Abstract:
:Groups of pregnant rats were injected with two successive daily doses of 3H-thymidine from gestational day 12 and 13 (E12+13) until the day before parturition (E21+22) in order to label in their embryos the proliferating precursors of neurons. At 60 days of age the proportion of neurons generated (or no longer labelled) on specific embryonic days was determined quantitatively in six vertical strips of the inferior colliculus. It was established that the neurons of the inferior colliculus are produced between days E14 and the perinatal period in an orderly sequence: the earliest generated cells are situated rostrally, laterally and ventrally in the principal nucleus, the latest generated cells are situated caudally, medially and dorsally in the pericentral nucleus. This cytogenetic gradient suggested that the cells are produced dorsally in the caudal recess of the embryonic aqueduct and are deployed in an "outside-in" pattern. This study has brought to a conclusion our datings of neuron production in the central auditory pathway of the rat. The results revealed that in those structures in which a cytogenetic gradient could be recognized, the orientation of this gradient and the regional tonotopic order (demonstrated mostly in species other than the rat) tended to be aligned. Moreover, with the exception of the medial trapezoid nucleus and the dorsal nucleus of the lateral lemniscus (which receive contralateral input from the cochlear nuclei), sites with early-produced neurons correlated with units responding preferentially to high frequency tones and vice versa. This suggested that the orderly production of neurons within different components of the auditory system is a factor in their subsequent topographic organization. A comparison of the temporal order of neuron production in different components of the auditory pathway suggested that the establishment of orderly topographic relations between some of the structures (e.g., the medial geniculate body and the primary auditory cortex) takes place before this spatial relationship could be specified as a cochleotopic order.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Altman J,Bayer SAdoi
10.1007/BF00237506subject
Has Abstractpub_date
1981-01-01 00:00:00pages
411-23issue
3-4eissn
0014-4819issn
1432-1106journal_volume
42pub_type
杂志文章abstract::The developing lateral geniculate complex was excised from fetal albino rats at 18 days of gestation and implanted into the occipital cortex of host animals at 5 days of postnatal age. Groups of host animals were sacrificed at 10, 20 and 30 days following this procedure. The transplant tissue of selected animals was s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235864
更新日期:1985-01-01 00:00:00
abstract::The vestibular nuclei and the interstitial nucleus of Cajal (INC) have been regarded as key elements of the velocity-to-position integrator for vertical eye movements. This paper reports a class of type II vestibular neurons that receives input from the INC and carries vertical eye movement signals that appear to repr...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1750-8
更新日期:2004-04-01 00:00:00
abstract::Many neurons in the deeper layers of the superior colliculus (SC) respond to multiple sensory inputs--visual, auditory, and somatic--as well as provide signals essential for saccadic eye movements to targets in different modalities. When the eyes and pinnae are in primary position, the neural map of auditory space is ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231709
更新日期:1995-01-01 00:00:00
abstract::This study examined perception-action learning in younger adults in their 20s compared to older adults in their 70s and 80s. The goal was to provide, for the first time, quantitative estimates of perceptuo-motor learning rates for each age group and to reveal how these learning rates change between these age groups. W...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3349-4
更新日期:2013-03-01 00:00:00
abstract::The present report describes a bidirectional mechanical stimulation technique of cristae ampullares in the cat. Bimodal field potentials are seen in the vestibular nerve and nucleus after an excitatory stimulus. This technique should allow an in vivo and selective study of the vestibular receptors in mammals. ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237804
更新日期:1980-01-01 00:00:00
abstract::Many previous studies have demonstrated the existence of neurons with tremor-frequency activity ("tremor cells") in the thalamus of Parkinson's disease (PD) patients and these neurons are presumed to play a role in the pathogenesis of tremor. Since a major input to motor thalamus (Voa and Vop) is from the internal seg...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/pl00005606
更新日期:1997-03-01 00:00:00
abstract::Single unit recording from trained rhesus monkeys demonstrate that the activity of the prelunate cortex is enhanced when a visual stimulus becomes a target of saccadic eye movement. As a rule, the enhancement is spatially selective: it does not occur if the animal makes an eye movement away from, rather than towards t...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237333
更新日期:1981-01-01 00:00:00
abstract::Effects of sensory deprivation upon ability of a vibrissa to activate a functional column in the barrel field of somatosensory cortex were examined with 2 deoxyglucose (2DG) autoradiography in the rat. After six weeks of whisker plucking started at birth, and one week of recovery, the cortical column activated by the ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230950
更新日期:1992-01-01 00:00:00
abstract::The fear of falling can be manipulated by introducing a postural threat (e.g., an elevated support surface) during stance and gait. Under these conditions, balance parameters are altered in both young and elderly individuals. This study aimed to dissociate the physical and psychological aspects of the threat and show ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-4902-y
更新日期:2017-05-01 00:00:00
abstract::Several studies have shown that rapid manual aiming movements from one to the other wing of Müller-Lyer illusion figures are biased in a manner consistent with their influence on perceptual judgments. Two experiments examined the role of extent and position information in Müller-Lyer figures in biasing pointing moveme...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2156-y
更新日期:2005-05-01 00:00:00
abstract::Successfully picking up and handling objects requires taking into account their physical properties (e.g., material) and position relative to the body. Such features are often inferred by sight, but it remains unclear to what extent observers vary their actions depending on the perceived properties. To investigate thi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4631-7
更新日期:2016-08-01 00:00:00
abstract::The two long toe flexor muscles in the cat, flexor digitorum longus (FDL) and flexor hallucis longus (FHL), have essentially identical mechanical actions, yet are used very differently during locomotion (O'Donovan et al. 1982). We attempted to identify the origin of the synaptic drive responsible for this functional d...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235825
更新日期:1984-01-01 00:00:00
abstract::Previous studies have demonstrated changes in motor memories with the passage of time on the order of hours. We sought to further this work by determining the influence that time on the order of seconds has on motor learning by changing the duration between successive reaches (inter-reach-interval (IRI)). Human subjec...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0062-6
更新日期:2005-11-01 00:00:00
abstract::Differential pulse voltammetry was performed in rats chronically implanted with carbon fiber electrodes in the caudate (n.Cd) and raphe dorsalis (n.RD) nuclei. The electrochemical signal obtained at the +300 mV potential (peak 3) in animals implanted for more than one week (long term chronic conditions, greater than 7...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00340496
更新日期:1986-01-01 00:00:00
abstract::The evoked expression of the immediate early gene-encoded proteins c-Fos and Krox-24 was used to study activation of hindbrain neurons as a function of the development of cyclophosphamide (CP) cystitis in behaving rats. CP-injected animals received a single dose of 100 mg/kg i.p. under transient volatile anesthesia an...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227263
更新日期:1996-03-01 00:00:00
abstract::In 15 musicians, cortical DC-potentials were recorded from the scalp before and during the execution of bimanual motor sequences. Subjects (Ss) either tapped with their two index fingers in synchrony (quavers against quavers; "2 against 2") or they tapped quavers against triplets ("2 against 3"). Either the right or t...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229320
更新日期:1990-01-01 00:00:00
abstract::We studied the effects of morphine injected either systemically or into the dorsal periaqueductal gray (DPAG) or nucleus accumbens (NA) using conventional and ethological analyses of behavior of rats submitted to the elevated plus-maze test with transparent walls. Intraperitoneal morphine (0.1 mg/kg and 0.3 mg/kg) inc...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050896
更新日期:1999-11-01 00:00:00
abstract::Anxious individuals have been shown to interpret others' emotional states negatively. Since most studies have used facial expressions as emotional cues, we examined whether trait anxiety affects the recognition of emotion in a dynamic face and voice that were presented in synchrony. The face and voice cues conveyed ei...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2668-1
更新日期:2011-09-01 00:00:00
abstract::We recognize objects even when they are partially degraded by visual noise. Using monkeys performing a sequential delayed match-to-sample task, we studied the relation between the amount of visual noise (5, 10, 15, 20 or 25%) degrading the eight black and white stimuli used here, and the accuracy and speed with which ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2230-0
更新日期:2005-05-01 00:00:00
abstract::This study addressed some of the controversial issues surrounding the anticonvulsant effect of phenytoin, and the predictive validity of the guinea-pig kindling model for the screening of anticonvulsant drugs. Following an intraperitoneal injection of either 50 or 75 mg/kg phenytoin, we analysed plasma concentrations ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100852
更新日期:2001-10-01 00:00:00
abstract::The task of sliding a nut from a rod has been used to study manual slowing in old age (Smith et al. in Neurology 53:1458-1461, 1999; Neurobiol Aging 26:883-890, 2005). In this experiment, we sought to determine if the age-related slowing in this task occurs with losses of motor precision, as indicated by the forces ex...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-2030-z
更新日期:2010-03-01 00:00:00
abstract::In the present study the neurotoxic effects of a low dosage (0.5 mg/kg per day) of methylmercury (MeHg) on the developing nervous system were investigated. Pregnant rats were treated with MeHg from day 7 of pregnancy to day 7 of lactation. Locomotor activity (locomotion, rearing, and motility) and spatial learning abi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050237
更新日期:1997-12-01 00:00:00
abstract::Heparin affin regulatory peptide (HARP), also known as pleiotrophin or heparin-binding growth-associated molecule, is a developmentally regulated extracellular matrix protein that induces cell proliferation and promotes neurite outgrowth in vitro as well as pre- and postsynaptic developmental differentiation in vivo. ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000536
更新日期:2000-12-01 00:00:00
abstract::It has previously been shown that unilateral ablation of the whole auditory cortex in the cat disrupts the precedence effect, and also interferes with the ability of the normal animal to discriminate in the Y-maze between a single sound on one side and a double sound consisting of a signal on both left and right sides...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237601
更新日期:1978-02-15 00:00:00
abstract::We investigated motor control perspectives of coordinating maintenance of posture and application of grip force when holding an object and being perturbed. Ten subjects stood on the force platform holding an instrumented object in their dominant hand and were exposed to an external perturbation applied to their should...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4717-2
更新日期:2016-11-01 00:00:00
abstract::Integration of tactile afferent signals with motor commands is crucial for the performance of purposeful movements such as during manipulation of an object in the hand. To study the somatotopic organization of sensorimotor integration we applied electrical peripheral conditioning stimuli to a digit located near (homot...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050005
更新日期:2000-01-01 00:00:00
abstract::The purpose of this study was to investigate the time-course of corticospinal excitability during reaction time (RT), and compare the excitability when a precue provided information regarding both the direction and extent of the upcoming movement ('Full' condition), specified the direction of the upcoming movement onl...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1772-2
更新日期:2004-05-01 00:00:00
abstract::Transcranial magnetic stimulation (TMS) causes the corticospinal system to become refractory to subsequent stimuli for up to 200 ms. We examined the phenomenon of paired pulse inhibition with TMS under conditions of rest, ongoing voluntary activation (isometric force generation), and at variable delays following activ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228638
更新日期:1996-04-01 00:00:00
abstract::The microtubule associated tau protein becomes hyperphosphorylated in Alzheimer's disease (AD). While hyperphosphorylation promotes neurodegeneration, the cause and consequences of this abnormal modification are poorly understood. As impaired energy metabolism is an important hallmark of AD progression, we tested whet...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5341-0
更新日期:2018-11-01 00:00:00
abstract::During voluntary movement, muscle spindles of both the agonist and antagonist muscles potentially can supply information about position of the limb. Muscle vibration is known to increase muscle spindle discharge and cause systematic distortions of limb position sense in humans. The following two experiments attempted ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF02423506
更新日期:1990-01-01 00:00:00