Abstract:
:Sequential intraocular grafting of defined areas from fetal rat brain to adult host rats was used to explore the possibility that such double grafts would become interconnected. Norepinephrine- containing neurons of the locus coeruleus were grafted together with either parietal cerebral cortex, hippocampus, or the caudate nucleus. Dopamine-containing neurons of the substantia nigra were transplanted together with either parietal cerebral cortex or the caudate nucleus. The brainstem grafts showed good survival and development in oculo, using both histochemical and electrophysiological criteria. Locus coeruleus neurons were found to innervate cerebral cortex, hippocampus, and the caudate nucleus. Substantia nigra neurons invaded cerebral cortex abundantly, with a terminal distribution typical of cortical DA terminals in situ. The innervation of the caudate nucleus from substantia nigra transplants was variable, but areas of dense confluent terminals were observed. We conclude that sequential brain grafting in oculo permits generation of isolated yet defined catecholaminergic projections, which are suitable for electrophysiological, pharmacological, and histochemical studies.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Olson L,Seiger A,Hoffer B,Taylor Ddoi
10.1007/BF00236784subject
Has Abstractpub_date
1979-03-09 00:00:00pages
47-67issue
1eissn
0014-4819issn
1432-1106journal_volume
35pub_type
杂志文章abstract::Extracellular recordings were obtained from inferior olivary neurones of the rat. The responses of fifty neurones evoked by electrical stimulation of a branch of the trigeminal nerve were recorded. Maxillary nerve stimulation was most effective. The response was characterized by an early discharge (single spike and wa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238283
更新日期:1976-09-24 00:00:00
abstract::Nociceptive suppression of tonic voluntary electromyographic (EMG) activity in human hand muscles (cutaneous silent period, CSP) is in its functional organization consistent with a spinal protective reflex. Motoneuronal excitability and its modulation may also be investigated by conditioned motor evoked potentials (ME...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1372-2
更新日期:2008-07-01 00:00:00
abstract::Depending on individual lesion location and extent, reorganization of the human motor system has been observed with a high interindividual variability. In addition, variability of forces exerted, of motor effort, and of movement strategies complicates the interpretation of functional imaging studies. We hypothesize th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-001-0981-9
更新日期:2002-03-01 00:00:00
abstract::We examined opioid binding in fractions with disconnected nerve endings (secretosomes) which were prepared from porcine neurohypophyses by centrifugation in a discontinuous Percoll gradient. Specific (= displaceable) binding was observed with 3H-etorphine and with 3H-diprenorphine, two ligands with low selectivity for...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00271856
更新日期:1988-01-01 00:00:00
abstract::Our objective was to determine if caudal ventral respiratory group (VRG) expiratory (E) neurons that drive abdominal expiratory motoneurons in the lumbar cord respond to intercostal and lumbar nerve afferent stimulation. Results showed that 92% of medullary E-neurons that were antidromically activated from the upper l...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230702
更新日期:1989-01-01 00:00:00
abstract::Projections from the posterior thalamic regions to the striatum were studied in the cat by the anterograde tracing method after injecting wheat germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) into the caudalmost regions of the lateroposterior thalamic nucleus (caudal LP), suprageniculate nucleus (Sg) and ma...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235934
更新日期:1985-01-01 00:00:00
abstract::In the present work, we characterize electrophysiologically a commissural subcortical pathway which is related to binocular interactions in the nucleus of the optic tract (NOT) of the opossum. The main role played by the circuit comprising this pathway seems to be in relaying information coming from the ipsilateral ey...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227519
更新日期:1994-01-01 00:00:00
abstract::According to the size principle for motoneurons one would expect that an excitatory stimulus given to a motoneuronal pool should evoke small excitatory postsynaptic potentials (EPSPs) in large and large EPSPs in small motoneurons of the pool. In this study this expectation was tested for the motoneuron pool of the fir...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229117
更新日期:1994-01-01 00:00:00
abstract::In a series of experiments in which the known projections of the septal complex to the hippocampal formation have been transected, we have used both anterograde and retrograde tracing techniques in an attempt to demonstrate a ventral septo-hippocampal pathway. In cases where transections of the fimbria, dorsal fornix ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235290
更新日期:1984-01-01 00:00:00
abstract::The reinforcement learning hypothesis of dopamine function predicts that dopamine acts as a teaching signal by governing synaptic plasticity in the striatum. Induced changes in synaptic strength enable the cortico-striatal network to learn a mapping between situations and actions that lead to a reward. A review of the...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-009-2060-6
更新日期:2010-01-01 00:00:00
abstract::"Quiet standing" is standing without intended movement. To the naked eye, a person "quiet standing" on a rigid surface of support is stationary. In the laboratory quiet standing is indexed by behavior (at the millimeter scale) of the center of pressure (COP), the point location of the vertical ground reaction force ve...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3696-9
更新日期:2013-12-01 00:00:00
abstract::A number of perceptual and neurophysiological studies have investigated the effects of delivering unilateral versus bilateral tactile sensory stimulation. While a number of studies indicate that perceptual discrimination degrades with opposite-hand stimulation, there have been no reports that examined the digit specif...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4045-3
更新日期:2014-11-01 00:00:00
abstract::It has recently been suggested that time perception and motor timing are influenced by the presence of biological movements and animacy in the visual scene. Here, we investigated the interactions among timing, speed and animacy in two experiments. In Experiment 1, observers had to press a button in synchrony with the ...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-012-3338-7
更新日期:2013-02-01 00:00:00
abstract::Saccadic accuracy, measured as the ratio of the size of a saccade to the size of the target step that elicits it, i.e., saccade gain, can be altered by jumping the target surreptitiously during the targeting saccade. The gain change produced by this paradigm does not generalize or transfer to saccades of all sizes. In...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002219900220
更新日期:2000-01-01 00:00:00
abstract::The effects of electrical stimulation of the cerebral cortex on the monosynaptic jaw closing and the disynaptic jaw opening reflexes were studied in cats anaesthetized with chloralose. The time course of the reflex effects was recorded. Similar rhythmic sequences of facilitation and inhibition were observed in both re...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237546
更新日期:1980-01-01 00:00:00
abstract::We examined the effect of the smoothness of motion on vection strength. The smoothness of stimulus motion was modulated by varying the number of frames comprising the movement. In this study, a horizontal grating translated through 360° of phase in 1 s divided into steps of 3, 4, 6, 12, 20, 30, or 60 frames. We hypoth...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-5122-1
更新日期:2018-01-01 00:00:00
abstract::Anxious individuals have been shown to interpret others' emotional states negatively. Since most studies have used facial expressions as emotional cues, we examined whether trait anxiety affects the recognition of emotion in a dynamic face and voice that were presented in synchrony. The face and voice cues conveyed ei...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2668-1
更新日期:2011-09-01 00:00:00
abstract::The blood-brain barrier (BBB) arises from epithelial-like tight junctions that virtually cement adjoining capillary endothelium together in the brain microvasculature. Several experimental manipulations have been shown able to increase the permeability of brain capillaries, by altering endothelial cell membrane integr...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/pl00005725
更新日期:1997-07-01 00:00:00
abstract::Preshaping the digits and orienting the hand when reaching to grasp a distal target is proposed to be optimal when guided by vision. A reach-to-grasp movement to an object in one's own mouth is a natural and commonly used movement, but there has been no previous description of how it is performed. The movement require...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3164-y
更新日期:2012-08-01 00:00:00
abstract::Since normal human subjects can perform smooth-pursuit eye movements only in the presence of a moving target, the occurrence of these eye movements represents an ideal behavioural probe to monitor the successful processing of visual motion. It has been shown previously that subjects can execute smooth-pursuit eye move...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000459
更新日期:2000-08-01 00:00:00
abstract::Previously we described physiological properties of pontine reticulo-spinal neurons which generate bursts and decaying tonic discharges related to eye movements and neck muscle activity during ipsiversive gaze shifts (Grantyn and Berthoz 1987). Two of these "eye-neck reticulo-spinal neurons" (EN-RSN) were labeled by i...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00243310
更新日期:1987-01-01 00:00:00
abstract::Three patients with cerebellar limb ataxia and three age-matched controls performed arm-pointing movements towards a visual stimulus during an experimental procedure using a double-step paradigm in a three-dimensional space. Four types of trajectories were defined: P1, single-step pointing movement towards the visual ...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s002210050361
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:Restoration of somatosensory deficits in humans requires a clear understanding of the neural representations of percepts. To characterize the cortical response to naturalistic somatosensation, we examined field potentials in the primary somatosensory cortex of humans. METHODS:Four patients with intractable e...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05495-1
更新日期:2019-05-01 00:00:00
abstract::(1) The responses of CA1 pyramidal cells to short glutamate pulses (10-50 ms) delivered at sensitive spots in the apical dendrites have been analysed by intracellular recording. (2) The glutamate pulses elicited stable depolarizing responses in a dose- and frequency-dependent manner. (3) When a single action potential...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228178
更新日期:1992-01-01 00:00:00
abstract::Humans use a specific steering synergy, where the eyes and head lead rotation to the new direction, when executing a turn or change in direction. Increasing evidence suggests that eye movement is critical for turning control and that when the eyes are constrained, or participants have difficulties making eye movements...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3466-8
更新日期:2013-05-01 00:00:00
abstract::Encoding of visual target location in extrapersonal space requires convergence of at least three types of information: retinal signals, information about orbital eye positions, and the position of the head on the body. Since the position of gaze is the sum of the head position and the eye position, inaccuracy of spati...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241543
更新日期:1994-01-01 00:00:00
abstract::Stimulation of cutaneous foot afferents has been shown to evoke a facilitation of the tibialis anterior (TA) EMG-activity at a latency of 70-95 ms in the early and middle swing phase of human walking. The present study investigated the underlying mechanism for this facilitation. In those subjects in whom it was possib...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050600
更新日期:1999-01-01 00:00:00
abstract::Conspicuous nerve-cell assemblies, identified as the marginal nuclei described in other sauropsidans, were found all along the spinal cord of turtles. gamma-aminobutyric acid (GABA) and nitric oxide synthase (NOS) activities were colocalized within these neurons, which also reacted positively to reduced nicotinamide a...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050499
更新日期:1998-09-01 00:00:00
abstract::Our goal was to study potential substrates for cortical modulation of vestibular reflexes in the cat. In initial experiments, injections of wheat-germ-agglutinate-horseradish-peroxidase into Deiters' nucleus and the rostral descending nucleus revealed bilateral colonies of retrogradely filled neurons in cortical areas...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050651
更新日期:1999-03-01 00:00:00
abstract::Ganglioside and DNA levels were estimated in the striatum of rats 10 days and 6 weeks after lesioning by intrastriatal injection of kainic acid. There was a moderate, 21-24% decrease of the ganglioside concentration per unit protein on the side of the lesion, which can be ascribed to the loss of the intrinsic striatal...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238752
更新日期:1981-01-01 00:00:00