Abstract:
:Ideal grasping movements should maintain an appropriate probability of success, while controlling movement-related costs, in the presence of varying visual (and motor) uncertainty. It is often assumed that the probability of errors is managed by adjusting a margin for error in hand opening (e.g., opening the hand wider with increased visual uncertainty). This idea is intuitive, but non-trivial. It implies not only that the brain can estimate the amount of uncertainty, but also that it can compute how different possible alterations to the movement will affect the probability of errors-which we term the 'probability landscape'. Previous work suggests the amount of uncertainty is factored into grasping movements. Our aim was to determine whether grasping movements are also sensitive to the probability landscape. Subjects completed three different grasping tasks, with naturally different probability landscapes, such that appropriate margin-for-error responses to increased uncertainty were qualitatively different (opening the hand wider, the same amount, or less wide). We increased visual uncertainty by blurring vision, and by covering one eye. Movements were performed without visual feedback to isolate uncertainty in the brain's initial estimate of object properties. Changes to hand opening in response to increased visual uncertainty closely resembled those predicted by the margin-for-error account, suggesting that grasping is sensitive to the probability landscape associated with different tasks. Our findings therefore support the intuitive idea that grasping movements employ a true margin-for-error mechanism, which exerts active control over the probability of errors across changing circumstances.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Keefe BD,Suray PA,Watt SJdoi
10.1007/s00221-019-05489-zsubject
Has Abstractpub_date
2019-04-01 00:00:00pages
1063-1075issue
4eissn
0014-4819issn
1432-1106pii
10.1007/s00221-019-05489-zjournal_volume
237pub_type
杂志文章abstract::The pharmacology of synaptic transmission was studied in slices of rat piriform cortex using the selective non-NMDA glutamate receptor antagonist 6.7-dinitroquinoxaline-2,3-dione (DNQX) and the selective NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5). DNQX produced a dose-dependent blockade of synapt...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231264
更新日期:1990-01-01 00:00:00
abstract::We investigated the extent to which humans can quickly adapt their goal-directed arm movements to perturbed feedback. We predicted that the magnitude of adaptation to a changed relationship between vision and kinesthesia would depend on the type of perturbation, being largest when the perturbation can be generalized w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1321-4
更新日期:2003-02-01 00:00:00
abstract::Humans are known to show anticipatory adjustments in the grip force prior to a self-generated or predictable action or perturbation applied to a hand-held object. We investigated whether humans can also adjust covariation of individual finger forces (multi-finger synergies) prior to self-triggered perturbations. To ad...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0583-7
更新日期:2006-11-01 00:00:00
abstract::The present study aimed at determining whether the observation of two functionally compatible artefacts, that is which potentially concur in achieving a specific function, automatically activates a motor programme of interaction between the two objects. To this purpose, an interference paradigm was used during which a...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3047-2
更新日期:2012-05-01 00:00:00
abstract::Anxious individuals have been shown to interpret others' emotional states negatively. Since most studies have used facial expressions as emotional cues, we examined whether trait anxiety affects the recognition of emotion in a dynamic face and voice that were presented in synchrony. The face and voice cues conveyed ei...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2668-1
更新日期:2011-09-01 00:00:00
abstract::Prism adaptation (PA) is a promising rehabilitation technique for visuo-spatial neglect, an attention disorder that is characterized by spatial attention deficits (i.e., deficits in orienting). PA involves visuo-motor adaptation to rightward shifting prism goggles. Following goggle removal, this adaptation results in ...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-015-4218-8
更新日期:2015-05-01 00:00:00
abstract::It has been hypothesized that the steady-state response to a periodic sequence of clicks can be modeled as the superposition of responses to single clicks. Here, this hypothesis is challenged by presenting an extra click halfway between two consecutive clicks of a regular series, while measuring the auditory evoked fi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4260-6
更新日期:2015-06-01 00:00:00
abstract::The size-weight illusion induced by visually perceived sizes was reexamined to investigate whether this illusion is a sensory based or cognitive-based phenomenon. A computer-augmented environment was utilized to manipulate visual size information of target objects independently of their haptic information. Two physica...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0803-1
更新日期:2007-05-01 00:00:00
abstract::Selective lesions of the noradrenergic locus coeruleus (LC) system have recently been shown to aggravate both ischemic and epileptic brain damage. This study explores the possibility that the LC system also influences hypoglycemic brain injury. Bilateral 6-hydroxydopamine lesions of the LC projection to the forebrain ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00279676
更新日期:1988-01-01 00:00:00
abstract::Rats kept in the dark (i.e., less than 0.1 lux) from birth until 15 days were exposed to light. In vivo incorporation of 14C-leucine into acid insoluble material and in vitro aminoacylation of tRNAleu were studied in visual, somaesthetic and motor brain cortices. A significant increase of both 14C-leucine incorporatio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239035
更新日期:1977-04-21 00:00:00
abstract::Hemi-seesaw nystagmus (hemi-SSN) is a jerk-waveform nystagmus with conjugate torsional and disjunctive vertical components. Halmagyi et al. in Brain 117(Pt 4):789-803 (1994), reported hemi-SSN in patients with unilateral lesions in the vicinity of the Interstitial Nucleus of Cajal (INC) and suggested that an imbalance...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2376-2
更新日期:2010-09-01 00:00:00
abstract::The effects of L-DOPA, naloxone, and the opioids (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO) and D-Ser2-Leu-enkephalin-Thr6 (DSLET) on spinal motor rhythm generation were compared in anemically decapitated high spinal cats. After premedication with nialamide, DOPA caused the well-known, slow rhythmic motor activity w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241493
更新日期:1995-01-01 00:00:00
abstract::In a previous study, we assessed the synchronous neural interactions (SNI) in a developing neural network in brain cultures on multielectrode arrays (Christopoulos et al. in J Neural Eng 9:046008, 2012). Here, we report on the effects of apolipoprotein E4 (apoE4) on these neural interactions. We carried out six experi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4270-4
更新日期:2015-06-01 00:00:00
abstract::The parietal lobes contribute to body-space representation. The present work aims at characterizing the functional role of the inferior parietal lobe in body-space representation and at studying the different roles of the angular gyrus in the right and left hemisphere. We conducted three separate transcranial direct c...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3538-9
更新日期:2013-07-01 00:00:00
abstract::Stimulation of cutaneous foot afferents has been shown to evoke a facilitation of the tibialis anterior (TA) EMG-activity at a latency of 70-95 ms in the early and middle swing phase of human walking. The present study investigated the underlying mechanism for this facilitation. In those subjects in whom it was possib...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050600
更新日期:1999-01-01 00:00:00
abstract::The effects of short-term, constant practice on the kinematics of a multi-joint pointing movement were studied in the hemiparetic arm of 20 chronic patients with unilateral left cerebro-vascular accident (CVA) and in 10 age- and sex-matched healthy individuals. Practice consisted of a single session of 70 pointing mov...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1568-4
更新日期:2003-10-01 00:00:00
abstract::Hyper-gravity provides a unique environment to study how misperceptions impact control of orientation relative to gravity. Previous studies have found that static and dynamic roll tilts are perceptually overestimated in hyper-gravity. The current investigation quantifies how this influences control of orientation. We ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4215-y
更新日期:2015-05-01 00:00:00
abstract::This study was designed to determine how visual feedback mediates error corrections during reaching. We used visuomotor rotations to dissociate a cursor, representing finger position, from the actual finger location. We then extinguished cursor feedback at different distances from the start location to determine wheth...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1749-x
更新日期:2009-05-01 00:00:00
abstract::The blocking effect of triethyldodecylammoniumbromide (TEA-C12), applied locally to the sciatic nerve, was studied in 28 adult BDF1 mice. Clinical parameters, electrophysiological recordings of muscle action potentials evoked by stimulation at the sciatic notch, and morphological aspects are presented. Our results sho...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00248862
更新日期:1989-01-01 00:00:00
abstract::The distributions of the kainate/DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (KA/ AMPA) receptors GluR1 and calcium-activated neutral protease II (calpain II) in the hippocampus of normal and kainate-lesioned rats were studied by immunocytochemistry. There was a reduction in GluR1 immunoreactivity and a s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF02454147
更新日期:1997-01-01 00:00:00
abstract::In a previous study, we found that haptic guidance from a robotic steering wheel can improve short-term learning of steering of a simulated vehicle, in contrast to several studies of other tasks that had found that the guidance either impairs or does not aid motor learning. In this study, we examined whether haptic gu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-2026-8
更新日期:2010-03-01 00:00:00
abstract::Previous studies have shown that the vestibular short-latency-evoked potential (VsEP) in response to the brief head acceleration stimulus is a compound action potential of neurons innervating the otolith organs. However, due to the lack of direct evidence, it is currently unclear whether the VsEP is primarily generate...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3602-5
更新日期:2013-08-01 00:00:00
abstract::Studies of movement-related cortical potentials (MRCPs) for simple movements have shown a slowly rising negativity (Bereitschaftspotential, or BP) about 2 s prior to movement onset, centered in the bilateral sensorimotor area. However, complex movements may elicit a different temporal and spatial distribution of this ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2314-x
更新日期:2005-06-01 00:00:00
abstract::Conspicuous nerve-cell assemblies, identified as the marginal nuclei described in other sauropsidans, were found all along the spinal cord of turtles. gamma-aminobutyric acid (GABA) and nitric oxide synthase (NOS) activities were colocalized within these neurons, which also reacted positively to reduced nicotinamide a...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050499
更新日期:1998-09-01 00:00:00
abstract::In studies of human eye-head coordinated saccadic gaze shifts, different laboratories have found greatly different magnitudes of head movements for a given amplitude of gaze shift (head movement gain). The present study was conducted to examine why, and to quantify volitional head movements. Fixation/target lights wer...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230391
更新日期:1992-01-01 00:00:00
abstract::We determined whether uncertainty about the location of one's hand in virtual environments limits the efficacy of online control processes. In the Non-aligned and Aligned conditions, the participant's hand was represented by a cursor on a vertical or horizontal display, respectively. In the Natural condition, particip...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2487-9
更新日期:2011-02-01 00:00:00
abstract::Judgments on laterality of hand stimuli are faster and more accurate when dealing with one's own than others' hand, i.e. the self-advantage. This advantage seems to be related to activation of a sensorimotor mechanism while implicitly processing one's own hands, but not during explicit one's own hand recognition. Here...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4210-3
更新日期:2015-04-01 00:00:00
abstract::The total number of granule cells in the dentate gyrus was estimated in 17 male rats, four each aged 30, 120, and 200 days, and five aged 365 days. There is a substantial 35-43% linear increase between 1 month and 1 year. Two parameters of the granular layer are involved in the numerical change. First, total granular ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238626
更新日期:1982-01-01 00:00:00
abstract::Extracellular Ca2+ activity (aCa) changes were measured with Ca2+-sensitive microelectrodes in the cat cerebral cortex during iontophoretic administration of excitatory and inhibitory aminoacids. Glutamate, aspartate and DL homcysteate usually decreased aCa from a baseline of 1.3 mM to as low as 0.1 mM. The amplitude ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237788
更新日期:1980-01-01 00:00:00
abstract::Tone bursts produced bands of selective 2-[14C]-deoxyglucose labelling in the inferior colliculus (IC) of the awake monkey. Low tone frequencies produced labelling in dorsal regions and high tone frequencies produced labelling in ventral regions. The position of the bands coincided with the position of a single unit w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237983
更新日期:1984-01-01 00:00:00