Abstract：
:Gabapentin's main clinical use is in the treatment of neuropathic pain where its binding to neuronal alpha-2/delta subunits of voltage-gated calcium channels (VGCCs) is critical to its mechanism of action. Over the past 10 years, there have been several reports of gabapentin also having anti-nausea and anti-emetic effects in conditions including postoperative nausea and vomiting (PONV), chemotherapy-induced nausea and vomiting (CINV), and hyperemesis gravidarum (HG). In this report, a MEDLINE electronic search was performed, and relevant citations were reviewed and classified by level of evidence; a grade of recommendation was then assigned for gabapentin's use for each studied indication. Out of 33 clinical trials reviewed, 12 assessed nausea and/or vomiting (N/V) associated with gabapentin therapy as primary outcome measures. These 12 studies provided a Grade A recommendation for gabapentin use in treating PONV, a Grade B recommendation for use in treating CINV, and a Grade C recommendation for use in treating HG. Further research is needed to confirm these initial promising results, which implicate the alpha-2/delta VGCC subunit as a novel therapeutic target in the treatment of several N/V-associated clinical conditions.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Guttuso T Jrdoi
10.1007/s00221-014-3905-1subject
Has Abstractpub_date
2014-08-01 00:00:00pages
2535-9issue
8eissn
0014-4819issn
1432-1106journal_volume
232pub_type
杂志文章,评审abstract：:Sudden limb displacement evokes a complex sequence of compensatory muscle activity. Following the short-latency reflex and preceding voluntary reactions is an epoch termed the medium-latency reflex (MLR) that could reflect spinal processing of group II muscle afferents. One way to test this possibility is oral ingesti...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5162-6
更新日期：2018-03-01 00:00:00
abstract：:Inhibition of return (IOR) is thought to reflect a bias against returning attention to previously attended locations. According to this view, IOR should occur only if attention is withdrawn from the target location prior to target appearance. In the present study, endogenous attention and exogenous cueing were manipul...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-004-1963-5
更新日期：2004-12-01 00:00:00
abstract：:The mechanisms underlying stress-induced hyperalgesia (SIH) remain poorly understood. Recent findings have provided strong evidence indicating that SIH could be related, at least in part, to alterations in spinal cord GABA activity. In the present study, we first investigated how acute restraint stress impacted pain r...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4027-5
更新日期：2014-11-01 00:00:00
abstract：:Within-arm somatotopy was identified in multiple motor areas of six normal human subjects who performed a visuomotor tracking task during positron emission tomography (PET) measurement of relative cerebral blood flow (relCBF). A randomly moving target, presented on a computer monitor, was continuously followed with th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229666
更新日期：1993-01-01 00:00:00
abstract：:The goal of the present investigation was to determine the time-course by which the motor system might resolve the context-dependent effects of a visual illusion [i.e., the Müller-Lyer (ML) figure]. Specifically, we asked participants to scale their grip aperture (GA) to the perceived size of an object embedded within...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1988-9
更新日期：2004-10-01 00:00:00
abstract：:Observation of hand movements has been repeatedly demonstrated to increase the excitability of the motor cortical representation of the hand. Little attention, however, has been devoted to its effect on somatosensory processing. Movement execution is well known to decrease somatosensory cortical excitability, a phenom...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2448-3
更新日期：2011-01-01 00:00:00
abstract：:The afternystagmus that occurs in the dark after gaze fixation during optokinetic stimulation is directed in the opposite direction relative to the previous optokinetic stimulus. The mechanism responsible for such afternystagmus after suppression of optokinetic nystagmus (ASOKN) is unclear. Several hypotheses have bee...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-014-3971-4
更新日期：2014-09-01 00:00:00
abstract：:Transient receptor potential receptors (TRP) on primary afferent neurons respond to noxious and/or thermal stimuli. TRPV1 receptors can be activated by noxious heat, acid, capsaicin and resiniferatoxin, leading to burning pain or itch mediated by discharges in C polymodal and Adelta mechano-heat nociceptors and in cen...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-009-1760-2
更新日期：2009-06-01 00:00:00
abstract：:The muscle activation patterns in anterior and posterior leg muscles were investigated with two types of perturbations to standing balance. Subjects stood with each foot on adjacent force platforms and performed arm flexion movements to shoulder height. Nine subjects performed ten repetitions unilaterally and bilatera...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1732-x
更新日期：2004-04-01 00:00:00
abstract：:Transient changes in extracellular potassium concentration ([K+]o) and field potentials were evoked by 4-aminopyridine (4-AP; 50-100 microM) and recorded with ion-selective microelectrodes in CA1b, CA3b and dentate sectors of adult rat hippocampal slices. Long-lasting field potentials recurred at a frequency of approx...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228628
更新日期：1996-04-01 00:00:00
abstract：:Previous data have indicated that, if guinea pigs are deprived of all visual information during a crucial period early in development (26-30 days after birth), the map of auditory space in the superior colliculus (SC) is completely disrupted. In the experiments reported here, multi-unit auditory receptive fields were ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241121
更新日期：1995-01-01 00:00:00
abstract：:The influence of a secondary task on speeded responses, and its effect on the outcome of more complex tasks has been studied in detail. However, the consequence of task interference on specific movement parameters other than speed and accuracy has been largely ignored. The current study examines how performing a secon...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2112-y
更新日期：2010-04-01 00:00:00
abstract：:We examined the characteristic features of galanin (GAL)-containing nerve afferents in the intermediolateral nucleus (IML) of the rat lumbosacral spinal cord (L6, S1), i.e., spinal parasympathetic nucleus, by immunocytochemistry at both light and electron microscopic levels. Firstly, the types of synapses formed by GA...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229624
更新日期：1996-06-01 00:00:00
abstract：:This study aimed to examine the effect of explicit cuing on reactive stepping with the paretic limb during slip-like perturbations in stroke survivors and to identify differences in postural stability and fall-risk while stepping with either limb. Eleven chronic hemiparetic stroke survivors received slip-like stance p...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4367-9
更新日期：2015-11-01 00:00:00
abstract：:Tone bursts produced bands of selective 2-[14C]-deoxyglucose labelling in the inferior colliculus (IC) of the awake monkey. Low tone frequencies produced labelling in dorsal regions and high tone frequencies produced labelling in ventral regions. The position of the bands coincided with the position of a single unit w...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237983
更新日期：1984-01-01 00:00:00
abstract：:We previously demonstrated that velocity and movement time for the initial segment for a two-stroke movement are scaled in relation to the difficulty of the second segment. The interdependent kinematic changes were interpreted as evidence that movement planning/organization processes consider the movement parameters o...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000450
更新日期：2000-09-01 00:00:00
abstract：:1.) Eye movements were recorded in four Java monkeys (M. fascicularis) after unilateral microinjections (1 microliter, concentration 1 micrograms/microliter) of the GABA antagonist, bicuculline, and the GABA agonist, muscimol, into oculomotor related regions of the vestibular nuclei. Eye movements were investigated in...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228958
更新日期：1991-01-01 00:00:00
abstract：:The present study investigated the function of the brain activity underlying the visual mismatch negativity (vMMN) event-related potential (ERP) component. Snowflake patterns (complex stimuli) were presented as deviants and oblique bar patterns (simple stimuli) as standards, and vice versa in a passive oddball paradig...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05494-2
更新日期：2019-05-01 00:00:00
abstract：:Perception of our own bodies is based on integration of visual and tactile inputs, notably by neurons in the brain's parietal lobes. Here we report a behavioural consequence of this integration process. Simply viewing the arm can speed up reactions to an invisible tactile stimulus on the arm. We observed this visual e...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1651-x
更新日期：2004-01-01 00:00:00
abstract：:The ventral part of the third visual cortical complex, the ventral posterior area (VP) or V3v, is located between the ventral half of visual areas V2 and V4. Because of its location and the physiological properties of its neurons, VP has been considered to be involved in the ventral stream visual areas. The ventral st...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1698-8
更新日期：2004-03-01 00:00:00
abstract：:It is known that non-clinical subjects with high levels of schizotypal personality traits (High-S), as well as schizophrenic patients, have difficulties to judge how a scene would appear (so-called Appearance questions) from a point of view other than their own after having performed a disembodied perspective taking (...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3991-0
更新日期：2014-10-01 00:00:00
abstract：:We investigated the accuracy with which, in the absence of vision, one can reach again a 2D target location that had been previously identified by a guided movement. A robotic arm guided the participant's hand to a target (locating motion) and away from it (homing motion). Then, the participant pointed freely toward t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1833-1
更新日期：2004-07-01 00:00:00
abstract：:Learning in perceptual tasks is typically highly specific to the trained stimulus parameters. However, can learning be specific to a stimulus parameter that is perceptually indistinguishable from another? We assessed this question using a perceived sound location task in which the perceived sound location was created ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3863-7
更新日期：2014-06-01 00:00:00
abstract：:The effects of repetitive transcranial stimulation (rTMS) on brain activity remain unknown. In healthy subjects, we studied the effects of rTMS on the duration of the cortical silent period (SP). Repetitive stimuli were delivered with a Cadwell High Speed Magnetic Stimulator and a figure-of-eight coil placed over the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050661
更新日期：1999-03-01 00:00:00
abstract：:We explored the action of digits during static prehension tasks involving one hand or two hands of one or two persons. Three hypotheses were tested: to prevent slippage of the object, grip force and safety margin (SM) would be largest in bimanual conditions, particularly involving two persons; the distribution of tang...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1662-8
更新日期：2009-03-01 00:00:00
abstract：:Automatic postural responses of leg muscles to the sudden displacement of standing support were investigated under four different conditions of information given to subjects in advance. Results from three groups of subjects were compared: 6 normal subjects, 10 patients with cerebellar disease, and 9 patients with Park...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231777
更新日期：1991-01-01 00:00:00
abstract：:The visual responses of postarcuate neurons have been studied in alert behaving monkeys (Macaca nemestrina). In particular, the effect of eye position on the location of visual responses in respect to the body has been examined. It was found that a large percentage of bimodal (visual and somatosensory) neurons have vi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239214
更新日期：1983-01-01 00:00:00
abstract：:The habenulo-interpeduncular system of the rat constitutes an interesting model to address quantitatively problems related to synaptogenesis and to the interactions between neuronal populations after selective alteration of these elements during development. In the present study this has been achieved by experimentall...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227241
更新日期：1992-01-01 00:00:00
abstract：:Trace eyeblink conditioning was investigated in 31 patients with focal cerebellar lesions and 19 age-matched controls. Twelve patients presented with lesions including the territory of the superior cerebellar artery (SCA). In 19 patients lesions were restricted to the territory of the posterior inferior cerebellar art...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0171-2
更新日期：2006-03-01 00:00:00
abstract：:Humans are known to show anticipatory adjustments in the grip force prior to a self-generated or predictable action or perturbation applied to a hand-held object. We investigated whether humans can also adjust covariation of individual finger forces (multi-finger synergies) prior to self-triggered perturbations. To ad...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0583-7
更新日期：2006-11-01 00:00:00
