Abstract:
:Parkinson's disease (PD) is a multifactorial disease with a complex etiology that results from genetic risk factors, environmental exposures and most likely a combination of both. Rodent models of parkinsonism aim to reproduce key pathogenic features of the syndrome including movement disorder induced by the progressive loss of dopaminergic neurons in the substantia nigra, accompanied by the formation of alpha-synuclein containing Lewy body inclusions. Despite the creation of many excellent models, both chemically induced and genetically engineered, there is none that accurately demonstrates these features. Recent pathological staging studies in man have also emphasized the significant non-CNS component of PD that has yet to be tackled. Herein, we summarize rodent models of PD and what they offer to the field, and suggest future challenges and opportunities.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Melrose HL,Lincoln SJ,Tyndall GM,Farrer MJdoi
10.1007/s00221-006-0461-3subject
Has Abstractpub_date
2006-08-01 00:00:00pages
196-204issue
2eissn
0014-4819issn
1432-1106journal_volume
173pub_type
杂志文章,评审abstract::The effect of fatigue on finger force perception within a hand during ipsilateral finger force matching was examined. Thirteen subjects were instructed to match a reference force of an instructed finger using the same or different finger within the hand before and after index finger fatigue. Absolute reference force t...
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