondrial inhibitor, carbonyl cyanide m-chlorophenylhydrazone (CCCP). When extracellular K+ was raised by 10-20 mM, intracellular Ca2+ levels increased from 152 (SE +/- 7) to 204 nM (SE +/- 10). These K+-induced increases in [Ca2+]i were blocked by verapamil, did not occur in the absence of extracellular Ca2+, and presumably reflect the activation of voltage-dependent Ca2+ channels. N-methyl-D-aspartic acid (NMDA) evoked an increase in [Ca2+]i, while the kainate-like lathyrus sativus neurotoxin, L-3-oxalyl-amino-2-aminopropionic acid (L-3,2-OAP) did not; this is consistent with previous observations of different and respectively Ca2+-dependent and -independent mechanisms of action of these excitatory amino acids.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Morris ME,Friedlich JJ,MacDonald JFdoi
10.1007/BF00235975subject
Has Abstractpub_date
1987-01-01 00:00:00pages
520-6issue
3eissn
0014-4819issn
1432-1106journal_volume
65pub_type
杂志文章abstract：:Selective lesions of the noradrenergic locus coeruleus (LC) system have recently been shown to aggravate both ischemic and epileptic brain damage. This study explores the possibility that the LC system also influences hypoglycemic brain injury. Bilateral 6-hydroxydopamine lesions of the LC projection to the forebrain ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00279676
更新日期：1988-01-01 00:00:00
abstract：:The goal of this study was to determine the effect of changes in core body temperature on the resting discharge rate and sensitivity of vestibular-nerve afferents. Extracellular recordings were made from vestibular-nerve afferents innervating the semicircular canals in anesthetized C57BL/6 mice maintained at a core bo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2015-y
更新日期：2010-01-01 00:00:00
abstract：:Responses to pure visual stimuli and visual-vestibular interactions similar to those reported in other vertebrates were found in single vestibular nucleus neurons in cat. Contrary to prevailing hypotheses, the cerebellum is not an essential part of the pathway mediating these visual responses. ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239555
更新日期：1978-08-15 00:00:00
abstract：:Microinjections of D,L homocysteic acid (DLH, 40 nmoles) made in the lateral PAG of the unanesthetized and paralyzed decerebrate cat evoked distinct patterns of extracranial and hindlimb blood flow. One pattern, evoked from the pretentorial part of the lateral PAG (A3.3-A2.5), consisted of an extracranial vasodilation...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230972
更新日期：1991-01-01 00:00:00
abstract：:When two target elements are presented in close proximity, the endpoint of a saccade is generally positioned at an intermediate location ('global effect'). Here, we investigated whether the global effect also occurs for eye movements executed to distracting elements. To this end, we adapted the oculomotor capture para...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2602-6
更新日期：2011-04-01 00:00:00
abstract：:Studies of movement-related cortical potentials (MRCPs) for simple movements have shown a slowly rising negativity (Bereitschaftspotential, or BP) about 2 s prior to movement onset, centered in the bilateral sensorimotor area. However, complex movements may elicit a different temporal and spatial distribution of this ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-2314-x
更新日期：2005-06-01 00:00:00
abstract：:Associations between cognitive and motor timing performance are documented in hundreds of studies. A core finding is a correlation of about - 0.3 to - 0.5 between psychometric intelligence and time interval production variability and reaction time, but the nature of the relationship remains unclear. Here, we investiga...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05780-4
更新日期：2020-04-01 00:00:00
abstract：:The remote distractor effect is a robust finding whereby a saccade to a lateralised visual target is delayed by the simultaneous, or near simultaneous, onset of a distractor in the opposite hemifield. Saccadic inhibition is a more recently discovered phenomenon whereby a transient change to the scene during a visual t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1558-7
更新日期：2008-10-01 00:00:00
abstract：:1.) Eye movements were recorded in four Java monkeys (M. fascicularis) after unilateral microinjections (1 microliter, concentration 1 micrograms/microliter) of the GABA antagonist, bicuculline, and the GABA agonist, muscimol, into oculomotor related regions of the vestibular nuclei. Eye movements were investigated in...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228958
更新日期：1991-01-01 00:00:00
abstract：:Research in the vestibular field has revealed the existence of a central process, called 'velocity storage', that is activated by both visual and vestibular rotation cues and is modified by gravity, but whose functional relevance during natural motion has often been questioned. In this review, we explore spatial orien...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-011-2568-4
更新日期：2011-05-01 00:00:00
abstract：:We determined whether uncertainty about the location of one's hand in virtual environments limits the efficacy of online control processes. In the Non-aligned and Aligned conditions, the participant's hand was represented by a cursor on a vertical or horizontal display, respectively. In the Natural condition, particip...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2487-9
更新日期：2011-02-01 00:00:00
abstract：:Previous research has shown that Parkinson's-disease (PD) patients produce irregular movement paths during a rapid arm pointing task. The aim of this study was to investigate the movement paths of PD patients during a prehensile action to objects requiring different levels of precision. Thus, we sought to determine if...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000468
更新日期：2000-10-01 00:00:00
abstract：:The present experiment was designed to test the hypothesis that fatigue-induced impairment in movement accuracy is caused by a decrease in muscle cocontraction rather than a reduced ability to produce muscular force. Seven participants performed fast and accurate elbow extensions aimed at a target, before and after a ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-1264-x
更新日期：2008-02-01 00:00:00
abstract：:This study investigated the modulation of somatosensory evoked potentials (SEPs) during precisely controlled force generation and force relaxation in a visuomotor tracking task. Subjects were instructed to track a target line with a line that represented their own force generated by grip movement with the right hand a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3082-z
更新日期：2012-06-01 00:00:00
abstract：:Using different tracer substances the pathways connecting the superior colliculus with the diencephalon were studied in the Madagascan hedgehog tenrec (Echinops telfairi), a nocturnal insectivore with tiny eyes, a small and little differentiated superior colliculus and a visual cortex with no obvious fourth granular l...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228725
更新日期：1996-10-01 00:00:00
abstract：:We explored the action of digits during static prehension tasks involving one hand or two hands of one or two persons. Three hypotheses were tested: to prevent slippage of the object, grip force and safety margin (SM) would be largest in bimanual conditions, particularly involving two persons; the distribution of tang...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1662-8
更新日期：2009-03-01 00:00:00
abstract：:Motoneurones innervating the retractor bulbi muscle in the cat have been identified by retrograde labelling with horseradish peroxidase, by intracellular recording and by intracellular staining with horseradish peroxidase. Their somata are found in an accessory abducens nucleus, analogous to that described in some oth...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239148
更新日期：1979-02-15 00:00:00
abstract：:The aim of this study was to define the relative contribution of self-generated cutaneous and proprioceptive feedback to haptic shape discrimination by systematically constraining the exploratory strategy. Subjects (n = 23) explored pairs of two-dimensional (2-D) angles (standard angle, 90 degrees; comparison angles, ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0728-8
更新日期：2007-04-01 00:00:00
abstract：:The smooth-pursuit system uses retinal image-slip-velocity information of target motion to match eye velocity to actual target velocity. The caudal part of the frontal eye fields (FEF) contains neurons whose activity is related to direction and velocity of smooth-pursuit eye movements (pursuit neurons), and these neur...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1606-3
更新日期：2009-02-01 00:00:00
abstract：:Previously we described physiological properties of pontine reticulo-spinal neurons which generate bursts and decaying tonic discharges related to eye movements and neck muscle activity during ipsiversive gaze shifts (Grantyn and Berthoz 1987). Two of these "eye-neck reticulo-spinal neurons" (EN-RSN) were labeled by i...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00243310
更新日期：1987-01-01 00:00:00
abstract：:To date, tactile distractor processing has primarily been investigated by focusing on the spatial characteristics of distractors and the impact of their presentation on the orienting of attention. In two experiments, we examined the influence of tactile distractors when the location of stimulus presentation was kept c...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3929-6
更新日期：2014-07-01 00:00:00
abstract：:The purpose of this study was to investigate the temporal relationship between presaccadic neuronal discharges in the frontal eye fields (FEF) and supplementary eye fields (SEF) and the initiation of saccadic eye movements in macaque. We utilized an analytical technique that could reliably identify periods of neuronal...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241967
更新日期：1995-01-01 00:00:00
abstract：:Regulation of food intake is very important for health. It has been reported that people have decreased appetite at high altitude (HA). The current study recruited long-term HA residents to participate in an fMRI experiment which involved food craving. Result shows that the HA group showed decreased activation in the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2516-8
更新日期：2011-04-01 00:00:00
abstract：:Human orientation in novel and familiar environments is a complex skill that can involve numerous different strategies. To date, a comprehensive account of how these strategies interrelate at the behavioural level has not been documented, impeding the development of elaborate systems neuroscience models of spatial ori...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3316-0
更新日期：2013-02-01 00:00:00
abstract：:The activity of 28 cells located mainly in the secondary auditory cortex (A II) of awake squirrel-monkeys, was extracellularly recorded for periods of up to 6 h. Seven different species-specific vocalizations, which were repeatedly presented to the monkey, were used as auditory stimuli. Twenty-six cells responded, at ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239144
更新日期：1979-02-15 00:00:00
abstract：:Performing joint actions often requires precise temporal coordination of individual actions. The present study investigated how people coordinate their actions at discrete points in time when continuous or rhythmic information about others' actions is not available. In particular, we tested the hypothesis that making ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2706-z
更新日期：2011-06-01 00:00:00
abstract：:Haptic guidance has been shown to have both facilitatory and interfering effects on motor learning. Interfering effects have been hypothesized to result from the particular dynamic environment, which supports a passive role of the learner, and they should be attenuated by fading guidance. Facilitatory effects, in part...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3914-0
更新日期：2014-07-01 00:00:00
abstract：:The present experiment assessed the locomotor response to a low dose (1 mg/kg) of systemic D-amphetamine in rats with cytotoxic lesions of the retrohippocampus (entorhinal and extra-subicular cortices), compared with vehicle-operated shams and unoperated controls. Under spontaneous and saline conditions, both the sham...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241131
更新日期：1995-01-01 00:00:00
abstract：:The cerebellar projection from the facial and motor trigeminal nuclei was studied in the cat by means of retrograde axonal transport of wheat germ agglutinin-horseradish peroxidase and fluorescent tracers. The feline facial nucleus was cytoarchitectonically subdivided into ventromedial, ventrolateral, lateral, dorsal,...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247935
更新日期：1989-01-01 00:00:00
abstract：:The cerebral representation of space depends on the integration of many different sensory inputs. The vestibular system provides one such input and its dysfunction can cause profound spatial disorientation. Using positron emission tomography (PET), we measured regional cerebral perfusion with various vestibular stimul...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00241421
更新日期：1994-01-01 00:00:00
