Effects of neonatal splitting of the optic chiasm on the development of feline visual callosal connections.

Abstract:

:During normal postnatal development, there is an overproduction and subsequent partial elimination of the callosal projections of cortical areas 17 and 18 in the cat. In the present study, we investigated how neonatal splitting of the optic chiasm affects this process. Our results indicate that neonatal splitting of the optic chiasm exaggerates the normally occurring partial elimination of immature callosal projections: it causes a significant reduction in the total number of neurons in the supragranular layers that send an axon through the corpus callosum. It does not, however, cause a significant change in the number of callosally projecting neurons in the infragranular layers. These data suggest that in addition to other factors previously described, the level or spatial distribution of correlated binocular input to visual cortical neurons may influence the stabilization/elimination of immature callosal connections.

journal_name

Exp Brain Res

authors

Boire D,Morris R,Ptito M,Lepore F,Frost DO

doi

10.1007/BF00242013

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

275-86

issue

2

eissn

0014-4819

issn

1432-1106

journal_volume

104

pub_type

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