Abstract:
:We studied the effects of morphine injected either systemically or into the dorsal periaqueductal gray (DPAG) or nucleus accumbens (NA) using conventional and ethological analyses of behavior of rats submitted to the elevated plus-maze test with transparent walls. Intraperitoneal morphine (0.1 mg/kg and 0.3 mg/kg) increased both standard and ethological measures, expressing general exploratory activity such as total arm entries, end-exploration, scanning, head-dipping, and rearing. Morphine 10 (7.6 microg/microl) and 30 nmol (23 microg/microl) injected into nucleus accumbens produced similar effects, which were blocked by i.p. naltrexone (2.0 mg/kg), an opioid antagonist with good affinity for mu-opioid receptors. Morphine injected into the DPAG produced either antiaversive (10 nmol) or aversive effects (30 nmol), which respectively reduced and increased entries and time spent in the open arms and behaviors associated with risk assessment (peeping out, stretched attend postures, and flat back approach). The proaversive effects were inhibited by i.p. norbinaltorphimine (2.0 mg/kg), a selective inhibitor for kappa-opioid receptors. These findings support the contention that at least some of the motivational effects of morphine may be due to activation of opioid mechanisms in nucleus accumbens, and DPAG has neural substrates for antiaversive and aversive effects of morphine. Moreover, on the basis of previous and present data obtained in this laboratory, it is suggested that stimulation of mu-opioid receptors inhibits and stimulation of kappa-receptors activates the neural substrate of aversion in the DPAG. On the other hand, the increase in exploratory behavior due to interaction of morphine with mu-opioid receptors in the nucleus accumbens may be due to the stimulation of the interface between neural substrates of motivation and motor output in this structure.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Anseloni VC,Coimbra NC,Morato S,Brandão MLdoi
10.1007/s002210050896keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
260-8issue
2eissn
0014-4819issn
1432-1106pii
91290260.221journal_volume
129pub_type
杂志文章abstract::We have previously reported that electrical stimulation in LC or NRM when tested on the activity of a multireceptive neurone in the spinal cord produced similar inhibitory actions. The present study aimed to define the pathways that mediate this descending inhibitory action in the spinal cord by pharmacological means ...
journal_title:Experimental brain research
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doi:10.1007/BF00237586
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abstract::It has been argued that through a process of internal 'simulation', we automatically map observed actions directly onto our motor system to facilitate imitation. Instead, here we show that observed actions influence the kinematic parameters of manual responses in a dynamic, context-dependent fashion. Participants obse...
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2225-3
更新日期:2010-05-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229320
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pub_type: 杂志文章
doi:10.1007/s00221-007-0978-0
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doi:10.1007/s00221-015-4493-4
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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