Abstract:
:The pharmacology of synaptic transmission was studied in slices of rat piriform cortex using the selective non-NMDA glutamate receptor antagonist 6.7-dinitroquinoxaline-2,3-dione (DNQX) and the selective NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5). DNQX produced a dose-dependent blockade of synaptic transmission at both lateral olfactory tract and associational system synapses with half-maximal effects at about 2.5 microM. D-AP5 had no significant effects on field potentials recorded in medium containing 2.5 mM Mg++. However in low Mg++ (100-200 microM) medium, D-AP5 did reduce a slow component of postsynaptic responses in both synaptic systems. In Mg(++)-free medium, 20 microM DNQX did not completely block transmission; the remaining response components were blocked by D-AP5. These results suggest that normal synaptic transmission in the two main inputs to the superficial layers of piriform cortex is mediated by non-NMDA receptors but that NMDA receptors can also participate under conditions where the Mg++ block of the NMDA channel is alleviated.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Jung MW,Larson J,Lynch Gdoi
10.1007/BF00231264subject
Has Abstractpub_date
1990-01-01 00:00:00pages
451-5issue
2eissn
0014-4819issn
1432-1106journal_volume
82pub_type
杂志文章abstract::The course and cerebellar termination of the axons of the cells in the central cervical nucleus (CCN) was studied in five cats after injections of wheat germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) into the C1-4 segments involving the CCN. In two cats a hemisection was performed ipsilateral to and above ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00248549
更新日期:1987-01-01 00:00:00
abstract::For the vestibulo-ocular reflex (VOR) to function properly, namely to ensure a stable retinal image under all circumstances, it should be able to take into account varying eye positions in the orbit and varying orientations of the head with respect to the axis about which it is rotating. We tested this capability by q...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238215
更新日期:1986-01-01 00:00:00
abstract::Under free-viewing conditions, the leftward stimulus features are frequently overestimated (pseudoneglect). This asymmetry could reflect the operation of: (a) spatial attention mechanisms in the right hemisphere (RH) or, (b) stimulus-specific activation. To test these propositions, we attempted to induce a stimulus-sp...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0303-8
更新日期:2006-06-01 00:00:00
abstract::Haptic perception is based on the integration of afferent proprioceptive and tactile signals. A further potential source of information during active touch is predicted sensory feedback (PSF) derived from a copy of efferent motor commands that give rise to the exploratory actions. There is substantial evidence that PS...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1996-x
更新日期:2010-01-01 00:00:00
abstract::How are multiple, multi-sensory stimuli combined for use in segmenting spatio-temporal events? For an answer, we measured the effect of various auditory or visual stimuli, in isolation or in combination, on a bistable percept of visual motion ("bouncing" vs. "streaming"). To minimize individual differences, the physic...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0897-0
更新日期:2007-07-01 00:00:00
abstract::This kinematic study aimed to determine whether color is a stimulus property involved in the control of reaching-grasping movements. Subjects reached and grasped a target-object, located either on the right or on the left of the subject's midline. A distractor, placed along the subject's midline, could be randomly pre...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000639
更新日期:2001-03-01 00:00:00
abstract::Eight human subjects were exposed to 2 h of walking on the perimeter of a horizontally rotating disc with the body remaining still in space. After adaptation to this experience subjects were blindfolded and asked to walk straight ahead on firm ground. When doing so all subjects generated curved walking trajectories of...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00230658
更新日期:1995-01-01 00:00:00
abstract::Intracellular recordings from thalamic neurons receiving cerebellar inputs were performed under urethane anesthesia in the rat. A total of 64 neurons were recorded intracellularly with micropipettes filled with 4% biocytin solution (dissolved in 0.5 M K-acetate), and cerebellar-induced EPSPs (CN-EPSPs), the membrane r...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231841
更新日期:1991-01-01 00:00:00
abstract::The saccadic system has been traditionally regarded as two-dimensional (horizontal, vertical) and basically conjugate in the two eyes. However, saccades to disparate targets (e.g., targets in real three-dimensional space that are located in different directions and at different distances) are naturally disconjugate. W...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s002210050529
更新日期:1998-10-01 00:00:00
abstract::Cerebral palsy (CP) is a group of non-progressive developmental movement disorders inducing a strong brain reorganization in primary and secondary motor areas. Nevertheless, few studies have been dedicated to quantify brain pattern changes and correlate them with motor characteristics in CP children. In this context, ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-5149-3
更新日期:2018-02-01 00:00:00
abstract::The spatial separation of the eyes in animals with overlapping visual fields means that parts of a three dimensional object project to slightly disparate retinal points in each eye. This disparity, once interpreted by the brain, is thought to be a sufficient condition for stereoperception. In the present experiment, s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239515
更新日期:1986-01-01 00:00:00
abstract::Transient changes in extracellular potassium concentration ([K+]o) and field potentials were evoked by 4-aminopyridine (4-AP; 50-100 microM) and recorded with ion-selective microelectrodes in CA1b, CA3b and dentate sectors of adult rat hippocampal slices. Long-lasting field potentials recurred at a frequency of approx...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228628
更新日期:1996-04-01 00:00:00
abstract::A task has been developed to investigate the ability of cats to switch the direction of an ongoing target-reaching forelimb movement with the aid of a visual cue. The cats were standing in front of two horizontal tubes (internal diameter 30 mm; shoulder level) with food. The entrances of the tubes were closed with opa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228841
更新日期:1990-01-01 00:00:00
abstract::During the course of an in vivo intracellular labeling study, a chandelier (axo-axonic) cell was completely filled with biocytin in the CA1 region of the hippocampus. Chandelier cells are known to provide GABAergic terminals exclusively to the axon initial segment of pyramidal cells. The lateral extent and laminar dis...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230934
更新日期:1992-01-01 00:00:00
abstract::We have previously reported that electrical stimulation in LC or NRM when tested on the activity of a multireceptive neurone in the spinal cord produced similar inhibitory actions. The present study aimed to define the pathways that mediate this descending inhibitory action in the spinal cord by pharmacological means ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237586
更新日期:1986-01-01 00:00:00
abstract::In cats the stretch responses of deafferented Ia afferent fibers from gastrocnemius muscle spindles were measured. The response properties were derived by correlating the action potentials to random mechanical stimuli applied to the gastrocnemius muscle. The muscle stretch consisted of band-limited, normally distribut...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235615
更新日期:1985-01-01 00:00:00
abstract::Encoding of visual target location in extrapersonal space requires convergence of at least three types of information: retinal signals, information about orbital eye positions, and the position of the head on the body. Since the position of gaze is the sum of the head position and the eye position, inaccuracy of spati...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241543
更新日期:1994-01-01 00:00:00
abstract::Erythropoietin (Epo) has neuroprotective and neurotrophic effects and improves cognitive function in animal models of neurodegenerative and neuropsychiatric illness. In humans, weekly Epo administration over 3 months improves cognitive function in schizophrenia. The neural underpinnings and time-course of this effect ...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s00221-007-1102-1
更新日期:2008-01-01 00:00:00
abstract::The reinforcement learning hypothesis of dopamine function predicts that dopamine acts as a teaching signal by governing synaptic plasticity in the striatum. Induced changes in synaptic strength enable the cortico-striatal network to learn a mapping between situations and actions that lead to a reward. A review of the...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-009-2060-6
更新日期:2010-01-01 00:00:00
abstract::Microinjections of D,L homocysteic acid (DLH, 40 nmoles) made in the lateral PAG of the unanesthetized and paralyzed decerebrate cat evoked distinct patterns of extracranial and hindlimb blood flow. One pattern, evoked from the pretentorial part of the lateral PAG (A3.3-A2.5), consisted of an extracranial vasodilation...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230972
更新日期:1991-01-01 00:00:00
abstract::In order to assess the effects of [K+]o on the passive membrane properties of neostriatal neurons, the cable properties of these cells were determined at two extracellular potassium concentrations (6.25 and 3.0 mM). The effect of tetraethylammonium (TEA) on cable properties was also studied at 6.25 [K+]o. At 6.25 mM [...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00250260
更新日期:1988-01-01 00:00:00
abstract::Sleep disturbances impair cognitive functioning in typically developing populations. Children with attention-deficit/hyperactivity disorder (ADHD), a disorder characterized by impaired inhibitory control and attention, commonly experience sleep disturbances. Whether inhibitory impairments are related to sleep deficits...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-4906-7
更新日期:2017-05-01 00:00:00
abstract::Previous studies have used a secondary probe reaction time (RT) task to assess attentional demands of a primary task. The current study used a startling acoustic stimulus (SAS) in a probe RT paradigm to test the hypothesis that attentional resources would be directly related to limitations in response preparation. Par...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4340-7
更新日期:2015-09-01 00:00:00
abstract::It has previously been shown that unilateral ablation of the whole auditory cortex in the cat disrupts the precedence effect, and also interferes with the ability of the normal animal to discriminate in the Y-maze between a single sound on one side and a double sound consisting of a signal on both left and right sides...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237601
更新日期:1978-02-15 00:00:00
abstract::Motor function difficulties associated with unilateral spastic cerebral palsy (USCP) impact gait inter-limb coordination between the upper and lower extremities. Two motor learning based, upper extremity treatments, Constraint Induced Movement Therapy (CIMT) and Hand Arm Bimanual Therapy (HABIT), have resulted in impr...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05501-6
更新日期:2019-06-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS) using intensities ≤ 2 mA on physical and cognitive outcomes has been extensively investigated. Studies comparing the effects of different intensities of tDCS have yielded mixed results and little is known about how higher intensities (> 2 mA) affect outcomes. This study e...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-019-05721-w
更新日期:2020-02-01 00:00:00
abstract::The visual responses of postarcuate neurons have been studied in alert behaving monkeys (Macaca nemestrina). In particular, the effect of eye position on the location of visual responses in respect to the body has been examined. It was found that a large percentage of bimodal (visual and somatosensory) neurons have vi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239214
更新日期:1983-01-01 00:00:00
abstract::Pontine omnipause neurons (OPNs) have so far been considered as forming a homogeneous group of neurons whose tonic firing stops during the duration of saccades, when the head is immobilized. In cats, they pause for the total duration of gaze shifts, when the head is free to move. In the present study, carried out on a...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050685
更新日期:1999-04-01 00:00:00
abstract::Fetal spinal cord tissue was grafted to the anterior chamber of the eye of adult recipients. Transverse segments from the cervical and high thoracic levels were divided in halves which were grafted directly or further divided into ventral horn and dorsal horn parts before grafting. Survival and intraocular growth was ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237016
更新日期:1985-01-01 00:00:00
abstract::Responses to binocular visual stimulation were compared in cortical area 18 of normal cats and in cats in which one eye was exodeviated by surgery early in postnatal life. In contrast to normal cats where most units (58%) were binocularly activated, relatively few units (10%) in strabismic cats were activated well by ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238169
更新日期:1984-01-01 00:00:00