Abstract:
:Fetal spinal cord tissue was grafted to the anterior chamber of the eye of adult recipients. Transverse segments from the cervical and high thoracic levels were divided in halves which were grafted directly or further divided into ventral horn and dorsal horn parts before grafting. Survival and intraocular growth was monitored through the cornea. Grafts from E14 to E16 grew to final sizes several times the initial size. The final size of E17 grafts was approximately similar to the initial size, while the final size of E18 and E19 grafts was considerably smaller than the size at grafting. All grafts were well vascularized from the host iris. Grafts from younger donors contained several neurons typical of spinal cord including alpha-moto-neuron-type cells. Cells were found in clusters in gray matter areas surrounded by white matter. Extracellular recording revealed many spontaneously active cells. Several had high sustained discharge (10-25 Hz) and large amplitudes. Many cells could be excited by stimulation of the graft surface via activation of local afferents. It is concluded that the capacity of fetal spinal cord tissue to survive grafting to the eye chamber is inversely related to the donor age. Before E17, large grafts retaining several morphological and electrophysiological characteristics of spinal cord are obtained. The intraocular spinal cord graft provides a useful model for studies of spinal cord development and, using co-grafting techniques, a model for spinal cord regeneration and functional connectivity.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Henschen A,Hoffer B,Olson Ldoi
10.1007/BF00237016subject
Has Abstractpub_date
1985-01-01 00:00:00pages
38-47issue
1eissn
0014-4819issn
1432-1106journal_volume
60pub_type
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00608243
更新日期:1990-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238839
更新日期:1981-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00340493
更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1978-04-14 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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