Abstract：
:Linear and angular control of trunk and leg motion during curvilinear navigation was investigated in subjects with cerebellar ataxia and age-matched control subjects. Subjects walked with eyes open around a 1.2-m circle. The relationship of linear to angular motion was quantified by determining the ratios of trunk linear velocity to trunk angular velocity and foot linear position to foot angular position. Errors in walking radius (the ratio of linear to angular motion) also were quantified continuously during the circular walk. Relative variability of linear and angular measures was compared using coefficients of variation (CoV). Patterns of variability were compared using power spectral analysis for the trunk and auto-covariance analysis for the feet. Errors in radius were significantly increased in patients with cerebellar damage as compared to controls. Cerebellar subjects had significantly larger CoV of feet and trunk in angular, but not linear, motion. Control subjects also showed larger CoV in angular compared to linear motion of the feet and trunk. Angular and linear components of stepping differed in that angular, but not linear, foot placement had a negative correlation from one stride to the next. Thus, walking in a circle was associated with more, and a different type of, variability in angular compared to linear motion. Results are consistent with increased difficulty of, and role of the cerebellum in, control of angular trunk and foot motion for curvilinear locomotion.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Goodworth AD,Paquette C,Jones GM,Block EW,Fletcher WA,Hu B,Horak FBdoi
10.1007/s00221-012-3074-zsubject
Has Abstractpub_date
2012-05-01 00:00:00pages
151-61issue
1eissn
0014-4819issn
1432-1106journal_volume
219pub_type
杂志文章abstract：:Synaptic depression was assessed from intracellular recordings in cortical tissue slices. Evoked postsynaptic potentials exhibited synaptic depression with an exponential or double exponential decrease (time constants: < 1-30 s) in amplitude during repetitive afferent stimulation by short trains of suprathreshold stim...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241364
更新日期：1995-01-01 00:00:00
abstract：:In two monkeys, we measured the initial vergence eye movements elicited by sudden forward motion on a linear sled. Animals faced a tangent screen and experienced the translation while in darkness, fixating a small, centered spot, or viewing a large-field pattern. Forward movements elicited convergent responses that we...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1351-y
更新日期：2003-02-01 00:00:00
abstract：:In order to further our understanding of action-blindsight, four hemianopic patients suffering from visual field loss contralateral to a unilateral occipital lesion were compared to six healthy controls during a double task of verbally reported target detection and saccadic responses toward the target. Three oculomoto...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3803-y
更新日期：2014-03-01 00:00:00
abstract：:In natural environments depth-related information has to be extracted very fast from binocular disparity even if cues are presented shortly. However, few studies used efMRI to study depth perception. We therefore analyzed extension and localization of activation evoked by depth-by-disparity stimuli that were displayed...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1844-z
更新日期：2009-07-01 00:00:00
abstract：:The present experiments were designed to investigate the neuronal mechanisms, at the level of the primary somatosensory cortex, which underlie the observation that somatosensory cortical potentials evoked by air puff stimuli directed at the forearm are decreased, in a nonspecific and widespread manner, during voluntar...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231455
更新日期：1991-01-01 00:00:00
abstract：:Motor sequence learning is a process whereby a series of elementary movements is re-coded into an efficient representation for the entire sequence. Here we show that human subjects learn a visuomotor sequence by spontaneously chunking the elementary movements, while each chunk acts as a single memory unit. The subject...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1548-8
更新日期：2003-09-01 00:00:00
abstract：:The aim of this study was to define the relative contribution of self-generated cutaneous and proprioceptive feedback to haptic shape discrimination by systematically constraining the exploratory strategy. Subjects (n = 23) explored pairs of two-dimensional (2-D) angles (standard angle, 90 degrees; comparison angles, ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0728-8
更新日期：2007-04-01 00:00:00
abstract：:In a previous study, we assessed the synchronous neural interactions (SNI) in a developing neural network in brain cultures on multielectrode arrays (Christopoulos et al. in J Neural Eng 9:046008, 2012). Here, we report on the effects of apolipoprotein E4 (apoE4) on these neural interactions. We carried out six experi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4270-4
更新日期：2015-06-01 00:00:00
abstract：:This investigation represents a first study dealing with the dimorphic differences of the main alpha-containing gamma-aminobutyric acid (GABA(A)) receptors in the brain of two distantly related mammals (hedgehog and rat). The labeling of these receptors in the presence of zolpidem (highly selective benzodiazepine agon...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002219900246
更新日期：2000-02-01 00:00:00
abstract：:Migraine affects the autonomous nervous system and a recent investigation has also proposed a severe disturbance of dynamic cerebral blood flow regulation in the middle cerebral artery during spontaneous blood pressure oscillations. This study investigates whether dynamic cerebral autoregulation is impaired in persons...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-0879-2
更新日期：2007-07-01 00:00:00
abstract：:The effect of body posture on the human soleus H-reflex via electrical stimulation of the tibial nerve at the popliteal fossa was studied. All parameters that may influence the reflex were controlled stringently. H-reflexes were elicited in three different body postures while keeping the level of background muscle act...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5182-x
更新日期：2018-03-01 00:00:00
abstract：:Postural equilibrium is known to be controlled by sensorimotor reflexes and automatic control loops but also depends on high-level body representation in space, probably implicating the right temporoparietal cortex. Indeed, short-term prism adaptation to a 10 degrees rightward visual shift has been shown to reduce pre...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1294-3
更新日期：2003-01-01 00:00:00
abstract：:Movement sequences such as typing or tapping display important interactions among finger movements arising from anticipatory motion (preparing for upcoming events) and coupling (non-independence among fingers). We examined pianists' finger tapping for the influence of cognitive chunking processes and biomechanical cou...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0760-8
更新日期：2007-04-01 00:00:00
abstract：:Few investigations have examined mental workload during motor practice or learning in a context of team dynamics. This study examines the underlying cognitive-motor processes of motor practice by assessing the changes in motor performance and mental workload during practice of reaching movements. Individuals moved a r...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5136-8
更新日期：2018-02-01 00:00:00
abstract：:We investigated the effect of musical expertise on sensitivity to asynchrony for drumming point-light displays, which varied in their physical characteristics (Experiment 1) or in their degree of audiovisual congruency (Experiment 2). In Experiment 1, 21 repetitions of three tempos x three accents x nine audiovisual d...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1817-2
更新日期：2009-09-01 00:00:00
abstract：:Previous studies have found that affective states with high motivational intensity narrow attentional scope, whereas affective states with low motivational intensity broaden attentional scope. This conclusion, however, is based on fragmented evidence based on several separate studies. The present study tests this conc...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4014-x
更新日期：2014-10-01 00:00:00
abstract：:Developmental changes in the human brain coincide with and underlie changes in a wide range of motor and cognitive abilities. Neuroimaging studies have shown that musical training can result in structural and functional plasticity in the brains of musicians, and that this plasticity is greater for those who begin trai...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0619-z
更新日期：2007-01-01 00:00:00
abstract：:Stair walking is a challenging locomotor task, and visual information about the steps is considered critical to safely walk up and down. Despite the importance of such visual inputs, there remains relatively little information on where gaze is directed during stair walking. The present study investigated the role of v...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2520-z
更新日期：2011-03-01 00:00:00
abstract：:Scientific interest has increased the influence of temperature in neurodegenerative and psychiatric disorders, and according to the monoamine hypothesis, depression is a neurochemical disorder arising from hypofunctioning of brain monoamine systems. Here, in vivo flow-oxymetry is applied to verify relationships betwee...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3443-2
更新日期：2013-10-01 00:00:00
abstract：:The purpose of this study is to analyze the coordination patterns of the elevation angles of lower limb segments following the onset of unsupported walking in children and to look for the existence of a planar covariation rule as previously described in adult human locomotion. The kinematic patterns of locomotion were...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210000663
更新日期：2001-04-01 00:00:00
abstract：:The distribution and morphology of developing corpus callosum (CC) axons in rat visual cortex was studied by unilateral application of the in vivo anterograde tracer biotinylated dextran amine (BDA) to the visual or auditory cortex of newborns through adults. Changes in the distribution and morphology of CC axons duri...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000576
更新日期：2001-01-01 00:00:00
abstract：:An aberrant crossed corticotectal pathway can be generated by removal of one visual cortex and the contralateral superior colliculus from newborn rats. This aberrant crossed corticotectal projection arises from the pyramidal neurons located in layer V of the visual cortex and terminates in a spatially orderly manner i...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235562
更新日期：1978-11-15 00:00:00
abstract：:Transcranial direct current stimulation (tDCS) induces cortical excitability changes in animals and humans that can last beyond the duration of stimulation. Preliminary evidence suggests that tDCS may have an analgesic effect; however, the timing of these effects, especially when associated with consecutive sessions o...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3149-x
更新日期：2012-08-01 00:00:00
abstract：:Six cats were reared with surgically produced squint or atropinisation of one eye during the sensitive period of development. Five cats were reared without an ocular interference but in the same environment as the experimental cats. Four of these normally reared cats provided control data for perikaryal size. When the...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235784
更新日期：1982-01-01 00:00:00
abstract：:Second-order vestibular neurons of frogs receive converging monosynaptic excitatory and disynaptic excitatory and inhibitory inputs following electrical pulse stimulation of an individual semicircular canal nerve on the ipsilateral side. Here we revealed, in the in vitro frog brain, disynaptic inhibitory postsynaptic ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000544
更新日期：2000-12-01 00:00:00
abstract：:Neuronal activity was studied in the primary (M1), supplementary (M2), dorsal premotor (PMd), and ventral premotor (PMv) cortex of awake, behaving rhesus monkeys. The animals performed forelimb movements to three targets, each approached by three different types of trajectories. With one trajectory type, the monkey mo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231153
更新日期：1991-01-01 00:00:00
abstract：:We compared pursuit responses to 2D target motion in three separate conditions: predictable, randomised and randomised with timing cues. The target moved on a continuous quadrilateral path in which right-angle direction changes allowed anticipatory eye acceleration and deceleration in orthogonal axes to be assessed. R...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4164-x
更新日期：2015-03-01 00:00:00
abstract：:The spike trains of X and Y retinal ganglion cell axons and neurons in the lateral geniculate nucleus (LGN) of cats were compared to determine if the visual signal could be better discriminated from the maintained activity in the LGN relative to the retina. Curves for relative or receiver operating characteristics (RO...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248364
更新日期：1988-01-01 00:00:00
abstract：:The amygdala has been demonstrated to contribute to pain-related behavior and food preference. Here, the effect of pain on food preference and food-matched visual-cue memory, in the presence or absence of a basolateral amygdala (BLA) lesion, has been evaluated using a novel innovative apparatus and protocol. Forty adu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05961-1
更新日期：2020-10-26 00:00:00
abstract：:Stroke is one of the leading causes of mortality and morbidity in advanced countries of the world. Despite the fact that reactive oxygen and nitrogen species (ROS and RNS) are the by-products of normal metabolic processes and mediate important physiological processes, they can inflict damage to the cell if produced in...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-007-1050-9
更新日期：2007-09-01 00:00:00
