Abstract:
:This study examined c-fos protein expression in the brain and spinal cord of rats following permanent occlusion of the middle cerebral artery (MCA) above the rhinal fissure. At 1 h after right-sided MCA occlusion, Fos-like immunoreactivity (Fos-LI) was detected in neurons not only in the ipsilateral cerebral cortex but also in the spinal cord. In the latter, Fos-LI was localized in the nucleus and perikarya of neurons in the grey matter, notably the large motor neurons in the ventral horn. Fos-LI was most intense at 2-4 h, but became undetectable after 48 h in the cerebral cortex and 72 h in the spinal cord. In sham-operated animals, Fos-LI was almost undetectable or virtually absent. It was also not detected in the core territory supplied by the MCA at any time points after arterial occlusion. When the ischaemia-induced neuronal damage in both the cerebral cortex and spinal cord was evaluated by Nissl staining, some neurons appeared atrophic. We conclude that the induction of Fos-LI in neurons of the cerebral cortex and spinal cord is linked respectively to early onset-short stimulation and persistent excitatory or disinhibition phenomenon as a result of focal ischaemic brain injury.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Wu YP,Tan CK,Ling EAdoi
10.1007/pl00005672subject
Has Abstractpub_date
1997-06-01 00:00:00pages
129-36issue
1eissn
0014-4819issn
1432-1106journal_volume
115pub_type
杂志文章abstract::Tactile motion perception is one of the most important functions for realizing a delicate appreciation of the tactile world. To explore the neural dynamics of motion processing in the brain, the motion adaptation phenomenon can be a useful probe. Tactile motion aftereffects (MAE), however, have not been reported in a ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0979-z
更新日期:2007-07-01 00:00:00
abstract::Intracortical inhibition was investigated in normal human volunteers by paired-pulse transcranial magnetic stimulation, using a new, computer-assisted threshold-tracking method. Motor threshold was defined as the stimulus amplitude required to evoke a motor evoked potential of 0.2 mV (peak-to-peak) in abductor pollici...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-001-0988-2
更新日期:2002-03-01 00:00:00
abstract::Intracellular recordings from thalamic neurons receiving cerebellar inputs were performed under urethane anesthesia in the rat. A total of 64 neurons were recorded intracellularly with micropipettes filled with 4% biocytin solution (dissolved in 0.5 M K-acetate), and cerebellar-induced EPSPs (CN-EPSPs), the membrane r...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231841
更新日期:1991-01-01 00:00:00
abstract::The biceps femoris (BF) muscle is divided into three neuromuscular compartments defined by the innervation patterns of the main nerve branches (English and Weeks 1987). The goals of this study were i) to determine how different regions of the biceps femoris muscle are activated in the intact cat during a broad range o...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229406
更新日期:1991-01-01 00:00:00
abstract::When dividing attention between the left and right sides of physical space, most individuals pay slightly more attention to the left side. This phenomenon, known as pseudoneglect, may also occur for the left and right sides of mental representations of stimuli. Representational pseudoneglect has been shown for the rec...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4735-0
更新日期:2016-11-01 00:00:00
abstract::This study investigated the effects of declined accommodation on reading performance in non-native and native languages. Eighteen native Japanese speakers participated: eight presbyopes and ten non-presbyopes. In the experiment, participants were asked to scan, or sequentially read six-word items presented in two-line...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05588-x
更新日期:2019-09-01 00:00:00
abstract::In the cat it is known that the distribution and modulation of the so-called P2 responses are similar, irrespective of whether they are obtained with electrodes implanted in the different skin areas or in the various leg muscles. In man it is known that the specific stimulation of cutaneous afferents from different pa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1366-4
更新日期:2003-04-01 00:00:00
abstract::We examined the influence of acetylcholine (ACh) on the visual response properties of lagged cells in the dorsal lateral geniculate nucleus of anaesthetised cats. By means of electrophysiological techniques, the response of single cells was recorded before, during and after ionophoretic application of ACh. ACh evoked ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227137
更新日期:1993-01-01 00:00:00
abstract::Successful results obtained by training sessions using optokinetic (OK) stimulations in order to rehabilitate patients with balance disorders motivated this study. The purpose of the study was to measure eye movement parameters and body stabilization during OK stimulation before and after the rehabilitation program. T...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00232446
更新日期:1994-01-01 00:00:00
abstract::Single neurons were recorded from the superficial layers of the superior colliculus of immobilized monkeys (Macaca mulatta and Macaca irus). Two main functional types of neurons were found. The neurons of the first type (Type I neurons) responded well to simple stationary and moving stimuli such as spots, bars or slit...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237928
更新日期:1980-01-01 00:00:00
abstract::Linear and angular control of trunk and leg motion during curvilinear navigation was investigated in subjects with cerebellar ataxia and age-matched control subjects. Subjects walked with eyes open around a 1.2-m circle. The relationship of linear to angular motion was quantified by determining the ratios of trunk lin...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3074-z
更新日期:2012-05-01 00:00:00
abstract::Ocular responses to optokinetic stimulation were reexamined in adult albino rats of two different strains. Eye movements were measured in head-restrained animals using the search coil method. In contrast to some previous results, the albino rats showed optokinetic nystagmus, and some of them made responses comparable ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235639
更新日期:1985-01-01 00:00:00
abstract::Extracellularly recorded action potentials from 49 Bötzinger-complex, bulbospinal expiratory neurones were used as triggers to compute 162 spike-triggered averages (STAs) of intracellular potentials recorded from 167 respiratory neurones in the ventral respiratory group (VRG) near the obex in 15 vagotomized, paralysed...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050612
更新日期:1999-01-01 00:00:00
abstract::The goal of this study was to determine the effect of changes in core body temperature on the resting discharge rate and sensitivity of vestibular-nerve afferents. Extracellular recordings were made from vestibular-nerve afferents innervating the semicircular canals in anesthetized C57BL/6 mice maintained at a core bo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-2015-y
更新日期:2010-01-01 00:00:00
abstract::1. The responses are described of cochlear nucleus neurons of anaesthetized cats as a function of time in dependence on intensity and frequency of tonal stimuli. Depending on spectral properties three types are distinguished in the group of spontaneously active units: A type (activation only) AS type (activation and s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238021
更新日期:1975-10-24 00:00:00
abstract::Interactions from both inhibitory and excitatory interneurons are necessary components of cortical processing that contribute to the vast amount of motor actions executed by humans daily. As transcranial magnetic stimulation (TMS) over primary motor cortex is capable of activating corticospinal neurons trans-synaptica...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-020-05875-y
更新日期:2020-08-01 00:00:00
abstract::The firing patterns of alpha and gamma efferent fibres and of group I and group II afferent fibres innervating the gastrocnemius muscle were observed during spontaneous locomotor movements in the thalamic cat. Multi-unit discharges of each kind of fibre were obtained by electronic sorting of the action potentials from...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00340493
更新日期:1986-01-01 00:00:00
abstract::We ask whether a target's velocity is considered when planning a fast interceptive action. Human volunteers hit targets that could move at different velocities from across a tilted screen (the hand starting 40 cm away from the screen). We examined how the direction in which the hand initially moved depended on the tar...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-1832-2
更新日期:2004-07-01 00:00:00
abstract::Dual task paradigms can be used to examine the interactions between cognition and the control of posture and gait. Measuring and interpreting changes in dual task performance is challenging, however, because many factors can influence performance. This study examined the effects of instructed focus and walking task di...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2429-6
更新日期:2010-11-01 00:00:00
abstract::Our aim was to describe the differences in the presence of trigger points (TrPs) in the shoulder muscles and to investigate the presence of mechanical hypersensitivity in patients with unilateral shoulder impingement and healthy controls. Twelve patients with strictly unilateral shoulder impingement and 10 matched con...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2196-4
更新日期:2010-05-01 00:00:00
abstract::Synaptic depression was assessed from intracellular recordings in cortical tissue slices. Evoked postsynaptic potentials exhibited synaptic depression with an exponential or double exponential decrease (time constants: < 1-30 s) in amplitude during repetitive afferent stimulation by short trains of suprathreshold stim...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241364
更新日期:1995-01-01 00:00:00
abstract::The coordination between eye and head movements during a rapid orienting gaze shift has been investigated mainly when subjects made horizontal movements towards visual targets with the eyes starting at the centre of the orbit. Under these conditions, it is difficult to identify the signals driving the two motor system...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/pl00005663
更新日期:1997-05-01 00:00:00
abstract::The fate of monoclonal anti-vasopressin antibodies (VP-MAbs) injected in vivo into the paraventricular nucleus (PVN) of the rat brain was studied by immunocytochemistry. Depending on the post survival time, VP-MAbs contained in an ascites fluid were stained at different levels of the VP neurons: the cytoplasm of the P...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235986
更新日期:1987-01-01 00:00:00
abstract::Local anesthetic may cause neurotoxicity in developing neurons. In this study, we examined the molecular mechanisms of microRNA-210 (miR-210) in regulating bupivacaine-induced dorsal root ganglia (DRG) neurotoxicity in vitro. Young mouse (P30) DRG explants were cultured in vitro and treated with 5 mM bupivacaine to in...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4513-4
更新日期:2016-04-01 00:00:00
abstract::The aim of this study was to evaluate the modulation of muscle activity during locomotor-like movements by different walking speeds in subjects with a motor complete spinal cord injury (SCI) compared to actively--and passively-walking control subjects without neurological deficit. Stepping movements on a treadmill wer...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0509-4
更新日期:2006-10-01 00:00:00
abstract::We describe the simple-spike activity of Purkinje cells (P cells) in the ventral paraflocculus (VPFL) of behaving monkeys in association with movements of the visual scene that evoke short-latency ocular following responses. One group of P cells discharged maximally for downward motion, and the other for motion toward...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228385
更新日期:1993-01-01 00:00:00
abstract::The relations among spatial memory, Stroop-like colour-word subtests, and errors on antisaccade and memory-guided saccadic eye-movement trials for older and younger adults were tested. Two types of errors in the antisaccade task were identified: short latency prosaccade errors that were immediately corrected and longe...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2921-7
更新日期:2012-01-01 00:00:00
abstract::Abundant evidence has revealed that social observation could enhance people's norm-enforcement behaviors to norm violators. However, whether such enhancement is strategically reputation-based without changes on awareness of social norms or it is accompanied with strengthened perception of norm violations remains uncle...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05762-6
更新日期:2020-05-01 00:00:00
abstract::We previously described significant relationships between amplitude variations in slow brain potentials and timed between-press intervals (2.5 s). We suggested that these variations are neural traces of timing mechanisms. To determine which time processing stage is concerned, the current study examines whether these v...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1103-z
更新日期:2002-08-01 00:00:00
abstract::Short interval intracortical inhibition (SICI) is a common paired-pulse TMS technique that is used to measure GABAa-ergic inhibition in the cerebral motor cortex. However, inhibition evaluated with an interstimulus interval (ISI) between the TMS pulses of 2.5 ms has quite different properties from that seen at 1 ms. I...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3369-0
更新日期:2013-03-01 00:00:00