Parkinson's disease: a rethink of rodent models.

Abstract:

:Parkinson's disease (PD) is a multifactorial disease with a complex etiology that results from genetic risk factors, environmental exposures and most likely a combination of both. Rodent models of parkinsonism aim to reproduce key pathogenic features of the syndrome including movement disorder induced by the progressive loss of dopaminergic neurons in the substantia nigra, accompanied by the formation of alpha-synuclein containing Lewy body inclusions. Despite the creation of many excellent models, both chemically induced and genetically engineered, there is none that accurately demonstrates these features. Recent pathological staging studies in man have also emphasized the significant non-CNS component of PD that has yet to be tackled. Herein, we summarize rodent models of PD and what they offer to the field, and suggest future challenges and opportunities.

journal_name

Exp Brain Res

authors

Melrose HL,Lincoln SJ,Tyndall GM,Farrer MJ

doi

10.1007/s00221-006-0461-3

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

196-204

issue

2

eissn

0014-4819

issn

1432-1106

journal_volume

173

pub_type

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