Dissecting two distinct interneuronal networks in M1 with transcranial magnetic stimulation.

Abstract:

:Interactions from both inhibitory and excitatory interneurons are necessary components of cortical processing that contribute to the vast amount of motor actions executed by humans daily. As transcranial magnetic stimulation (TMS) over primary motor cortex is capable of activating corticospinal neurons trans-synaptically, studies over the past 30 years have provided how subtle changes in stimulation parameters (i.e., current direction, pulse width, and paired-pulse) can elucidate evidence for two distinct neuronal networks that can be probed with this technique. This article provides a brief review of some fundamental studies demonstrating how these networks have separable excitatory inputs to corticospinal neurons. Furthermore, the findings of recent investigations will be discussed in detail, illustrating how each network's sensitivity to different brain states (i.e., rest, movement preparation, and motor learning) is dissociable. Understanding the physiological characteristics of each network can help to explain why interindividual responses to TMS exist, while also providing insights into the role of these networks in various human motor behaviors.

journal_name

Exp Brain Res

authors

Spampinato D

doi

10.1007/s00221-020-05875-y

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

1693-1700

issue

7-8

eissn

0014-4819

issn

1432-1106

pii

10.1007/s00221-020-05875-y

journal_volume

238

pub_type

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