Abstract:
:The evoked expression of the immediate early gene-encoded proteins c-Fos and Krox-24 was used to study activation of hindbrain neurons as a function of the development of cyclophosphamide (CP) cystitis in behaving rats. CP-injected animals received a single dose of 100 mg/kg i.p. under transient volatile anesthesia and survived for 1 to 4 h in order to cover the whole postinjection period during which the disease develops. CP-injected groups included: (1) animals with minor simple chorionic edema, an early characteristic of inflammation (1 h postinjection); (2) animals with well-developed simple chorionic edema (2 h postinjection); (3) animals with mild inflammation (chorionic edema accompanied by epithelial cleavage; 3 h postinjection); and (4) animals with complete inflammation (4 h postinjection). In addition to onset of chorionic edema, the earliest postinjection period also included the general aspects of the nervous reaction consecutive to the injection process (handling, transient volatile anesthesia and postanesthesia awakening, abdominal pinprick, CP-blood circulating effects). Controls included both noninjected animals and saline-injected animals surviving for the same times as CP-injected ones. Quantitative results come from c-Fos expression. It has been shown that: (1) saline injection is a significant stimulus for only nucleus O and central gray pars alpha and nucleus medialis of the dorsal vagal complex; (2) all structures driven by CP injection (nucleus O and central gray pars alpha, locus coeruleus, Barrington's nucleus and parabrachial area mostly in its ventral and lateral subdivisions, dorsal vagal complex, ventrocaudal portion of lateral bulbar reticular formation) responded vigorously shortly after injection, but only two (dorsal vagal complex, ventrocaudal portion of lateral bulbar reticular formation) showed increased or renewed activity when cystitis completely developed, i.e., when noxious visceral inputs reached highest levels. Regarding the sequential activation of these structures in relation to postinjection time, evidence is given that: (1) a large variety of hindbrain structures are differentially involved in either the general reaction consecutive to the injection process or to various degrees of cystitis; (2) these structures extend from the brain-spinal cord to the pons-mesencephalon transitional junction levels; (3) the two structures most powerfully driven by visceronociceptive inputs are also the most caudal ones, being located at the brain-spinal cord junction level; and (4) the dorsal vagal complex could be the main hindbrain visceral pain center, with three particular subdivisions, the nucleus medialis, nucleus commissuralis, and ventralmost part of area postrema, being involved.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Bon K,Lantéri-Minet M,de Pommery J,Michiels JF,Menétrey Ddoi
10.1007/BF00227263subject
Has Abstractpub_date
1996-03-01 00:00:00pages
404-16issue
3eissn
0014-4819issn
1432-1106journal_volume
108pub_type
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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doi:10.1007/s00221-014-3868-2
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238380
更新日期:1981-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00231791
更新日期:1996-05-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4039-1
更新日期:2014-11-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00248275
更新日期:1989-01-01 00:00:00
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doi:10.1007/s00221-005-2343-5
更新日期:2005-10-01 00:00:00
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00228128
更新日期:1990-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s002210050361
更新日期:1998-04-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4493-4
更新日期:2016-03-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236735
更新日期:1980-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-001-0908-5
更新日期:2001-12-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00