Role of NMDA and non-NMDA receptors in synaptic transmission in rat piriform cortex.

Abstract:

:The pharmacology of synaptic transmission was studied in slices of rat piriform cortex using the selective non-NMDA glutamate receptor antagonist 6.7-dinitroquinoxaline-2,3-dione (DNQX) and the selective NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5). DNQX produced a dose-dependent blockade of synaptic transmission at both lateral olfactory tract and associational system synapses with half-maximal effects at about 2.5 microM. D-AP5 had no significant effects on field potentials recorded in medium containing 2.5 mM Mg++. However in low Mg++ (100-200 microM) medium, D-AP5 did reduce a slow component of postsynaptic responses in both synaptic systems. In Mg(++)-free medium, 20 microM DNQX did not completely block transmission; the remaining response components were blocked by D-AP5. These results suggest that normal synaptic transmission in the two main inputs to the superficial layers of piriform cortex is mediated by non-NMDA receptors but that NMDA receptors can also participate under conditions where the Mg++ block of the NMDA channel is alleviated.

journal_name

Exp Brain Res

authors

Jung MW,Larson J,Lynch G

doi

10.1007/BF00231264

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

451-5

issue

2

eissn

0014-4819

issn

1432-1106

journal_volume

82

pub_type

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