Abstract：
:In the present study the neurotoxic effects of a low dosage (0.5 mg/kg per day) of methylmercury (MeHg) on the developing nervous system were investigated. Pregnant rats were treated with MeHg from day 7 of pregnancy to day 7 of lactation. Locomotor activity (locomotion, rearing, and motility) and spatial learning ability were tested in the offspring at 6 months of age. The expression of tyrosine hydroxylase (TH) was examined by immunohistochemistry and in situ hybridization. A significant decrease in spontaneous motility and rearing was observed only in the MeHg-treated male rats. After administration of a low dose of d-amphetamine (0.5 mg/kg) no differences could be observed between control and MeHg-treated male rats, suggesting that changes in dopaminergic transmission were involved. However, no change in TH messenger RNA expression was observed. No changes in spatial learning acquisition or memory were shown in MeHg-treated rats. Taken together, these findings show that during development a very low dosage of MeHg exerts neurotoxic effects detectable in adulthood, and that susceptibility is gender-dependent.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Rossi AD,Ahlbom E,Ogren SO,Nicotera P,Ceccatelli Sdoi
10.1007/s002210050237subject
Has Abstractpub_date
1997-12-01 00:00:00pages
428-36issue
3eissn
0014-4819issn
1432-1106journal_volume
117pub_type
杂志文章abstract：:The relations among spatial memory, Stroop-like colour-word subtests, and errors on antisaccade and memory-guided saccadic eye-movement trials for older and younger adults were tested. Two types of errors in the antisaccade task were identified: short latency prosaccade errors that were immediately corrected and longe...
journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00274981
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231171
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s00221-015-4473-8
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 更正并重新发布的文章,杂志文章
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更新日期：2004-07-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1995-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2018-7
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