Abstract:
:Synaptic depression was assessed from intracellular recordings in cortical tissue slices. Evoked postsynaptic potentials exhibited synaptic depression with an exponential or double exponential decrease (time constants: < 1-30 s) in amplitude during repetitive afferent stimulation by short trains of suprathreshold stimuli. Depressed synaptic responses with an exponential time course (time constants: 10 s-8 min) during presentation of similar short trains of stimuli every 5 or 10 s. Cortical cells recorded extracellularly in cat visual cortex show similar time constants of response decrement during adaptation to moving stripes. Postsynaptic voltage- or ion-regulated conductances and chloride conductances do not appear to be involved in synaptic depression. Input resistance changes and effects of injection of chloride indicate a lack of GABAA receptor-mediated effects. Hyperpolarizing or depolarizing neurons, and pairing polarization with afferent stimulation, also did not affect synaptic depression. This distinguishes these processes from long-term depression and long-term potentiation. Our results suggest that the most likely mechanisms of synaptic depression and adaptation in cortical cells are presynaptic decrease in transmitter release and/or receptor desensitization. Short-term postsynaptic changes may also occur after synaptic depression.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Finlayson PG,Cynader MSdoi
10.1007/BF00241364subject
Has Abstractpub_date
1995-01-01 00:00:00pages
145-55issue
1eissn
0014-4819issn
1432-1106journal_volume
106pub_type
杂志文章abstract::After injection of 3H dihydrotestosterone, concentration and retention of radioactivity occur in nuclei of certain neurons in the spinal cord and spinal ganglia as well as in dorsal and ventral root cells of chick embryos at day 10, 12, and 18. Cell of the glycogen body show nuclear labeling at day 12, but not at day ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236561
更新日期:1981-01-01 00:00:00
abstract::A wealth of evidence implicates the crossed descending projection from the superior colliculus (SC) in orientation and approach behaviours directed towards novel, non-noxious stimuli. In our preceding paper, we identified a population of nociceptive neurones in the rat SC that have axons that project to the contralate...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231781
更新日期:1996-05-01 00:00:00
abstract::We constructed average histograms from responses evoked by flashing stimuli and noted previously described variations in the shape of the response profile, particularly with respect to sharpness of the peak. To express this variable, we measured the half-rise latency, which is the latency from stimulus onset required ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00242177
更新日期:1995-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241731
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00242013
更新日期:1995-01-01 00:00:00
abstract::Following an almost total chemical lesion of the inferior olive, the inhibitory control of the cerebellar Purkinje cells upon their target neurones, mainly in Deiters nucleus, remains practically unchanged. This result is at variance with some recent findings having important implications in the cerebellar theories of...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236909
更新日期:1981-01-01 00:00:00
abstract::Previous work has highlighted the role of haptic feedback for manual dexterity, in particular for the control of precision grip forces between the index finger and thumb. It is unclear how fine motor skills involving more than just two digits might be affected, especially given that loss of sensation from the hand aff...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05583-2
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241368
更新日期:1996-06-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1183-9
更新日期:2002-10-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247281
更新日期:1987-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00234770
更新日期:1975-03-27 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1231-6
更新日期:2008-03-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237506
更新日期:1981-01-01 00:00:00
abstract::A syntactic and a semantic task were performed by German-speaking healthy subjects and aphasics with lesions in the dominant left hemisphere. In both tasks, pictures of objects were presented that had to be classified by pressing buttons. The classification was into grammatical gender in the syntactic task (masculine ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100794
更新日期:2001-09-01 00:00:00
abstract::Excitation and inhibition of jaw-closing motoneurons (Masseteric and Temporal Motoneurons, Mass. and Temp. Mns) during transient jaw closing, the so-called jaw-closing reflex, and prolonged jaw opening elicited by palatal stimulation were studied. By pressing the anterior palatal surfaces sustained jaw opening was eli...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227075
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00221-012-3142-4
更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00221-018-5358-4
更新日期:2018-11-01 00:00:00
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/pl00005749
更新日期:1997-09-01 00:00:00
abstract::Heparin affin regulatory peptide (HARP), also known as pleiotrophin or heparin-binding growth-associated molecule, is a developmentally regulated extracellular matrix protein that induces cell proliferation and promotes neurite outgrowth in vitro as well as pre- and postsynaptic developmental differentiation in vivo. ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000536
更新日期:2000-12-01 00:00:00
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更新日期:2003-02-01 00:00:00
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journal_title:Experimental brain research
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更新日期:1978-08-15 00:00:00
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journal_title:Experimental brain research
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更新日期:2012-06-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1025-x
更新日期:2007-10-01 00:00:00
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s002210000663
更新日期:2001-04-01 00:00:00
abstract::The purpose of this research was to ascertain whether gravitational cues contribute to localisation ability of mentally represented cutaneous targets. Eight right-handed male subjects were asked to use each hand to point accurately toward four points in the anterior trunk midline solely on the basis of the mental repr...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100723
更新日期:2001-05-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230904
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
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