Abstract:
:Stroke is one of the leading causes of mortality and morbidity in advanced countries of the world. Despite the fact that reactive oxygen and nitrogen species (ROS and RNS) are the by-products of normal metabolic processes and mediate important physiological processes, they can inflict damage to the cell if produced in excess due to oxidative stress. In the present review, we focus on the cellular and molecular aspects of ROS and RNS generation and its role in the pathogenesis of stroke produced by hypoxia-reperfusion (H-R) phenomena that elicit oxidative stress. We outline the reasons for the vulnerability of the brain to ischaemic insult, chronic infection and inflammation as well as the natural defence mechanisms against radical mediated injury. We deal with the effect of ROS and RNS on intracellular signaling pathways together with the phenomena of apoptosis, mitochondrial injury and survival associated with these pathways. The intracellular signaling mechanisms influenced by reactive species can have significant effects on the outcome of the condition. Future studies should focus on understanding the molecular mechanisms involved in the action of anti-radicals agents, and their mode of action.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Saeed SA,Shad KF,Saleem T,Javed F,Khan MUdoi
10.1007/s00221-007-1050-9subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1-10issue
1eissn
0014-4819issn
1432-1106journal_volume
182pub_type
杂志文章,评审abstract::Two components of long-term potentiation (LTP) are distinguished with extracellular recording electrodes: a synaptic and an EPSP-Spike (E-S) component. The latter consists of the enhancement produced in the population spike amplitude in excess of that predicted by EPSP potentiation alone. The experiments carried out i...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229331
更新日期:1990-01-01 00:00:00
abstract::We investigated the relationships between cortical arousal and cholinergic facilitation of evoked responses in the auditory cortex. The basal forebrain (BF) was stimulated unilaterally, while cluster recordings were obtained simultaneously from both auditory cortices in urethane-anesthetized rats. The global electroen...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241531
更新日期:1994-01-01 00:00:00
abstract::Earlier studies have shown that eye positions, recorded in subjects scanning a distant visual scene with the head in a stable position, have only two degrees of freedom (Listing's law). Due to cyclovergence, this law is modified in near-vision. Two previous quantitative studies have documented that the sign of the tor...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228754
更新日期:1994-01-01 00:00:00
abstract::While we walk through the environment, we constantly receive inputs from different sensory systems. For us to accomplish a given task, for example to reach a target location, the sensory information has to be integrated to update our knowledge of self-position and self-orientation with respect to the target so that we...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1146-1
更新日期:2002-08-01 00:00:00
abstract::Neurostimulation, e.g., transcranial direct current stimulation (tDCS), shows promise as an effective cognitive intervention. In spite of low spatial resolution, limited penetration, and temporary influence, evidence highlights tDCS-linked cognitive benefits in a range of cognitive domains. The left posterior parietal...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4090-y
更新日期:2014-12-01 00:00:00
abstract::Grasping using two forelimbs in opposition to one another is evolutionary older than the hand with an opposable thumb (Whishaw and Coles in Behav Brain Res 77:135-148, 1996); yet, the mechanisms for bimanual grasps remain unclear. Similar to unimanual grasping, the localization of matching stable grasp points on an ob...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3643-9
更新日期:2013-10-01 00:00:00
abstract::Transparency is perceived when two or more objects or surfaces can be separated by the visual system whilst they are presented in the same region of the visual field at the same time. This segmentation of distinct entities on the basis of overlapping local visual cues poses an interesting challenge for the understandi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3631-0
更新日期:2013-09-01 00:00:00
abstract::The contributions of somatosensory, vestibular, and visual feedback to balance control are well documented, but the influence of auditory information, especially acoustic noise, on balance is less clear. Because somatosensory noise has been shown to reduce postural sway, we hypothesized that noise from the auditory mo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4304-y
更新日期:2015-08-01 00:00:00
abstract::The present study extends our previous findings in challenging the traditional interpretation of irregularities in the velocity profile of pointing movements as corrective submovements performed to improve accuracy of target achievement. The study is driven by a hypothesis that pointing includes at least two subtasks,...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0603-7
更新日期:2007-01-01 00:00:00
abstract::Two superimposed gratings, which differ in orientation and move independently, combine into a coherently moving plaid if the component gratings are similar. The effect on the plaid motion percept of the addition of texture to each grating was investigated. The texture disambiguates the motion of each component grating...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228400
更新日期:1993-01-01 00:00:00
abstract::Vigilance is the ability to sustain attention to information for prolonged periods of time, particularly in environments where critical signals may be rare. Recent research in the domain of mind-wandering has suggested that processes associated with mind-wandering may underpin the typical decline in vigilance task per...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5438-5
更新日期:2019-02-01 00:00:00
abstract::When someone grasps an object, the grasp depends on the intended object manipulation and usually facilitates it. If several object manipulation steps are planned, the first step has been reported to primarily determine the grasp selection. We address whether the grasp can be aligned to the second step, if the second s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-4892-9
更新日期:2017-05-01 00:00:00
abstract::We explored the effects of sensory information upon procedural learning using three versions of the serial reaction-time task (SRTT): a standard task where the position of the stimulus cued the response; a non-standard task where the color of the stimulus was related to the correct response; and a combined task where ...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002210000673
更新日期:2001-04-01 00:00:00
abstract::Many vertebrates generate blinks as a component of saccadic gaze shifts. We investigated the nature of this linkage between saccades and blinking in normal humans. Activation of the orbicularis oculi, the lid closing muscle, EMG occurred with 97% of saccadic gaze shifts larger than 33 degrees. The blinks typically beg...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227203
更新日期:1994-01-01 00:00:00
abstract::The pattern of gamma-efferent innervation of the muscle spindle was investigated in the peroneus tertius muscle of the cat. A number of spindle group Ia afferents were isolated and monitored during tetanic stimulation of isolated gamma-axons. The sample was dominated by efferents producing a static fusimotor effect on...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236812
更新日期:1983-01-01 00:00:00
abstract::The simultaneous presentation of a visual and an auditory stimulus can lead to a decrease in people's ability to perceive or respond to the auditory stimulus. In this study, we investigate the effect that threat has upon this phenomenon, known as the Colavita visual dominance effect. Participants performed two blocks ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1608-1
更新日期:2009-02-01 00:00:00
abstract::A growing number of studies investigated anisotropies in representations of horizontal and vertical spaces. In humans, compelling evidence for such anisotropies exists for representations of multi-floor buildings. In contrast, evidence regarding open spaces is indecisive. Our study aimed at further enhancing the under...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5337-9
更新日期:2018-10-01 00:00:00
abstract::When sight-reading a piece of music the eyes constantly scan the score slightly ahead of music execution. This separation between reading and acting is commonly termed eye-hand span and can be expressed in two ways: as anticipation in notes or in time. Previous research, predominantly in piano players, found skill-dep...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1719-3
更新日期:2009-04-01 00:00:00
abstract::A method was developed to record sterotactically from the cat Superior Olivary Complex (SOC) using glass micropipettes. Sound stimulation was given through a closed system that permitted independent variation of interaural time (delta time) and intensity (delta int) differences. The most common binaural units found (n...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238032
更新日期:1983-01-01 00:00:00
abstract::During goal-directed arm movements, the eyes, head, and arm are coordinated to look at and reach the target. We examined whether the expectancy of visual information about the target modifies Anticipatory Postural Adjustments (APAs). Ten standing subjects had to (1) move the eyes, head and arm, so as to reach, with bo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-4898-3
更新日期:2017-05-01 00:00:00
abstract::The method of microneurography was used to record activity in trigeminal cutaneous and mucosal mechanoreceptive afferents during natural orofacial behaviors such as speech gestures, chewing, licking and swallowing. Multi-unit activity and impulses in single nerve fibers were recorded from the infraorbital nerve. It ap...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00248519
更新日期:1988-01-01 00:00:00
abstract::We investigated the effect of different spatial and temporal parameters on the saccadic reaction times (SRTs) of the antisaccades and on the frequency and the SRTs of erratic prosaccades in five adult human subjects. The subjects were instructed to aim their saccades to the side opposite to where a visual go-stimulus ...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/pl00005749
更新日期:1997-09-01 00:00:00
abstract::Given the number of muscles and joints of the arm, more ways are available to produce an identical hand movement when pointing to a target than are strictly necessary. How the nervous system manages these abundant degrees of freedom was the focus of this study of pointing to targets of low and high indices of difficul...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1357-5
更新日期:2003-04-01 00:00:00
abstract::In anaesthetized cats (chloralose-urethan) the effects of brief tetanic electrical stimulation (50 to 100 ms) of the mesencephalic central gray matter and reticular formation on the inspiratory on-switch were studied during the expiratory (E) phase on the gross and unitary activities of phrenic, laryngeal inspiratory ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237270
更新日期:1984-01-01 00:00:00
abstract::Unilateral isometric muscle contractions increase motor-evoked potentials (MEPs) produced by transcranial magnetic stimulation not only in the contracting muscle but also in the resting contralateral homologous muscle. Corticospinal excitability in the M1 contralateral to the contracting muscle changes depending on th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2397-x
更新日期:2010-09-01 00:00:00
abstract::Stimulus-response compatibility (SRC) effects are classified depending on the way that the elements of the stimulus and response sets interact, influencing both the speed and accuracy of the motor response. This is particularly important for social stimuli, such as hands. However, the stimuli used in most SRC studies ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4283-z
更新日期:2015-07-01 00:00:00
abstract::The biceps femoris (BF) muscle is divided into three neuromuscular compartments defined by the innervation patterns of the main nerve branches (English and Weeks 1987). The goals of this study were i) to determine how different regions of the biceps femoris muscle are activated in the intact cat during a broad range o...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229406
更新日期:1991-01-01 00:00:00
abstract::Coarticulation indicates a dependence of a movement segment on a preceding segment (carry-over coarticulation) or on the segment that follows (anticipatory coarticulation). Here we study coarticulation in multidegrees of freedom human arm movements. We asked participants to transport a cylinder from a starting positio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4327-4
更新日期:2015-09-01 00:00:00
abstract::Ideal grasping movements should maintain an appropriate probability of success, while controlling movement-related costs, in the presence of varying visual (and motor) uncertainty. It is often assumed that the probability of errors is managed by adjusting a margin for error in hand opening (e.g., opening the hand wide...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05489-z
更新日期:2019-04-01 00:00:00
abstract::The McGurk effect, which denotes the influence of visual information on audiovisual speech perception, is less frequently observed in individuals with autism spectrum disorder (ASD) compared to those without it; the reason for this remains unclear. Several studies have suggested that facial configuration context might...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5188-4
更新日期:2018-04-01 00:00:00