Abstract：
:The action of delta-aminovaleric acid (AVA) on the muscle relaxant properties of baclofen, a GABAB receptor agonist, was investigated in two experimental models: (1) the pathologically increased muscle tone of the gastrocnemius muscle in spastic mutant Han-Wistar rats and (2) the Hoffmann (H)-reflex recorded from plantar foot muscles after electrical stimulation of the tibial nerve in barbiturate (60 mg/kg) anaesthetized rats. In both paradigms coadministration of AVA (500 nmol/5 microliter) antagonized the muscle relaxant action of intrathecally applied baclofen (0.2-2 nmol), but failed to affect the muscle relaxant effects of intrathecally injected muscimol (2-20 nmol). In contrast, coadministration of bicuculline (1 nmol) did block the muscle relaxant action of muscimol, but failed to alter the effects of baclofen. When administered alone, bicuculline (1 nmol), or AVA (500 nmol-2 mumol) were without intrinsic action in both paradigms. In an additional series of experiments we investigated the action of AVA on a supraspinal effect of baclofen. Coadministration of AVA (12.5 nmol/0.5 microliter) in the ventromedial thalamic nucleus antagonized the catalepsy induced by baclofen (ED50 10 pmol/0.5 microliter), as indicated by an increase in ED50 of baclofen by a factor of 4.835 and a parallel shift of the probit-log dosage regression line to the right. The parallel shift seems to be consistent with a competitive mechanism of action of AVA. This study presents evidence that AVA antagonizes central pharmacological actions of baclofen at both spinal and supraspinal sites without affecting the actions of a GABAA agonist, muscimol.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Schwarz M,Klockgether T,Wüllner U,Turski L,Sontag KHdoi
10.1007/BF00247610subject
Has Abstractpub_date
1988-01-01 00:00:00pages
618-26issue
3eissn
0014-4819issn
1432-1106journal_volume
70pub_type
杂志文章abstract：:The activity of 28 cells located mainly in the secondary auditory cortex (A II) of awake squirrel-monkeys, was extracellularly recorded for periods of up to 6 h. Seven different species-specific vocalizations, which were repeatedly presented to the monkey, were used as auditory stimuli. Twenty-six cells responded, at ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239144
更新日期：1979-02-15 00:00:00
abstract：:This study investigated whether the execution of an accurate pointing response depends on a prior saccade orientation towards the target, independent of the vision of the limb. A comparison was made between the accuracy of sequential responses (in which the starting position of the hand is known and the eye centred on...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00228987
更新日期：1994-01-01 00:00:00
abstract：:Stellate cells within the ventral cochlear nucleus (VCN) are a diverse cell group that have been classified according to their size and morphology. Some of these stellate cell types constitute major projection neurones into the brainstem and directly into the inferior colliculus, while others are implicated in more lo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1602-6
更新日期：2003-12-01 00:00:00
abstract：:X-ray photography was employed to analyse the postural syndromes following unilateral global and selective lesions of the vestibular apparatus in guinea pigs. Following hemilabyrinthectomy, head rotation in the horizontal plane resulted mainly from rotation of the cervical vertebrae whereas lateral head tilt was due t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00250579
更新日期：1989-01-01 00:00:00
abstract：:Extracellular Ca2+ activity (aCa) changes were measured with Ca2+-sensitive microelectrodes in the cat cerebral cortex during iontophoretic administration of excitatory and inhibitory aminoacids. Glutamate, aspartate and DL homcysteate usually decreased aCa from a baseline of 1.3 mM to as low as 0.1 mM. The amplitude ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237788
更新日期：1980-01-01 00:00:00
abstract：:The aim of the study was to investigate grip-load force regulation in Huntington's disease (HD) patients as compared to control subjects during the performance of a manipulative task that required rhythmical unimanual or bimanual isodirectional/non-isodirectional actions in the sagittal plane. Results showed that the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-001-0992-6
更新日期：2002-04-01 00:00:00
abstract：:Several recent studies indicate that saccades elicited in the absence of a visual target are slower than visually-guided movements of the same size. In addition, we have shown earlier that the slower saccades observed in two different paradigms had more asymmetrical (skewed) velocity profiles. Recently, it has been re...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00253624
更新日期：1989-01-01 00:00:00
abstract：:The effect of claustrum (CL) stimulation on the spontaneous unitary activity of ipsi and contralateral frontal oculomotor neurons, was studied in chloralose-anaesthetized cats. A total of 205 units was bilaterally recorded in the medial oculomotor area, homologous of the primate "frontal eye fields"; 127 neurons were ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230958
更新日期：1991-01-01 00:00:00
abstract：:The current study examined the EEG of young, old and old declined adults performing a visual paired associate task. In order to examine the effects of encoding context and stimulus repetition, target pairs were presented on either detailed or white backgrounds and were repeatedly presented during both early and late p...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2966-7
更新日期：2012-02-01 00:00:00
abstract：:Recent studies have demonstrated that dyslexia is associated with deficits in the temporal encoding of sensory information. While most previous studies have focused on information processing within a single sensory modality, it is clear that the deficits seen in dyslexia span multiple sensory systems. Surprisingly, al...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-005-2387-6
更新日期：2005-10-01 00:00:00
abstract：:EMG responses, vertical and A-P shear forces and kinematics of "automatic postural responses" to unexpected translational perturbations in the headward and tailward directions were studied in cats. Muscles acting on the major joints of the forelimbs and hindlimbs were studied. Movement of the animals in response to pe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238231
更新日期：1983-01-01 00:00:00
abstract：:It is known that, when both forearms are rotated rhythmically and symmetrically, the dominant hand leads in time by about 25 ms, irrespective of movement speed. Positron emission tomography was used to test the hypothesis that the asynchrony results from a functional hemispheric asymmetry. We found that in normal, adu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050428
更新日期：1998-06-01 00:00:00
abstract：:Postsynaptic potentials (PSPs) evoked in motoneurons innervating the back and abdominal muscles in the lumbar part of the body by stimulating hindlimb cutaneous afferents were investigated in unanesthetized decerebate and spinal cats. Various types of PSP: pure excitatory postsynaptic potential (EPSP), pure inhibitory...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050879
更新日期：1999-10-01 00:00:00
abstract：:Mental practice (MP) is a promising adjuvant to physical practice that involves many of the same mechanisms and takes on many of the same properties as physical practice. This study compared efficacy of a "massed" MP regimen versus a "distributed" MP regimen on upper extremity (UE) motor impairment and functional limi...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-016-4686-5
更新日期：2016-10-01 00:00:00
abstract：:The output from a motor nucleus is determined by the synaptic input to the motor neurons and their intrinsic properties. Here, we explore whether the source of synaptic inputs to the motor neurons (cats) and the age or post-stroke conditions (humans) may change the recruitment gain of the motor neuron pool. In cats, t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05628-6
更新日期：2019-11-01 00:00:00
abstract：:The ensemble properties of unit activity in the rat hippocampus were studied during different behavioral states defined by the presence or absence of the theta rhythm. A 24-channel microelectrode was used to monitor the parallel activity of several single neurons simultaneously. Individual units were characterized by ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239532
更新日期：1986-01-01 00:00:00
abstract：:Performing joint actions often requires precise temporal coordination of individual actions. The present study investigated how people coordinate their actions at discrete points in time when continuous or rhythmic information about others' actions is not available. In particular, we tested the hypothesis that making ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2706-z
更新日期：2011-06-01 00:00:00
abstract：:In our study we examined, in the rabbit, the interactions between temperature regulation and the state of increased vigilance and emotional arousal induced by a Classical Aversive Conditioning Procedure. A Delay Conditioning Procedure was used. The Conditioned Stimulus (CS) was a 1350 Hz, 85 dB tone, the Unconditioned...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238813
更新日期：1981-01-01 00:00:00
abstract：:Chronic pain and gait variability in a dual-task situation are both associated with higher risk of falling. Executive functions regulate (dual-task) gait variability. A possible cause explaining why chronic pain increases risk of falling in an everyday dual-task situation might be that pain interferes with executive f...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4039-1
更新日期：2014-11-01 00:00:00
abstract：:Past studies of the kinematics of human prehension have shown that varying object size affects the maximum opening of the hand, while varying object distance affects the kinematic profile of the reaching limb. These data contributed to the formulation of a theory that the reaching and grasping components of human preh...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231054
更新日期：1991-01-01 00:00:00
abstract：:Local alpha-band synchronization has been associated with both cortical idling and active inhibition. Recent evidence, however, suggests that long-range alpha synchronization increases functional coupling between cortical regions. We demonstrate increased long-range alpha and beta band phase synchronization during sho...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2086-9
更新日期：2010-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1675-3
更新日期：2009-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3696-9
更新日期：2013-12-01 00:00:00
abstract：:The goal of this study was to determine the effect of changes in core body temperature on the resting discharge rate and sensitivity of vestibular-nerve afferents. Extracellular recordings were made from vestibular-nerve afferents innervating the semicircular canals in anesthetized C57BL/6 mice maintained at a core bo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2015-y
更新日期：2010-01-01 00:00:00
abstract：:Experiments were carried out in urethane-anaesthetised rats to investigate whether GABA is involved in mediating inhibition of neuronal activity in the dorsal half of the periaqueductal grey matter (PAG) after stimulation of the serotonin-containing projection to the PAG from nucleus raphe obscurus (NRO). Multibarrell...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000627
更新日期：2001-03-01 00:00:00
abstract：:We investigated the effects of intracerebroventricular (i.c.v.) pertussis toxin upon the sensitivity of supraoptic oxytocin neurones to intravenous morphine (1-5000 micrograms/kg) in urethane-anaesthetized rats. The maximal inhibitory capacity of morphine was diminished by prior administration of pertussis toxin. Some...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230292
更新日期：1993-01-01 00:00:00
abstract：:It has recently been shown that spatially uninformative sounds can cause a visual stimulus to pop out from an array of similar distractor stimuli when that sound is presented in temporal proximity to a feature change in the visual stimulus. Until now, this effect has predominantly been demonstrated by using stationary...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2797-6
更新日期：2011-09-01 00:00:00
abstract：:The spatial frequency tuning and the contrast-response function of striate neurons in Siamese cats were investigated with drifting sinusoidal gratings of high contrast, and the results were compared to the data obtained in normally pigmented cats. The optimal spatial frequency of the tuning curves obtained from Siames...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236278
更新日期：1984-01-01 00:00:00
abstract：:Pain is a conscious experience, crucial for survival. To investigate the neural basis of pain perception in humans, a large number of investigators apply noxious stimuli to the body of volunteers while sampling brain activity using different functional neuroimaging techniques. These responses have been shown to origin...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-010-2340-1
更新日期：2010-08-01 00:00:00
abstract：:We used near-infrared spectroscopy to examine dorsolateral prefrontal cortex (DLPFC) activation over time in 10 children with or at-risk-for developmental coordination disorder (DCD) and 11 typically developing children (ages 8-12) during tasks involving executive processing. The groups performed with similar accuracy...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5358-4
更新日期：2018-11-01 00:00:00
